id,collection,Type de document,DOI,PMID,URL,Titre,Auteur(s),Titre de la manifestation scientifique,Organisateur(s) de la manifestation scientifique,Ville,Pays,Date de début de la manifestation scientifique,Titre de la revue,Numéro,Pagination,Éditeur,Date de publication,ISSN,Mot(s)-clé(s) en anglais,Discipline(s) HAL,Résumé en anglais,Langue,Article revu par les pairs,Audience,Vulgarisation,Projet Européen,Collection
"93322028-8824-4396-b1a5-c30adca35475","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)||Communication dans un congrès avec actes","10.1016/j.pdpdt.2017.01.042",,,"A new flexible and homogeneous device for photodynamic treatment of actinic keratosis","Mordon, Serge||Thecua, E.||Tylcz, J.-B.||Vicentini, C.||Mortier, L.||Szeimies, R.-M.","IPA",,"NANCY","France","2016-10-24",,,,,"2017-03",,,"Sciences du Vivant [q-bio]||Sciences du Vivant [q-bio]/Cancer",,"Anglais","Oui","Internationale","Non",,
"9c91dcb1-1e4b-4d50-ba61-af29461d0318","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)","10.1016/j.revmed.2016.10.386","28268124","http://hdl.handle.net/20.500.12210/39493","Usefulness of nuclear medicine in Erdheim-Chester disease: A Lille experience","Adens, A||Landy, P||Terriou, Louis||Baillet, Clio||Beron, Amandine||Lambert, Marc||Launay, David||Huglo, Damien",,,,,,,,,,"2017-04-01",,,"Sciences du Vivant [q-bio]","INTRODUCTION: Erdheim-Chester disease is a rare form of non-langerhans histiocytosis and its etiology is still not well established. The aims of the study were to assess the value of the bone scintigraphy and the 18F-FDG PET/CT for the diagnostic and for the latter in the therapeutic evaluation. METHODS: We retrospectively reviewed 49 patients suspected of Erdheim-Chester disease between 2004 and 2016. Bone scintigraphy was compared with histopathology and PET-CT to conventional morphological examinations and bone scintigraphy. For  therapeutic evaluation, thresholds similar to PERCIST 1.0 were used. RESULTS: Forty-nine bone scintigraphy were evaluated with a sensitivity of 100%,  a specificity 97%, a positive predictive value 90% and a negative predictive value of 100%. Eight patients had at least an initial PET-CT. The sensitivity compared to conventional morphological examinations differed from the location but was excellent for orbital, bone and vascular involvements. Specificity was comparable between the different examinations. Six patients treated with interferon® and three with vemurafenib® were followed by PET-CT. PET-CT, in agreement to clinicobiological data, identified 4 partial responses and one complete response with interferon® et two partial responses and one complete response with vemurafenib®. CONCLUSION: Our retrospective study suggests that bone scintigraphy and 18F-FDG PET/CT could be useful in the initial assessment of Erdheim-Chester disease but also for the latter in the therapeutic evaluation.","Anglais",,"Internationale","Non",,"Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189"
"b851bc58-7eb9-4dd2-ab9b-40a35201200c","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)","10.1016/j.jhep.2021.05.041","34129887","http://hdl.handle.net/20.500.12210/40907","Loss of hepatocyte identity following aberrant YAP activation: a key mechanism in alcoholic hepatitis","Bou Saleh, Mohamed||Louvet, Alexandre||Ntandja-Wandji, Line Carolle||Boleslawski, Emmanuel||Gnemmi, Viviane||Lassailly, Guillaume||Truant, Stéphanie||Maggiotto, François||Ningarhari, Massih||Artru, Florent||Anglo, Emilie||Sancho-Bru, Pau||Corlu, Anne||Argemi, Josepmaria||Dubois-Chevalier, Julie||Dharancy, Sébastien||Eeckhoute, Jérôme||Bataller, Ramon||Mathurin, Philippe||Dubuquoy, Laurent",,,,,,,,,"Elsevier","2021-06-12",,"Alcoholic hepatitis||Hepatocyte||Hippo/YAP||Regeneration||Transdifferentiation","Sciences cognitives","Background & AimsAlcoholic hepatitis (AH) is a life-threatening disease with limited therapeutic options, because understanding of the molecular drivers leading to death are not well understood. This study evaluates the Hippo/Yes-associated protein (YAP) pathway which has been shown to play a role in liver regeneration.MethodThe Hippo/YAP pathway was dissected in explants of patients transplanted for AH or alcoholic cirrhosis and in control livers, using RNA-Seq, real-time PCR, Western blot, immunohistochemistry (IHC) and transcriptome analysis after laser microdissection. We transfected primary human hepatocytes with constitutively active YAP (YAPS127A) and treated HepaRG cells and primary hepatocytes isolated from AH livers with a YAP inhibitor. We also used mouse models of ethanol exposure (Lieber de Carli) and liver regeneration (CCl4) after hepatocyte transduction of YAPS127A.ResultsIn AH samples RNA-Seq analysis and IHC of total liver and microdissected hepatocytes revealed marked down-regulation of Hippo shown by lower MST1 kinase and abnormal activation of YAP in hepatocytes. Overactivation of YAP in hepatocytes in vitro and in vivo led to biliary differentiation and loss of key biological functions such as regeneration capacity. Conversely, treatment of abnormal hepatocytes from AH patients with a YAP inhibitor restored the mature hepatocyte phenotype. In ethanol-fed mice, YAP activation using YAPS127A resulted in a loss of hepatocyte differentiation. Hepatocyte proliferation was hampered using YAPS127A after CCl4 intoxication.ConclusionAberrant activation of YAP plays an important role in hepatocyte transdifferentiation in AH, through a loss of hepatocyte identity and impaired regeneration. Thus, targeting YAP is a promising strategy for the treatment of patients with AH.Lay summaryAlcoholic hepatitis (AH) is characterized by inflammation and a life-threatening alteration of liver regeneration by mechanisms that have not been identified. We show that AH livers are characterized by profound deregulation of the Hippo/YAP pathway with uncontrolled activation of the transcription co-factor YAP in hepatocytes. YAP activation in hepatocytes leads to their transdifferentiation towards a biliary phenotype associated with inflammation as well as a regeneration defect. YAP inhibition reverts this hepatocyte defect and appears to be an original therapeutic strategy of regenerative treatment for AH.","Anglais","Oui","Internationale","Non",,"Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189"
