Title :

Specificities of Meningitis and Meningo-Encephalitis After Kidney Transplantation: A French Retrospective Cohort Study.

Author(s) :

Tamzali, Yanis [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Scemla, Anne [Auteur]
Hôpital Necker - Enfants Malades [AP-HP]
Bonduelle, Thomas [Auteur]
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
Garandeau, Claire [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Gilbert, M. [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Randhawa, Sunny [Auteur]
Hôpital de la Conception [CHU - APHM] [LA CONCEPTION]
De Nattes, Tristan [Auteur]
CHU Rouen
Hachad, Hafsah [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Pourcher, Valérie [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Taupin, P. [Auteur]
Hôpital Necker - Enfants Malades [AP-HP]
Kaminski, Hannah [Auteur]
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
Hazzan, Marc [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Moal, Valérie [Auteur]
Hôpital de la Conception [CHU - APHM] [LA CONCEPTION]
Matignon, Marie [Auteur]
Hôpital Henri Mondor
Fihman, Vincent [Auteur]
Hôpital Henri Mondor
Dynamic Microbiology - EA 7380 [DYNAMIC]
Levi, Charlène [Auteur]
Hôpital Edouard Herriot [CHU - HCL]
Le Quintrec, Moglie [Auteur]
Centre Hospitalier Régional Universitaire [Montpellier] [CHRU Montpellier]
Chemouny, Jonathan M. [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Rondeau, Eric [Auteur]
CHU Tenon [AP-HP]
Bertrand, Dominique [Auteur]
CHU Rouen
Thervet, Eric [Auteur]
Hôpital Européen Georges Pompidou [APHP] [HEGP]
Tezenas Du Montcel, Sophie [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Savoye, Emilie [Auteur]
Agence de la biomédecine [Saint-Denis la Plaine]
Barrou, Benoit [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Kamar, Nassim [Auteur]
Université Toulouse III - Paul Sabatier [UT3]
Tourret, Jérôme [Auteur]
CHU Pitié-Salpêtrière [AP-HP]

Journal title :

Transplant International

Abbreviated title :

Transpl Int

Volume number :

36

Pages :

10765

Publication date :

2023-02-07

ISSN :

1432-2277

English keyword(s) :

enterobacteriales
Cryptococcus neoformans
encephalitis
meningitis
opportunistic infections
transplant infectious diseases
immunosuppression
kidney transplantation

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Kidney transplant recipients develop atypical infections in their epidemiology, presentation and outcome. Among these, meningitis and meningoencephalitis require urgent and adapted anti-infectious therapy, but published ...
Show more >Kidney transplant recipients develop atypical infections in their epidemiology, presentation and outcome. Among these, meningitis and meningoencephalitis require urgent and adapted anti-infectious therapy, but published data is scarce in KTRs. The aim of this study was to describe their epidemiology, presentation and outcome, in order to improve their diagnostic and management. We performed a retrospective, multicentric cohort study in 15 French hospitals that included all 199 cases of M/ME in KTRs between 2007 and 2018 (0.9 case per 1,000 KTRs annually). Epidemiology was different from that in the general population: 20% were due to Cryptococcus neoformans, 13.5% to varicella-zoster virus, 5.5% to Mycobacterium tuberculosis, and 4.5% to Enterobacteria (half of which produced extended spectrum beta-lactamases), and 5% were Post Transplant Lymphoproliferative Disorders. Microorganisms causingM/ME in the general population were infrequent (2%, for Streptococcus pneumoniae) or absent (Neisseria meningitidis). M/ME caused by Enterobacteria, Staphylococci or filamentous fungi were associated with high and early mortality (50%–70% at 1 year). Graft survival was not associated with the etiology of M/ME, nor was impacted by immunosuppression reduction. Based on these results, we suggest international studies to adapt guidelines in order to improve the diagnosis and the probabilistic treatment of M/ME in SOTRs.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-11T23:22:25Z
2024-02-28T13:47:48Z