Title :

High Hydrostatic Pressure Processing of Human Milk Increases Apelin and GLP-1 Contents to Modulate Gut Contraction and Glucose Metabolism in Mice Compared to Holder Pasteurization.

Author(s) :

Wemelle, Eve [Auteur]
Institut de Recherche en Santé Digestive [IRSD]
NeuroMicrobiota
Marousez, Lucie [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
De Lamballerie, Marie [Auteur]
École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique [ONIRIS]
Laboratoire de génie des procédés - environnement - agroalimentaire [GEPEA]
Knauf, Claude [Auteur]
515762|||NeuroMicrobiota (VALID)
Institut de Recherche en Santé Digestive [IRSD]
Lesage, Jean [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Journal title :

Nutrients

Abbreviated title :

Nutrients

Volume number :

14

Pages :

219

Publication date :

2022-01-17

ISSN :

2072-6643

English keyword(s) :

human milk
high hydrostatic pressure
holder pasteurization
GLP-1
apelin
glucose metabolism

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background: High hydrostatic pressure (HHP) processing is a non-thermal method proposed as an alternative to Holder pasteurization (HoP) for the sterilization of human breast milk (BM). HHP preserves numerous milk bioactive ...
Show more >Background: High hydrostatic pressure (HHP) processing is a non-thermal method proposed as an alternative to Holder pasteurization (HoP) for the sterilization of human breast milk (BM). HHP preserves numerous milk bioactive factors that are degraded by HoP, but no data are available for milk apelin and glucagon-like peptide 1 (GLP-1), two hormones implicated in the control of glucose metabolism directly and via the gut–brain axis. This study aims to determine the effects of HoP and HHP processing on apelin and GLP-1 concentrations in BM and to test the effect of oral treatments with HoP- and HHP-BM on intestinal contractions and glucose metabolism in adult mice. Methods: Mice were treated by daily oral gavages with HoP- or HHP-BM during one week before intestinal contractions, and glucose tolerance was assessed. mRNA expression of enteric neuronal enzymes known to control intestinal contraction was measured. Results: HoP-BM displayed a reduced concentration of apelin and GLP-1, whereas HHP processing preserved these hormones close to their initial levels in raw milk. Chronic HHP-BM administration to mice increased ileal mRNA nNos expression level leading to a decrease in gut contraction associated with improved glucose tolerance. Conclusion: In comparison to HoP, HPP processing of BM preserves both apelin and GLP-1 and improves glucose tolerance by acting on gut contractions. This study reinforces previous findings demonstrating that HHP processing provides BM with a higher biological value than BM treated by HoP.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-12T05:12:34Z
2024-03-21T10:31:46Z