"3984a791-672e-427e-808f-5ca02ef5fb41","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)||Communication dans un congrès avec actes",,,,"Interstitial photodynamic therapy for glioblastoma: interest of MRI monitoring to predict iPDT effects.","Toussaint, Magali||Auger, Florent||Pinel, Sophie||Durieux, Nicolas||Thomassin, Magalie||Thomas, Eloise||Moussaron, Albert||Meng, Dominique||Plénat, François||Amouroux, Marine||Tylcz, Jean-Baptiste||Galbrun, Ernest||Arnoux, Philippe||Frochot, Céline||Tillement, Olivier||Lux, François||Barberi-Heyob, Muriel","13e Colloque Nano-hybrides","ILM, Lyon 1","Porquerolles","France","2016-05-09",,,,,,,,"Sciences du Vivant [q-bio]/Cancer",,"Anglais","Oui","Internationale","Non",,
"303a408f-badf-41ec-8b99-1970ebef775e","20.500.12210/13","Compte-rendu et recension critique d'ouvrage||Autre communication scientifique (congrès sans actes - poster - séminaire...)","10.1016/j.jceh.2022.06.013","36647412","http://hdl.handle.net/20.500.12210/110202","Liver Transplantation in Alcohol-related Liver Disease and Alcohol-related Hepatitis.","Ntandja Wandji, Line-Carolle||Ningarhari, Massih||Lassailly, Guillaume||Dharancy, Sebastien||Boleslawski, Emmanuel||Mathurin, Philippe||Louvet, Alexandre",,,,,,"Journal of Clinical and Experimental Hepatology","13","127-138",,"2023-01-18","0973-6883","alcohol||alcohol-related liver disease||alcohol-related hepatitis||liver transplantation||survival","Sciences du Vivant [q-bio]","Alcohol-related liver disease (ARLD) remains one of the leading causes of chronic liver disease and the prevalence of alcohol-related cirrhosis is still increasing worldwide. Thus, ARLD is one of the leading indications for liver transplantation (LT) worldwide especially after the arrival of direct-acting antivirals for chronic hepatitis C infection. Despite the risk of alcohol relapse, the outcomes of LT for ARLD are as good as for other indications such as hepatocellular carcinoma (HCC), with 1-, 5-, and 10- year survival rates of 85%, 74%, and 59%, respectively. Despite these good results, certain questions concerning LT for ARLD remain unanswered, in particular because of persistent organ shortages. As a result, too many transplantation centers continue to require 6 months of abstinence from alcohol for patients with ARLD before LT to reduce the risk of alcohol relapse even though compelling data show the poor prognostic value of this criterion. A recent pilot study even observed a lower alcohol relapse rate in patients receiving LT after less than 6 months of abstinence as long as addictological follow-up is reinforced. Thus, the question should not be whether LT should be offered to patients with ARLD but how to select patients who will benefit from this treatment.","Anglais",,,"Non",,"Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189"
"efecd16d-d027-4339-98a0-a8618a1d599c","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)||Communication dans un congrès avec actes","10.1016/j.pdpdt.2017.01.145",,,"Treatment of a vulvar Paget disease by photodynamic therapy with a new light emitting fabric based device","Vicentini, C.||Carpentier, O.||Tylcz, J.-B.||Mortier, L.||Betrouni, N.||Mordon, Serge","IPA",,"NANCY","France","2016-10-24",,,,,"2017-03",,,"Sciences du Vivant [q-bio]||Sciences du Vivant [q-bio]/Cancer",,"Anglais","Oui","Internationale","Non",,
"827e95ed-5ded-4e64-b43c-21574f5ec730","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)||Communication dans un congrès avec actes",,,"http://hdl.handle.net/20.500.12210/108733","Evaluation of a New Anti-Galectin 9 Immunotherapy Strategy in Pancreatic Cancers","Quilbe, Alexandre||Mustapha, Rami||Renaud, S||Duchêne, Belinda||de Schutter, Clémentine||Herlin, G||Moralès, Olivier||van Seuningen, Isabelle||Jonckheere, Nicolas||Delhem, Nadira","11èmes journées scientifiques du Cancéropole Nord Ouest",,"Deauville","France","2018",,,,,,,,"Sciences du Vivant [q-bio]",,"Anglais","Oui","Internationale","Non",,"Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189"
"f5b4e9ea-a3e9-4a3c-ab11-02d511141afb","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)||Communication dans un congrès avec actes","10.1016/j.pdpdt.2017.01.048",,,"Set-up of the first pilot study on intraopertive 5-ALA PDT: INDYGO trial","Mordon, Serge||Vermandel, M.||Quidet, M.||Lecomte, Fabienne||Lerhun, E.||Betrouni, N.||Reyns, N.||Dupont, Clément","IPA",,"NANCY","France","2016-10-24",,,,,"2017-03",,,"Sciences du Vivant [q-bio]||Sciences du Vivant [q-bio]/Cancer","University Lille, INSERM, CHU Lille, U1189 – ONCO-THAI – Image Assisted Laser Therapy for Oncology, Lille, France Nowadays, Glioblastoma Multiform (GBM) remains an incurable brain tumour despite of recent advances in the standard of care. Patients harboring newly diagnosed GBM, de novo GBM, undergo to surgery for maximal tumour resection followed by radiation therapy and concomitant and adjuvant chemotherapy (Temozolomide). This protocol has raised the overall survival to 14.5 months. Promising results have been documented concerning 5-ALA interstitial photodynamic therapies. However, interstitial PDT has always been delivered to treat recurrent or non-operable tumours. Because of heterogeneous population of patients with different care protocols in the context of their relapsing disease or the absence of controlled clinical trial, efficacy of 5-ALA PDT is not still evidenced and thus not included in the standard protocol. In order to prove the 5-PDT efficacy on patients harboring de novo GBM, our group has developed a specific medical device to deliver PDT intraoperatively in the surgical cavity. The main idea is to benefit from the course of 5-ALA Fluores-cence Guided Resection (FGR) to achieve an illumination with the suitable wavelength (635 nm). Treatment of the infiltrating cells by a PDT effect is expected in the first millimeters of the surgical cavity. In such manner, intraoperative PDT is a simple add-on to the standard protocol that is more ethically acceptable and more efficient to assess PDT efficacy. Ten patients will be enrolled. Each patient will undergo standard treatment protocol including PDT early after surgery. 25 J/cm 2 will be delivered at 5 mm of the surgical cavity borders. A fractionation scheme will be applied: 5 fractions of 5 J/cm 2 each with off-period of 2 min between each fraction. A first early post-operative MRI will be acquired on the intraoperative MRI of our department. Then, MRI will be acquired quarterly to monitor the treatment response. The primary endpoint is the feasibility of intraoperative PDT, estimated by the proportion of patients who undergone intraoper-ative PDT without unacceptable toxicity. The expected objective is 70%, 7 of 10 patients that we plan to include. Secondary endpoints are progression-free survival (PFS), overall survival, and evaluation at 3 months, 6 months and 12 months of radiation treatment response and patients' quality of life. Finally, after the feasibility and the absence of adverse effects, our protocol will be experienced through a controlled multicenter clinical trial (Phase II) which will focus on dose escalation (light and 5-ALA) and new biomarkers findings. This multicenter clinical trial will be setup and performed with the support of the European network Synaps (http://www. synaps-project.eu).","Anglais","Oui","Internationale","Non",,
