Title :

Decrease of lethal infectious complications in the context of causes of death (COD) after hematopoietic cell transplantation: COD-2 and COD-1 study of the Infectious Diseases Working Party EBMT.

Author(s) :

Styczynski, Jan [Auteur]
Nicolaus Copernicus University [Toruń]
Tridello, Gloria [Auteur]
Leiden University Medical Center [LUMC]
Azienda Ospedaliera Universitaria Integrata of Verona
Koster, Linda [Auteur]
Leiden University Medical Center [LUMC]
Knelange, Nina [Auteur]
Leiden University Medical Center [LUMC]
Wendel, Lotus [Auteur]
Leiden University Medical Center [LUMC]
Van Biezen, Anja [Auteur]
Leiden University Medical Center [LUMC]
Van Der Werf, Steffie [Auteur]
Leiden University Medical Center [LUMC]
Mikulska, Malgorzata [Auteur]
Ospedale Policlinico San Martino [Genoa]
Gil, Lidia [Auteur]
Poznan University of Medical Sciences [Poland] [PUMS]
Cordonnier, Catherine [Auteur]
Hôpital Henri Mondor
Ljungman, Per [Auteur]
Karolinska University Hospital [Stockholm]
Averbuch, Diana [Auteur]
Hadassah Hebrew University Medical Center [Jerusalem]
Cesaro, Simone [Auteur]
Università degli studi di Verona = University of Verona [UNIVR]
Baldomero, Helen [Auteur]
University Hospital Basel [Basel]
Chabannon, Christian [Auteur]
Institut Paoli-Calmettes [IPC]
Corbacioglu, Selim [Auteur]
University of Regensburg
Dolstra, Harry [Auteur]
Radboud University Medical Center [Nijmegen]
Glass, Bertram [Auteur]
Helios Klinikum [Erfurt]
Greco, Raffaella [Auteur]
IRCCS Ospedale San Raffaele [Milan, Italy]
Kröger, Nicolaus [Auteur]
University Hospital Hamburg-Eppendorf
Peffault de Latour, Régis [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Mohty, Mohamad [Auteur]
CHU Saint-Antoine [AP-HP]
Neven, Benedicte [Auteur]
Hôpital Necker - Enfants Malades [AP-HP]
Peric, Zinaida [Auteur]
University Hospital Centre Zagreb
Snowden, John A. [Auteur]
Sheffield Children's NHS Foundation Trust
Sureda, Anna [Auteur]
Institut d'Investigació Biomèdica de Bellvitge = Bellvitge Biomedical Research Institute [IDIBELL]
Yakoub-Agha, Ibrahim [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
De La Camara, Rafael [Auteur]
Hospital Universitario de La Princesa

Journal title :

Bone Marrow Transplantation

Abbreviated title :

Bone Marrow Transplant

Publication date :

2023-05-08

ISSN :

1476-5365

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

We previously analyzed trends in incidence and factors associated with lethal complications in ALL/AML/CML patients (causes of deaths; COD-1 study). The objective of this study was the analysis of incidence and specific ...
Show more >We previously analyzed trends in incidence and factors associated with lethal complications in ALL/AML/CML patients (causes of deaths; COD-1 study). The objective of this study was the analysis of incidence and specific causes of death after HCT, with focus on infectious deaths in two time periods, 1980–2001 (cohort-1) and 2002–2015 (cohort-2). All patients with HCT for lymphoma, plasma cell disorders, chronic leukemia (except CML), myelodysplastic/myeloproliferative disorders, registered in the EBMT-ProMISe-database were included (n = 232,618) (COD-2 study). Results were compared to those in the ALL/AML/CML COD-1 study. Mortality from bacterial, viral, fungal, and parasitic infections decreased in very early, early and intermediate phases. In the late phase, mortality from bacterial infections increased, while mortality from fungal, viral, or unknown infectious etiology did not change. This pattern was similar for allo- and auto-HCT in COD-1 and COD-2 studies, with a distinct and constant lower incidence of all types of infections at all phases, after auto-HCT. In conclusion, infections were the main cause of death before day +100, followed by relapse. Mortality from infectious deaths significantly decreased, except late phase. Post-transplant mortality has significantly decreased in all phases, from all causes after auto-HCT; it has decreased in all phases after allo-HCT except late phase.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-11T22:49:34Z
2024-03-06T08:43:44Z