Title :

Characterization of theory of mind performance in patients with myotonic dystrophy type 1.

Author(s) :

Davion, Jean Baptiste [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Tard, Celine [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Kuchcinski, Gregory [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Fragoso, Loren [Auteur]
Centre de référence des maladies rares neuromusculaires
Wilu-Wilu, Amina [Auteur]
Maurage, Pierre [Auteur]
Nguyen The Tich, Sylvie [Auteur]
Centre de référence des maladies rares neuromusculaires
Defebvre, Luc [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
D'Hondt, Fabien [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Delbeuck, Xavier [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172

Journal title :

Cortex

Volume number :

168

Pages :

181-192

Publication date :

2023-09-26

ISSN :

1973-8102

Keyword(s) :

Myotonic dystrophy
Neuromuscular disorders
Social cognition
Theory of mind
Movie for the assessment of social cognition

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Introduction Myotonic dystrophy type 1 (DM1) is associated with motor dysfunction as well as psychological and cognitive impairments, including altered social cognition. Theory of mind (ToM) impairments have been reported ...
Show more >Introduction Myotonic dystrophy type 1 (DM1) is associated with motor dysfunction as well as psychological and cognitive impairments, including altered social cognition. Theory of mind (ToM) impairments have been reported in this disease but their nature and their cognitive/cerebral correlates have yet to be determined. Methods Fifty DM1 patients and 50 healthy controls were assessed using the Movie for the Assessment of Social Cognition, which quantifies impairments in affective and cognitive components of ToM through the depiction of everyday situations. We also measured the study participants' cognitive, behavioral and social abilities, quality of life, and brain MRI characteristics. Results DM1 patients presented a significant impairment in ToM performance compared to controls (p < .001). The patients' errors were related to hypomentalizations (p < .001 vs controls) but not to hypermentalizations (p = .95). The affective component was affected (p < .001 vs controls) but not the cognitive component (p = .09). The ToM impairment was associated with demographic variables (older age and a lower educational level), genetic findings (a larger CTG triplets repeat expansion) and cognitive scores (slower information processing speed). Associations were also found with brain MRI variables (lower white matter and supratentorial volumes) but not with behavioral or social variables. Discussion DM1 patients display a ToM impairment, characterized by predominant hypomentalizations concerning the affective component. This impairment might result from structural brain abnormalities observed in DM1.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Submission date :

2024-01-15T22:25:10Z
2024-06-07T08:35:49Z