"2aace00d-f61d-4e6c-9c03-faa9c3cd43d6","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)",,,"http://hdl.handle.net/20.500.12210/108732","Evaluation in vitro et in vivo d'une Nouvelle Stratégie d’Immunothérapie ciblant la Galectine-9 dans un modèle de cancer pancréatique.","Quilbe, Alexandre||Mustapha, Rami||Renaud, S||Duchêne, Belinda||de Schutter, Clémentine||Baydoun, Marta||Kumar, A||Moralès, Olivier||van Seuningen, Isabelle||Jonckheere, Nicolas||Delhem, Nadira","12èmes journées scientifiques du Cancéropôle Nord-Ouest",,"Deauville","France","2019",,,,,,,,"Sciences du Vivant [q-bio]",,"Anglais","Oui","Internationale","Non",,"Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189"
"efb299aa-977f-46ff-8959-c3d671e9be5c","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)||Communication dans un congrès avec actes",,,,"Preliminary clinical study to evaluate an interactive system to segment organs at risk in thoracic oncology on CT","Dolz, Jose||Kirisli, H||Fechter, T||Karnitzki, S||Nestle, U||Vermandel, M||Massoptier, L","Radiotherapy and Oncology",,"Turin","Italie","2016-04-29",,,,,"2016-04",,,"Informatique [cs]/Vision par ordinateur et reconnaissance de formes [cs.CV]||Informatique [cs]/Imagerie médicale||Informatique [cs]/Traitement des images [eess.IV]","Purpose: Radiotherapy aims at delivering the highest possible dose to the tumor while minimizing the irradiation of surrounding healthy tissue, and especially to the organs at risk (OARs). Therefore, accurate delineation of 15 OARs is required for radiation treatment planning (RTP). In thoracic oncology, delineation of some OARs remains manual, making the task time consuming and prone to inter observer variability. Various (semi-) automatic approaches have been proposed to segment OARs on CT but the task still remains challenging. Here, a system to interactively segment OARs in thoracic oncology on CT images is presented and its clinical acceptability evaluated. 20 Methods: The proposed framework has been implemented using MITK platform. User interaction lies in the easy definition of few manual seeds for the OARs and background using a 'paintbrush' tool, which can be interactively added in any view (axial, sagittal or coronal), and is subsequently propagated within the whole volume. Once the user is content with the seeds placement, the system automatically performs the segmentation. If the outcome is not satisfying, the user can modify the seeds, which involves adding and/or removing existing seeds, and perform 25 again the automatic segmentation. Number of tries has been limited to five in the current study. If after the five modifications the segmentation result is not sufficient to be usable in the RTP, the user shall reject it; otherwise, he shall accept it. A hybrid approach based on our previous work [1, 2] which combines watershed transformation and graph cuts [3] is used for the segmentation task. Results: The system was evaluated on multivendor CT datasets of 10 patients presenting from early stage to 30 locally advanced NSCLC or pulmonary metastases. OARs taken into consideration in this study were: heart, lungs, oesophagus, proximal bronchus tree, spinal canal and trachea. Interactive contours were generated by a physician using the proposed system. Delineation of the OARs obtained with the presented system was approved to be usable for RTP in more than 90% of the cases, excluding the oesophagus, which segmentation was never approved (Fig 1). On the accepted reported cases, more than 90% of the interactive contours reached a Dice 35 Similarity Coefficient higher than 0.7 with respect to manual segmentations (Fig 2). Therefore, our interactive delineation approach allows users to generate contours of sufficient quality to be used in RTP up to three times faster than manually. Conclusions: An interactive, accurate and easy-to-use computer-assisted system for OARs segmentation in tho-racic oncology was presented and clinically evaluated. The introduction of the proposed approach in clinical 40 routine might offer a valuable new option to radiation therapists (RTTs) in performing OARs delineation task. Consequently, further experiments have been conducted on larger databases and with the participation of additional RTTs to investigate its potential use in daily clinical practice [4].","Anglais","Oui","Internationale","Non",,
"829b461b-9f77-4a81-9312-04e65c023523","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)||Communication dans un congrès avec actes",,,,"Folate-targeted photosensitizer for the treatment of peritoneal metastasis of epithelial ovarian cancer by photodynamic therapy","Frochot, Céline||Colombeau, Ludovic||Arnoux, Philippe||Moussaron, Albert||Acherar, Samir||Baydoun, Martha||Azaïs, Henri||Collinet, Pierre||Mordon, Serge||Delhem, Nadira","18th Congress of the European Society for Photobiology (ESP)",,"Barcelone","Espagne","2019-07",,,,,,,,"Chimie||Sciences du Vivant [q-bio]/Cancer",,"Anglais","Oui","Internationale","Non",,
"fcc0ef72-4828-4659-9400-a8e8458d5523","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)||Communication dans un congrès avec actes",,,,"A Fast and Fully Automated Approach to Segment Optic Nerves on MRI and its application to radiosurgery","Dolz, Jose||Leroy, Henri-Arthur||Reyns, Nicolas||Massoptier, Laurent||Vermandel, Maximilien","12th IEEE International Symposium on Biomedical Imaging",,"New York","Etats-Unis d'Amérique","2015-04-16",,,,,,,"MRI||radiosurgery||optic nerves segmentation||machine learning||support vector machines","Informatique [cs]/Vision par ordinateur et reconnaissance de formes [cs.CV]||Informatique [cs]/Imagerie médicale||Informatique [cs]/Traitement des images [eess.IV]||Sciences du Vivant [q-bio]/Cancer","Delineating critical structures of the brain is required for advanced radiotherapy technologies to determine whether the dose from the proposed treatment will impair the functional-ity of those structures. Employing an automatic segmentation computer module in the radiation oncology treatment planning process has the potential to significantly increase the efficiency , cost-effectiveness, and, ultimately, clinical outcome of patients undergoing radiation therapy. Atlas-based seg-mentation has shown to be a suitable tool for the segmentation of large structures such as the brainstem or the cerebellum. However, smaller structures such as the optic nerves are more difficult to segment. In this work, we present a novel approach to automatically segment the optic nerves, which is based on Support Vector Machines (SVM). Compared to state of the art methods, the presented method obtained a better performance in regards to accuracy, robustness and processing time, being a suitable trade-off between these three factors.","Anglais","Oui","Internationale","Non","Software for the Use of Multi-Modality images in External Radiotherapy",
