\"Alcohol-associated liver disease: integrated management with alcohol use disorder\".

Arab, Juan P.; Addolorato, Giovanni; Mathurin, Philippe; Thursz, Mark R.

Document type :

Article dans une revue scientifique: Article de synthèse/Review paper

DOI :

10.1016/j.cgh.2023.02.017

PMID :

36858144

Permalink :

http://hdl.handle.net/20.500.12210/100623

Title :

\"Alcohol-associated liver disease: integrated management with alcohol use disorder\".

Author(s) :

Arab, Juan P. [Auteur]
Pontificia Universidad Católica de Chile [UC]
University of Western Ontario [UWO]
Addolorato, Giovanni [Auteur]
Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] [Unicatt]
Mathurin, Philippe [Auteur]

Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Thursz, Mark R. [Auteur]
Imperial College London

Journal title :

Clinical Gastroenterology and Hepatology

Abbreviated title :

Clin Gastroenterol Hepatol

Publication date :

2023-03-03

ISSN :

1542-7714

English keyword(s) :

Alcohol
Cirrhosis
Alcohol-Associated Hepatitis
Alcohol Use Disorder
Fatty Liver Disease

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Alcohol-associated liver disease (ALD) is the most common cause of cirrhosis and liver-related mortality in many regions worldwide. Around 75% of patients with cirrhosis are unaware of their disease until they are referred ...
Show more >Alcohol-associated liver disease (ALD) is the most common cause of cirrhosis and liver-related mortality in many regions worldwide. Around 75% of patients with cirrhosis are unaware of their disease until they are referred to the emergency department. An innovative, noninvasive screening approach is required for an earlier diagnosis of liver fibrosis. In patients with ALD the physician is inevitably dealing with 2 major disorders: the liver disease itself and the alcohol use disorder (AUD). Focus only on the liver disease will inevitably lead to failure because transient improvements in liver function are rapidly overturned if the patient returns to alcohol consumption. For this reason, integrated models of care provided by hepatologists and addiction specialists are an effective approach, which are, however, not widely available. There are multiple pharmacologic and non-pharmacologic therapies for AUD. Progress has recently been made in the management of patients with severe AH who have improved survival through better understanding of the concept of response to medical treatment, improved survival prediction, and the advent of early liver transplantation. The emerging concept is that listing for transplantation a patient with severe ALD could lead to adjusting the duration of abstinence according to the severity and evolution of liver dysfunction and the patient’s addictive profile.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-11T23:15:09Z
2024-03-26T10:36:46Z

Version	Link	Modification date
2	20.500.12210/100623*	2024-03-26T10:34:44Z
1	20.500.12210/100623.1	2024-01-11T23:15:09Z

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\"Alcohol-associated liver disease: ...

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