Prodromal characteristics of dementia with ...
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Article dans une revue scientifique: Article original
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Title :
Prodromal characteristics of dementia with Lewy bodies: baseline results of the MEMENTO memory clinics nationwide cohort.
Author(s) :
Blanc, Jean Frédéric [Auteur]
UOH – Université de Strasbourg [UOH]
Bouteloup, V. [Auteur]
Paquet, C. [Auteur]
Chupin, M. [Auteur]
Pasquier, Florence [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Gabelle, A. [Auteur]
Ceccaldi, M. [Auteur]
De Sousa, P. L. [Auteur]
Krolak-Salmon, P. [Auteur]
David, R. [Auteur]
Fischer, C. [Auteur]
Dartigues, J. F. [Auteur]
Wallon, D. [Auteur]
Moreaud, O. [Auteur]
Sauvée, M. [Auteur]
Belin, C. [Auteur]
Harston, S. [Auteur]
Botzung, A. [Auteur]
Albasser, T. [Auteur]
Demuynck, C. [Auteur]
Namer, I. [Auteur]
Habert, M. O. [Auteur]
Kremer, S. [Auteur]
Bousiges, O. [Auteur]
Verny, M. [Auteur]
Muller, C. [Auteur]
Philippi, N. [Auteur]
Chene, G. [Auteur]
Cretin, B. [Auteur]
Mangin, J. F. [Auteur]
Dufouil, C. [Auteur]
UOH – Université de Strasbourg [UOH]
Bouteloup, V. [Auteur]
Paquet, C. [Auteur]
Chupin, M. [Auteur]
Pasquier, Florence [Auteur]

Lille Neurosciences & Cognition (LilNCog) - U 1172
Gabelle, A. [Auteur]
Ceccaldi, M. [Auteur]
De Sousa, P. L. [Auteur]
Krolak-Salmon, P. [Auteur]
David, R. [Auteur]
Fischer, C. [Auteur]
Dartigues, J. F. [Auteur]
Wallon, D. [Auteur]
Moreaud, O. [Auteur]
Sauvée, M. [Auteur]
Belin, C. [Auteur]
Harston, S. [Auteur]
Botzung, A. [Auteur]
Albasser, T. [Auteur]
Demuynck, C. [Auteur]
Namer, I. [Auteur]
Habert, M. O. [Auteur]
Kremer, S. [Auteur]
Bousiges, O. [Auteur]
Verny, M. [Auteur]
Muller, C. [Auteur]
Philippi, N. [Auteur]
Chene, G. [Auteur]
Cretin, B. [Auteur]
Mangin, J. F. [Auteur]
Dufouil, C. [Auteur]
Journal title :
Alzheimer's Research and Therapy
Volume number :
14
Pages :
96
Publisher :
BMC
Publication date :
2022-07-23
ISSN :
1758-9193
Keyword(s) :
Dementia with Lewy bodies
Prodromal
Mild cognitive impairment
Subjective cognitive impairment
Lewy body disease
Mild neurocognitive impairment
Prodromal
Mild cognitive impairment
Subjective cognitive impairment
Lewy body disease
Mild neurocognitive impairment
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Background
Isolated subjective cognitive impairment (SCI) and mild cognitive impairment (MCI) are the prodromal phases of dementia with Lewy bodies (DLB). MEMENTO is a nationwide study of patients with SCI and MCI with ...
Show more >Background Isolated subjective cognitive impairment (SCI) and mild cognitive impairment (MCI) are the prodromal phases of dementia with Lewy bodies (DLB). MEMENTO is a nationwide study of patients with SCI and MCI with clinic, neuropsychology, biology, and brain imaging data. We aimed to compare SCI and MCI patients with symptoms of prodromal DLB to others in this study at baseline. Methods Participants of the French MEMENTO cohort study were recruited for either SCI or MCI. Among them, 892 were included in the Lewy sub-study, designed to search specifically for symptoms of DLB. Probable prodromal DLB diagnosis (pro-DLB group) was done using a two-criteria cutoff score among the four core clinical features of DLB. This Pro-DLB group was compared to two other groups at baseline: one without any core symptoms (NS group) and the one with one core symptom (1S group). A comprehensive cognitive battery, questionnaires on behavior, neurovegetative and neurosensory symptoms, brain 3D volumetric MRI, CSF, FDG PET, and amyloid PET were done. Results The pro-DLB group comprised 148 patients (16.6%). This group showed more multidomain (59.8%) MCI with slower processing speed and a higher proportion of patients with depression, anxiety, apathy, constipation, rhinorrhea, sicca syndrome, and photophobia, compared to the NS group. The pro-DLB group had isolated lower P-Tau in the CSF (not significant after adjustments for confounders) and on brain MRI widening of sulci including fronto-insular, occipital, and olfactory sulci (FDR corrected), when compared to the NS group. Evolution to dementia was not different between the three groups over a median follow-up of 2.6 years. Conclusions Patients with symptoms of prodromal DLB are cognitively slower, with more behavioral disorders, autonomic symptoms, and photophobia. The occipital, fronto-insular, and olfactory bulb involvement on brain MRI was consistent with symptoms and known neuropathology. The next step will be to study the clinical, biological, and imaging evolution of these patients.Show less >
Show more >Background Isolated subjective cognitive impairment (SCI) and mild cognitive impairment (MCI) are the prodromal phases of dementia with Lewy bodies (DLB). MEMENTO is a nationwide study of patients with SCI and MCI with clinic, neuropsychology, biology, and brain imaging data. We aimed to compare SCI and MCI patients with symptoms of prodromal DLB to others in this study at baseline. Methods Participants of the French MEMENTO cohort study were recruited for either SCI or MCI. Among them, 892 were included in the Lewy sub-study, designed to search specifically for symptoms of DLB. Probable prodromal DLB diagnosis (pro-DLB group) was done using a two-criteria cutoff score among the four core clinical features of DLB. This Pro-DLB group was compared to two other groups at baseline: one without any core symptoms (NS group) and the one with one core symptom (1S group). A comprehensive cognitive battery, questionnaires on behavior, neurovegetative and neurosensory symptoms, brain 3D volumetric MRI, CSF, FDG PET, and amyloid PET were done. Results The pro-DLB group comprised 148 patients (16.6%). This group showed more multidomain (59.8%) MCI with slower processing speed and a higher proportion of patients with depression, anxiety, apathy, constipation, rhinorrhea, sicca syndrome, and photophobia, compared to the NS group. The pro-DLB group had isolated lower P-Tau in the CSF (not significant after adjustments for confounders) and on brain MRI widening of sulci including fronto-insular, occipital, and olfactory sulci (FDR corrected), when compared to the NS group. Evolution to dementia was not different between the three groups over a median follow-up of 2.6 years. Conclusions Patients with symptoms of prodromal DLB are cognitively slower, with more behavioral disorders, autonomic symptoms, and photophobia. The occipital, fronto-insular, and olfactory bulb involvement on brain MRI was consistent with symptoms and known neuropathology. The next step will be to study the clinical, biological, and imaging evolution of these patients.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Collections :
Submission date :
2024-01-16T00:59:46Z
2024-09-25T06:58:49Z
2024-09-25T06:58:49Z
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