"be04fbd2-93da-4338-b41b-0a646306e48a","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)||Communication dans un congrès avec actes","10.1016/j.pdpdt.2017.01.169",,,"Preliminary results on 5-ALA PDT fractionation on a preclinical rodent model","Mordon, Serge||Dupont, Clément||Betrouni, N.||Reyns, N.||Vermandel, M.","IPA",,"NANCY","France","2016-10-24",,,,,"2017-03",,,"Sciences du Vivant [q-bio]||Sciences du Vivant [q-bio]/Cancer","Glioblastoma Multiform (GBM) is a high-grade brain tumour with local recurrence and poor outcome. Photodynamic therapy to treat glioblastoma has been recently reported to improve overall survival. However, controlled study to evidence treatment efficacy is still expected and treatment delivery has to be optimized. Several parameters might be optimized such as fluence rate, dose escalation or fractionation of light delivery. Specially, fractionation of light delivery is expected to enhance treatment efficiency by restoring tissue oxygenation. Thus, we have evaluated light fractionation on a preclinical rodent model harbouring grafted GBM. Thirty-nine "" Nude "" rats were grafted with human U87 cells. Cells were stereotactically grafted in rat brain. After the presence and the size of the tumour were assessed by microMRI, PDT was delivered interstitially. Light was delivered through an optical fibre introduced into the tumour after PS precursor intake (5-ALA). The rats were randomized in three groups: (1) without illumination, (2) with 2-steps light fractionation and (3) with 5-steps light fraction-ation. Brain immunohistology and microMRI images were achieved to evaluate the treatment effects. On diffusion MRI, elevated diffusion values in tumour centre among treated animals were observed, especially for the 5-steps fractionation group. Perfusion decreased around the treatment site, especially in the 5-steps fractionation group. Histology confirmed our MRI findings, with a more extensive necrosis and apopto-sis associated with a rarefiedangiogenic network in the treatment area, after 5-steps fractionation PDT. However, more surrounding oedema and neovascularization in the peripheral ring after 5-steps fractionation PDT were also noticed. Finally we observed that interstitial PDT induced more tumour necrosis and apoptosis when applying 5-steps fractionation. However , this scheme also led to significant peripheral oedema and neovascularization. Diffusion and perfusion were able to predict the histological lesions. Nevertheless, apoptosis cells death remains the preferred effect in order to decrease potential side effects. We hypothesize a lower fluence rate with the same light fractionation scheme might increase apoptosis while decreasing necrosis and oedema. Preclinical study is still on going to verify this hypothesis. http://dx.","Anglais","Oui","Internationale","Non",,
"24e46ad3-3fe6-4b55-8101-f910b428d13a","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)||Communication dans un congrès avec actes",,,,"Targeted porphyrins ans nanoparticles for both detection and photodynamic therapy","Frochot, Céline||Acherar, Samir||Azais, Henri||Barberi-Heyob, Muriel||Mordon, Serge||Pinel, Sophie||Vanderesse, Régis","Eighth International Conference on Porphyrins and Phthalocyanines, ICPP-9",,"Nanjing","Chine","2016-07-03",,,,,,,,"Chimie||Sciences du Vivant [q-bio]/Cancer","Photodynamic therapy (PDT) is clinically used to treat different kind of cancers as well as age-related macular degeneration, acne... After excitation of a photo-activable molecule called the photosensitizer and energy transfer to oxygen, reactive oxygen species are produced leading to photooxidation reactions. One limitation of photodynamic therapy is the low selectivity of photosensitizers to tumor tissue compared to normal tissue. The synthesis of photosensitizers especially porphyrins or chlorins coupled with vectors specific of the membrane receptors over-expressed on neo-vessels or tumoral cells has become a center of interest.The poor outcome of primary malignant brain tumors derives from local invasion and local recurrence. Standard treatment of high-grade astrocytic tumors usually consists of cytoreductive surgery followed by radiation techniques and chemotherapy; however these tumor types usually recur despite treatments. In most cases, curative resection is not possible due to infiltrating growth of the tumor into normal brain parenchyma. In this unfavorable context, PDT appears as an innovative technology being investigated to fulfill the need for a targeted cancer treatment that may reduce recurrence and extend survival with minimal side effects. We develop peptide-targeted photosensitizers1,2,3 as well as peptide-targeted nanoparticles4,5,6 to improve the efficiency of PDT to treat glioblastoma.Ovarian cancer’s prognosis remains dire after primary therapy. 60% of women with epithelial ovarian cancer considered in remission will develop recurrent disease within five years. Special attention to undetected peritoneal metastasis during surgery is necessary as they are the main predictive factors of recurrences. Folate Receptor α shows promising prospects in targeting ovarian cancerous cells and intraperitoneal PDT could be a solution in addition to macroscopic cytoreductive surgery to treat peritoneal micrometastasis.We develop new folic acid targeted porphyrin7,8,9. The photodynamic activity of these targeted compounds are evaluated in vitro and in vivo.","Anglais","Oui","Internationale","Non",,
