Title :

Gender differences in primary antiphospholipid syndrome with vascular manifestations in 433 patients from four European centres.

Author(s) :

Moschetti, L. [Auteur]
Dal Pozzolo, L. [Auteur]
Le Guern, V. [Auteur]
Service de médecine interne et centre de référence des maladies rares [CHU Cochin]
Morel, N. [Auteur]
Service de médecine interne et centre de référence des maladies rares [CHU Cochin]
Yelnik, Cécile Marie [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE]
Lambert, Marc [Auteur]
Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
Hachulla, Eric [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Benhamou, Y. [Auteur]
Service de Médecine Interne [CHU Rouen]
Endothélium, valvulopathies et insuffisance cardiaque [EnVI]
Université de Rouen Normandie [UNIROUEN]
Nalli, C. [Auteur]
Fredi, M. [Auteur]
Franceschini, F. [Auteur]
Andreoli, L. [Auteur]
Costeadot-Chalumeau, N. [Auteur]
Service de médecine interne et centre de référence des maladies rares [CHU Cochin]
Tincani, A. [Auteur]

Journal title :

Clinical and experimental rheumatology

Abbreviated title :

Clin Exp Rheumatol

Publication date :

2022-03-30

ISSN :

0392-856X

English keyword(s) :

antiphospholipid syndrome
vascular involvement
gender differences
thrombotic risk factors
antiphospholipid antibodies

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVES: Gender can influence incidence and clinical course of autoimmune diseases (ADs). Antiphospholipid syndrome (APS) is a rare AD characterised by thromboses and/or pregnancy morbidities and antiphospholipid ...
Show more >OBJECTIVES: Gender can influence incidence and clinical course of autoimmune diseases (ADs). Antiphospholipid syndrome (APS) is a rare AD characterised by thromboses and/or pregnancy morbidities and antiphospholipid antibodies (aPL) positivity. Our aim is to conduct a gender-oriented analysis of primary thrombotic APS (t-APS). METHODS: Consecutive patients diagnosed with primary t-APS, followed from 1967 to 2019 in four European Centres, were enrolled. RESULTS: The cohort included 296 women and 137 men. Median age at onset [31 (24-46) vs. 41 (29-53) years, p<0.001] was lower in females. In women, venous thromboses were more frequent while, among males, arterial events prevailed. During follow-up, 14% of patients suffered at least two relapses and this occurred especially among males (22% vs. 10%, p=0.001). No gender differences were found in the aPL profile (33% single, 24% double and 43% triple aPL positivity). Most patients had concomitant risk factors (RFs) for thrombosis: established cardiovascular RFs were represented especially among men while estrogenic exposure was the main RF in women. CONCLUSIONS: Women presented mostly with venous thromboses at a younger age, while men with arterial events, later in life and suffered more recurrent events. This different frequency of arterial and venous thromboses could be attributed mainly to the presence of additional RFs rather than to biological gender-specific issues. However, some RFs are exclusive or more represented in one gender rather than the other, so assessing the link of causality between gender and manifestations of t-APS remains difficult.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167
• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-12T01:58:15Z
2024-03-08T15:18:10Z