Title :

Multicenter study to assess surgical treatments of 452 sinonasal intestinal-type adenocarcinomas: A REFCOR study.

Author(s) :

De Gabory, Ludovic [Auteur]
Université de Bordeaux [UB]
Waubant, Alice [Auteur]
Université de Bordeaux [UB]
Verillaud, Benjamin [Auteur]
Hôpital Lariboisière-Fernand-Widal [APHP]
Michel, Justin [Auteur]
CHU Marseille
Malard, Olivier [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Rumeau, Cécile [Auteur]
Université de Lorraine [UL]
Jankowski, Roger [Auteur]
Centre Hospitalier Régional Universitaire de Nancy [CHRU Nancy]
Moya-Plana, Antoine [Auteur]
Institut Gustave Roussy [IGR]
Vergez, Sebastien [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Favier, Valentin [Auteur]
CHU Montpellier = Montpellier University Hospital
Mortuaire, Geoffrey [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Righini, Christian [Auteur]
Patron, Vincent [Auteur]
Thariat, Juliette [Auteur]
Centre Régional de Lutte contre le Cancer François Baclesse [Caen] [UNICANCER/CRLC]
Dupin, Charles [Auteur]
Centre Hospitalier Universitaire de Bordeaux [CHU Bordeaux]
Coelho, Julien [Auteur]
Bordeaux population health [BPH]
Bénard, Antoine [Auteur]
Bordeaux population health [BPH]

Journal title :

EJSO - European Journal of Surgical Oncology

Abbreviated title :

Eur J Surg Oncol

Volume number :

49

Pages :

39-46

Publication date :

2022-08-24

ISSN :

1532-2157

English keyword(s) :

Adenocarcinoma
Sinus cancer
Nasal cancer
Endoscopic sinus surgery
Wood dust
REFCOR

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Purpose The objective was to assess the local oncological outcomes of endoscopic versus external surgical treatment of sinonasal intestinal-type adenocarcinomas (ITAC) and the factors of recurrence. Methods a retrospective ...
Show more >Purpose The objective was to assess the local oncological outcomes of endoscopic versus external surgical treatment of sinonasal intestinal-type adenocarcinomas (ITAC) and the factors of recurrence. Methods a retrospective non-randomized case-control multicenter study was carried out, including 452 untreated sinonasal ITACs recruited from 10 tertiary referral centers. The tumors were re-classified according to the UICC 2017 (pT). Survival curves were obtained using the Kaplan-Meier method. Univariate analysis was done with the log-rank test. Multivariate analysis was performed with a Cox model adjusted for age, T stage, and radiotherapy. A binary logistic regression compared surgical complications and performed two supplementary analyses on positive margins. Results We compared 195 and 257 patients operated by the external and endoscopic approach, respectively. The mean follow-up was 59.2 ± 48.7 months. Post-operative margins were invaded in 30.6 versus 18.9% of patients, respectively (p = 0.007). The overall recurrence rate was 33.8 versus 24.6%, respectively (p = 0.034). There was a significant difference in favor of the endoscopic approach regarding local recurrence-free survival thanks to better surgical margins in univariate and multivariate analysis (Odd Ratio = 2.01 (1.2–3.36) p = 0.0087). The complication rate (Odds Ratio = 3.4 (1.79–6.32) p < 0.001) was significantly lower in the endoscopic group. The histological positivity of signet-ring cells shows a statistically significant difference in recurrence-free survival (p = 0.0028). Conclusion the oncological control of ITAC is better through the endoscopic approach, with negative margins and the absence of signet-ring-cells, two independent factors of recurrence.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-12T00:47:39Z
2024-03-26T14:30:54Z