"da12c58a-8df2-42a3-a8ef-bbb9ec0c585b","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)||Communication dans un congrès avec actes",,,"http://hdl.handle.net/20.500.12210/108734","Evaluation of a New Anti-Galectin 9 Immunotherapy Strategy in Pancreatic Cancers","Quilbe, Alexandre||Mustapha, Rami||Renaud, S||Duchêne, Belinda||de Schutter, Clémentine||Herlin, G||Moralès, Olivier||van Seuningen, Isabelle||Jonckheere, Nicolas||Delhem, Nadira","5th European Congress of Immunology",,"Amsterdam","Pays-Bas","2018",,,,,,,,"Sciences du Vivant [q-bio]",,"Anglais","Oui","Internationale","Non",,"Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189"
"bd5bcf7e-de7e-4a17-9f75-f7d0b18b4d4b","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)||Communication dans un congrès avec actes","10.1016/j.pdpdt.2017.01.146",,,"Photodynamic therapy for actinic keratoses: How effective are two white led light doses compared with two standard light doses?","Mordon, Serge||Vignion-Dewalle, S.||Betrouni, N.||Thecua, E.||Vicentini, C.","IPA",,"NANCY","France","2016-10-24",,,,,"2017-03",,,"Sciences du Vivant [q-bio]||Sciences du Vivant [q-bio]/Cancer",,"Anglais","Oui","Internationale","Non",,
"f84635cb-be25-4a63-a0bf-92e7fd67d2d9","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)",,,"http://hdl.handle.net/20.500.12210/108731","Evaluation of a New Anti-Galectin 9 Immunotherapy Strategy in Pancreatic Cancers.","Quilbe, Alexandre||Mustapha, Rami||Renaud, S||Duchêne, Belinda||de Schutter, Clémentine||Herlin, G||Moralès, Olivier||van Seuningen, Isabelle||Jonckheere, Nicolas||Delhem, Nadira","11èmes journées scientifiques du Cancéropôle Nord-Ouest",,"Deauville","France","2018",,,,,,,,"Sciences du Vivant [q-bio]",,"Anglais","Oui","Internationale","Non",,"Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189"
"3ae158b5-2bef-4d27-b7c6-c6e2e5ebc5c3","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)||Communication dans un congrès avec actes","10.1016/j.pdpdt.2017.01.169",,,"Preliminary results on 5-ALA PDT fractionation on a preclinical rodent model","Mordon, Serge||Dupont, Clément||Betrouni, N.||Reyns, N.||Vermandel, M.||Leroy, H.A.||Quidet, M.||Leroux, B.","IPA",,"NANCY","France","2016-10-24",,,,,"2017-03",,,"Sciences du Vivant [q-bio]||Sciences du Vivant [q-bio]/Cancer","Glioblastoma Multiform (GBM) is a high-grade brain tumour with local recurrence and poor outcome. Photodynamic therapy to treat glioblastoma has been recently reported to improve overall survival. However, controlled study to evidence treatment efficacy is still expected and treatment delivery has to be optimized. Several parameters might be optimized such as fluence rate, dose escalation or fractionation of light delivery. Specially, fractionation of light delivery is expected to enhance treatment efficiency by restoring tissue oxygenation. Thus, we have evaluated light fractionation on a preclinical rodent model harbouring grafted GBM. Thirty-nine "" Nude "" rats were grafted with human U87 cells. Cells were stereotactically grafted in rat brain. After the presence and the size of the tumour were assessed by microMRI, PDT was delivered interstitially. Light was delivered through an optical fibre introduced into the tumour after PS precursor intake (5-ALA). The rats were randomized in three groups: (1) without illumination, (2) with 2-steps light fractionation and (3) with 5-steps light fraction-ation. Brain immunohistology and microMRI images were achieved to evaluate the treatment effects. On diffusion MRI, elevated diffusion values in tumour centre among treated animals were observed, especially for the 5-steps fractionation group. Perfusion decreased around the treatment site, especially in the 5-steps fractionation group. Histology confirmed our MRI findings, with a more extensive necrosis and apopto-sis associated with a rarefiedangiogenic network in the treatment area, after 5-steps fractionation PDT. However, more surrounding oedema and neovascularization in the peripheral ring after 5-steps fractionation PDT were also noticed. Finally we observed that interstitial PDT induced more tumour necrosis and apoptosis when applying 5-steps fractionation. However , this scheme also led to significant peripheral oedema and neovascularization. Diffusion and perfusion were able to predict the histological lesions. Nevertheless, apoptosis cells death remains the preferred effect in order to decrease potential side effects. We hypothesize a lower fluence rate with the same light fractionation scheme might increase apoptosis while decreasing necrosis and oedema. Preclinical study is still on going to verify this hypothesis. http://dx.","Anglais","Oui","Internationale","Non",,
"eea9c800-6d4e-4552-89d4-a85662d471f2","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)||Communication dans un congrès avec actes",,,"http://hdl.handle.net/20.500.12210/108736","Evaluation of a New Anti-Galectin 9 Immunotherapy Strategy in Pancreatic Cancers.","Quilbe, Alexandre||Mustapha, Rami||Duchêne, Belinda||Renaud, S||de Schutter, Clémentine||Moralès, Olivier||Jonckheere, Nicolas||van Seuningen, Isabelle||Delhem, Nadira","Club Français du Pancréas",,"Bron","France","2019",,,,,,,,"Sciences du Vivant [q-bio]",,"Anglais","Oui","Internationale","Non",,"Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189"
"d48bef00-0fae-42a8-9ae7-3c4a0af26327","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)||Communication dans un congrès avec actes",,,,"Devices based on Light Emitting Fabrics dedicated to PDTpreclinical studies","Thecua, E||Ziane, L||Baert, G||Deleporte, P.||Leroux, B.||Kumar, A.||Baydoun, M||Morales, O||Delhem, N||Mordon, Serge","""The Feminine"" 51st IPA Congress",,"Londres","Royaume-Uni","2019-07-24",,,,,,,"Light emitting fabrics||textile||optical||fibers||bending||PDT||preclinical studies||illumination||MDB TEXINOV","Sciences du Vivant [q-bio]||Sciences du Vivant [q-bio]/Cancer||Sciences du Vivant [q-bio]/Ingénierie biomédicale","Whether preclinical studies either involve a cell or animalmodel, the distribution of light plays a determinant role in the reproducibility of results of photodynamic therapy (PDT) studies. Unfortunately, only few illumination devices dedicated to preclinical studies are available and are for the most, very expensive. Mostresearch teams use home-made solutions that may not always be reproducible because of undefined light distribution, additive thermal emission, or unsuitable for shapes and volumes to illuminate. To address these issues, we developed illumination devices dedicated to our preclinical studies, which embed knitted light emitting fabrics (LEF) technology. LEF technology offers a homogeneous light distribution, without thermal emission and can be coupled with various light sources allowinginvestigation of several PDT modalities (irradiance, wavelength, illumination duration/mode). For in-vitro studies, we designed light plates,each allowing illumination of up to four 96-cells plates. For in-vivo studies, we designed mice boxes allowing three animals placement in prone position, equally surrounded by LEF and ensuring homogeneous extracorporeal illumination. Optical validation was performed and reproducibility of both preclinical systems were assessed. Both systems can deliver homogeneous light with an irradiance that can reachseveral mW/cm 2 , with varying durations and wavelengths. First results of preclinical studies demonstrate a high reproducibility, with an easy setup, and a great adaptability of illumination modalities with these devices based on light emitting fabrics.","Anglais","Oui","Internationale","Non",,
"230557a0-c54b-4fe0-bb7b-540966fcafd5","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)",,,,"18-FDG PET-CT diagnostic value in immune checkpoint inhibitor-induced myositis","Mensi, Samy||Chassepot, Horstense||Kharroubi, Dris||Plomp, Lotta||Abbar, Baptiste||Kas, Aurélie||Spano, Jean-Philippe||Leonard-Louis, Sarah||Seilhean, Danielle||Benveniste, Olivier||Salem, Joe-Elie||Allenbach, Yves","4th Global Conference On Myositis (GCOM 2022)",,"Prague","République tchèque","2022-06-06",,,,,,,,"Sciences du Vivant [q-bio]",,"Anglais","Oui","Internationale","Non",,
"6d1aab36-0303-4dd0-9f13-86d0d825ebc1","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)||Communication dans un congrès avec actes",,,,"DOSINDYGO -DOSe finding for INtraoperative photoDYnamic therapy of GliOblastoma","Dupont, C.||Lecomte, F.||Deleporte, P.||Baert, G||Mordon, Serge||Reyns, N.||Vermandel, M.","17th International Photodynamic Association World Congress",,"Cambridge, Massachusetts","Etats-Unis d'Amérique","2019-06-28",,,,,,,"photodynamic therapy||glioblastoma||clinical trial||light dose escalation","Sciences du Vivant [q-bio]||Sciences du Vivant [q-bio]/Cancer||Sciences du Vivant [q-bio]/Ingénierie biomédicale","Glioblastoma is a malignant brain tumor with a poor prognosis. Currently, complete resection is rarely feasible, since tumor cells usually infiltrate the surrounding brain. Recently, the INDYGO clinical trial has been achieved to assess the toxicity of photodynamic therapy (PDT) delivered intraoperatively to treat newly diagnosed glioblastoma. Today, we believe that the PDT effect obtained in the INDYGO clinical trial can be improved by a higher light dose. The DOSINDYGO clinical trial aims to achieve a light-dose escalation increasing up to four times the initial light dose used in the INDYGO trial. An increase of both light power and treatment time should allow to treat deeper in the surrounding tissues (up to 8mm) and thus decrease the recurrence risk. First light dose will be reached by doubling the treatment time used in the INDYGO trial, the other one will be achieved by increasing light power only. This methodology was chosen in order to maintain an acceptable treatment time for anesthesia but also to prevent higher fluence rate that could induce a lower tolerance as observed in our preclinical results. Primary endpoint will be to determine the optimum light-dose regarding the ratio efficacy and tolerance of the treatment. Primary criterion is the assessment of the progression free survival within the bed border's cavity. Finally, although no adverse effect has been noticed during the INDYGO trial, increasing light dose in this DOSINDYGO trial could result in other direct and indirect biological effects.","Anglais","Oui","Internationale","Non",,
"63537b53-d690-4ebf-ae40-583718ce280f","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)||Communication dans un congrès avec actes",,,,"LIGHT EMITTING FABRICS FOR PHOTODYNAMIC TREATMENT OF VULVAR PRIMARY EXTRAMAMMARY PAGET'S DISEASE","Thecua, E||Lecomte, F||Ziane, L||Vignion, A-S||Maire, C||Vicentini, C||Abirached, H||Staumont, D||Mortier, L||Mordon, Serge","""The Feminine"" 51st IPA Congress",,"Londres","Royaume-Uni","2019-07-24",,,,,"2019-08-07",,"Light emitting fabrics||textile||Extramammary Paget's disease||photodynamic therapy","Sciences du Vivant [q-bio]||Sciences du Vivant [q-bio]/Cancer||Sciences du Vivant [q-bio]/Ingénierie biomédicale","Primary Extramammary Paget's disease (EMPD) is a rare cancer that mainly affects the genital region including vulvar and perianal areas. Without treatment, vulvar EMPD progresses and presents always more erythematous and pruritic plaques, which may become ulcerated and erosive. To control disease progression and symptoms usually experienced by patients, surgical excision is the mainstay of treatment. Unfortunately, even after large surgical excision with intra-operative margin control, recurrences are common [1]. For recurrent patients which undergo multiple resections, severe functional and sexual alterations are described. Only few data are available on the efficacy of alternative conservative treatments, such as laser ablation, radiotherapy, topical chemotherapy and photodynamic therapy (PDT) [2]. To date, none of them can be considered as a solid alternative to surgical excision yet [3]. Nonetheless, multiple clinical cases suggest that PDT could provide the opportunity to treat subclinical lesions, and give some relief on patient's symptoms of the disease [4-6]. Unfortunately, the benefits of using photodynamic therapy for vulvar EMPD remains a challenge to demonstrate, because of the inhomogeneous illumination of vulvar and perianal areas, and the extreme pain that patients usually experienced during the illumination procedure that may lead to premature end of treatment [7, 8]. Resulting from the knowledge of previous works on actinic keratosis of the scalp treatment with PDT, light emitting fabrics (LEF) technology could address both of the hereinbefore described issues [9-12]. A new medical device based on LEF named PAGETEX® dedicated to illumination of vulvar and perianal areas has been developed. The device delivers a homogeneous red light (635 nm) with a low irradiance during 2h30, for a total fluence of 12 J/cm². The PAGETEX® device is being assessed in a clinical study (NCT03713203) which aims to establish PAGETEX®-PDT efficacy and tolerability.","Anglais","Oui","Internationale","Non",,
"eb807753-a9c4-444a-a5f3-a841fd90c4de","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)||Communication dans un congrès avec actes",,,"http://hdl.handle.net/20.500.12210/108735","Evaluation of a New Anti-Galectin 9 Immunotherapy Strategy in Pancreatic Cancers","Quilbe, Alexandre||Mustapha, Rami||Renaud, S||Duchêne, Belinda||de Schutter, Clémentine||Herlin, G||Moralès, Olivier||van Seuningen, Isabelle||Jonckheere, Nicolas||Delhem, Nadira","4ème Journée Scientifique de l’Association pour la Recherche sur le Cancer du pancréas (AFRCP)",,"Clichy","France","2018",,,,,,,,"Sciences du Vivant [q-bio]",,"Anglais","Oui","Internationale","Non",,"Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189"
"692182c6-6925-4317-92b2-81966a4a3afd","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)||Communication dans un congrès avec actes","10.1016/j.pdpdt.2017.01.170",,,"Illumination profile characterization of a light applicator","Mordon, Serge||Munck, C.||Betrouni, N.","IPA",,"NANCY","France","2016-10-24",,,,,"2017-03",,,"Sciences du Vivant [q-bio]||Sciences du Vivant [q-bio]/Cancer",,"Anglais","Oui","Internationale","Non",,
"56cc0dc0-8454-40a0-a0b4-9b488906ad2b","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)||Communication dans un congrès avec actes",,,,"Photodynamic therapy for actinic keratosis: a trend towards a decrease in irradiance without loss of efficacy for a better tolerability","Vignion-Dewalle, Anne-Sophie||Vicentini, Claire||Baert, Grégory||Thecua, Elise||Lecomte, Fabienne||Mortier, Laurent||Mordon, Serge","17th International Photodynamic Association World Congress",,"Cambridge, Massachusetts","Etats-Unis d'Amérique","2019-06-28",,,,,,,"Photodynamic therapy||actinic keratosis||Aktilite CL128||irradiance||complete response","Sciences du Vivant [q-bio]||Sciences du Vivant [q-bio]/Cancer||Sciences du Vivant [q-bio]/Ingénierie biomédicale||Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Dermatologie","Photodynamic therapy (PDT) is an established treatment for actinic keratosis (AK). The conventional approved PDT protocol in Europe (C-PDT) involves red-light photoactivation at irradiances higher than 60 mW/cm 2 , making the treatment painful. Several clinical studies have reported similar efficacy and better tolerability when using red-light photoactivation at lower irradiances. The aim of the study was to investigate whether there is a minimum irradiance threshold for red-light photoactivation above which there is no further improvement in efficacy. A photodiode sensor connected to a power meter was used to measure the irradiance delivered to 114 AKs on the scalp and forehead of 19 patients during C-PDT using the Aktilite CL 128 (Galderma SA, Switzerland). The widely ranging measured irradiances, resulting from the heterogeneous photoactivation over the treatment area provided by the Aktilite CL 128, were cross-referenced with the clinically evaluated complete responses (CR) at 3 months. The 66 AKs in CR at 3 months received an average irradiance of 30.9 mW/cm 2 (standard deviation: 16.7 mW/cm 2) compared to 33.3 mW/cm 2 (standard deviation: 17.9 mW/cm 2) for the 48 AKs in incomplete response. No significant effect of the irradiance on the CR at 3 months was found (odds ratio for a 6 mW/cm 2-unit change, 0.96; 95% confidence interval, 0.83 to 1.10; p=0.53). No minimum irradiance threshold could therefore be determined in the considered irradiance range. A red-light device enabling homogeneous irradiation at a lower irradiance than the Aktilite CL 128 may therefore provide similar efficacy and higher treatment tolerability than C-PDT.","Anglais","Oui","Internationale","Non",,
"300c2a54-a915-42b4-bd79-7a77e7d45ce8","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)||Communication dans un congrès avec actes",,,,"PDT in dermatology: quantification, relevance and comparison of light sources within a few clicks","Vignion-Dewalle, Anne-Sophie||Baert, Grégory||Thecua, Elise||Lecomte, Fabienne||Vicentini, Claire||Mortier, Laurent||Mordon, Serge","17th International Photodynamic Association World Congress",,"Boston Marriott Cambridge Cambridge, Massachusetts,","Etats-Unis d'Amérique","2019-06-28",,,,,,,"Photodynamic therapy||light sources||actinic keratoses||protoporphyrin IX||PpIX-weighted irradiance||website","Sciences du Vivant [q-bio]||Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Dermatologie||Sciences du Vivant [q-bio]/Cancer","Photodynamic therapy (PDT) for dermatological conditions relies on the photoactivation of the photosensitizer protoporphyrin IX (PpIX). Many light sources have been or are being investigated. The stronger the overlap of the spectral irradiance of the light source with the absorption spectrum of PpIX is, the more powerful to photoactivate PpIX is the light source. This overlap can be quantified using the PpIX-weighted irradiance, which results from the weighting of the spectral irradiance of the light source by the normalized PpIX absorption spectrum. We have previously developed a freely available website (http://www.oncothai.fr/light-efficiency-calculator/), which aims to compute the PpIX-weighted irradiance of any uploaded spectral irradiance. Through this website, we have assessed a variety of light sources proposed for use in dermatological PDT. The spectral irradiances of these light sources were collected either by extraction from the literature or request to manufacturers. Due to the variations in position, shape, and amplitude of the spectral irradiances with regard to the PpIX normalized absorption spectrum, a wide range of PpIX-weighted irradiances has been obtained. The maximal PpIX-weighted irradiance was achieved with daylight on a clear sunny day.","Anglais","Oui","Internationale","Non",,
"df7d1dd6-3657-448e-9aee-e4654a4b381f","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)||Communication dans un congrès avec actes",,,,"Probability map prediction of relapse areas in glioblastoma patients using multi-parametric MR","Laruelo, Andrea||Dolz, Jose||Ken, Soleakhena||Chaari, Lotfi||Vermandel, Maximilien||Massoptier, Laurent||Laprie, Anne","ESTRO 35 Radiotherapy and Oncology",,"Turin","Italie","2016-04-29",,,,,"2016-04-29",,"machine learning||SVM||Recurrence tumor prediction||Glioblastome","Informatique [cs]/Intelligence artificielle [cs.AI]||Informatique [cs]/Vision par ordinateur et reconnaissance de formes [cs.CV]||Informatique [cs]/Imagerie médicale||Informatique [cs]/Apprentissage [cs.LG]","Purpose: Despite post-operative radiotherapy (RT) of glioblastoma (GBM), local tumor regrowth occur in irradiated areas and are responsible for poor outcome. Identification of sites with high probability of recurrence is a promising way to define new target volumes for dose escalation in RT treatments. This study aims at assessing the value of multi-parametric magnetic resonance (mp-MR) data acquired before RT treatment in the identification of regions at risk of relapse. Methods: Ten newly diagnosed GBM patients included in a clinical trial, treated in the reference arm of 60 Gy and Temozolomide, underwent magnetic resonance imaging (MRI) and MR spectroscopy (MRSI) before RT treatment and every 2 months until relapse. Quantification of MRSI was improved following the spatio-spectral regularization approach proposed in [1]. The site of relapse was considered as the new appearing contrast-enhancing (CE) areas on T1-weighted images after gadolinium injection (T1-Gd). Using a set of mp-MR data acquired before RT treatment as input, a supervised learning system was trained to generate a probability map of CE appearance of GBM. Since it has recently shown a great performance in some other brain-related classification problems, such as segmentation of brain tumor [2] or some brain structures [3], support vector machines (SVM) [4] was chosen as the learning technique. To fed the classifier, T1-Gd and FLAIR image intensities, Choline-over-NAA, Choline-over-Creatine and Lac-over-NAA metabolite ratios, and metabolite heights were used. The resolution of the MRI images was lowered to the one of the MRSI grid by averaging MRI pixel intensities within each MRSI voxel (400 MRSI voxels were considered for each subject). The region of CE was manually contoured on both the pre-RT and post-RT T1-Gd images by experienced medical staff. All voxels that enhanced at the pre-RT exam were excluded from further consideration. The learning system was trained and tested using leave-one-out-cross-validation (LOOCV) with all the patients. A grid-search strategy was employed for parameter optimization. Results: For comparison purposes, generated probability maps were thresholded with a value of 0.5. Thus, only voxels with values higher than 0.5 on the probability map were considered as relapse. The sensitivity and specificity of the proposed system were 0.80 (0.19) and 0.87 (0.09), respectively. For our data, standard Choline-to-NAA index (CNI) achieved a sensitivity of 0.62 (0.25) and a specificity of 0.63 (0.13). In addition, the receiver operating characteristic (ROC) curve also shows that the presented approach outperforms CNI (Fig 1.). The SVM-based results had lower variation across patients than CNI. An example of a probability map of relapse areas generated by the proposed approach is shown in Fig.2. Relapse regions predicted by the learning scheme are in high accordance with the manually contoured region. Conclusions: A learning system based on SVM trained with mp-MR data has been presented. Reported results imply that this learning scheme can provide a probability map of the area of relapse of GBM in a stable and accurate manner, as shown in Fig.1. This study suggests the potential of multi-parametric MR data in addressing specific questions in GBM imaging.","Anglais","Oui","Internationale","Non",,
"6a00d1be-96e8-4464-a1a3-c51549622449","20.500.12210/13","Autre communication scientifique (congrès sans actes - poster - séminaire...)||Communication dans un congrès avec actes",,,,"Light emitting fabrics for PDT: technology and results of clinical studies","Mordon, Serge||Thecua, Elise||Lecomte, Fabienne||Vignion-Dewalle, Anne||Deleporte, Pascal||Maire, Cyril||Abi-Rached, Henry||Vicentini, Claire||Hommel, Theresa||Szeimies, R||Mortier, Laurent","17th International Photodynamic Association World Congress",,"Cambridge, Massachusetts","Etats-Unis d'Amérique","2019-06-28",,,,,,,"Photodynamic Therapy||Light Emitting Fabric||Textile||Laser||Actinic Keratosis||Clinical Evaluation","Sciences du Vivant [q-bio]||Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Dermatologie||Sciences du Vivant [q-bio]/Cancer","A homogeneous and reproducible fluence rate delivery during clinical PDT plays a determinant role in preventing under-or overtreatment. In Dermatology, topical PDT has been carried out with a wide variety of light sources delivering a broad range of light doses. However, these light sources do not deliver a uniform light distribution on the skin due to their structure and morphology and the complexities of the human anatomy. The development of a flexible light source able to generate uniform light on all its surface would considerably improve the homogeneity of light delivery. The integration of plastic optical fibers (POF) into textile structures offers an interesting alternative. The homogeneous light side-emission from the fabric is obtained by controlling the bending angles of POF inside the LEF due to specific architecture generated by knitting of textile structure. LEF of different surfaces can be easily manufactured (up to 500cm² The LEF thickness is less than 1 mm. The mean irradiance is typically 2.5 mW.cm-².W-1 with heterogeneity of 12.5 % at any point of the LEF. The temperature elevation remains below 1°C. These LEF were evaluated in Dermatology for the treatment of Actinic Keratosis. Two clinical evaluation were performed. The first one was a monocentric, randomized, controlled, phase II clinical study (ClinicalTrials.gov Identifier: NCT03076918). Twenty five (25) patients with grade I-II actinic keratosis (AK) of the forehead and scalp were treated with methyl aminolevulinate photodynamic therapy in two symmetrical areas. One area was treated with the conventional LED panel (154 AK), whereas the other area was treated with the LEF device (156 AK). The second clinical was performed in 2 centers. This new LEF device was a more ergonomic and compact version of the original system developed for FLEXI-PDT. In this clinical study (ClinicalTrials.gov Identifier: NCT03076892), the irradiance has been reduced from 12.3 mW/cm 2 to 1.3 mW/cm 2 and the light dose from 37 J/cm 2 to 12 J/cm 2. Compared to Conventional PDT, the 2 protocols clearly shown that LEF are equivalent and even superior in terms of efficacy for treating AK of the forehead and scalp. However, the use of LEF resulted in much lower pain scores and fewer adverse effects. In conclusion, thanks to LEF, PDT of AK can be conducted in all weather conditions, in any geographic location, year-round and benefits from the optimal adaptability of the flexible, light-emitting, fabrics to the treatment area. At last, LEF can be easily can be easily manufactured in large series.","Anglais","Oui","Internationale","Non",,
