Small vessel disease and collaterals in ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Small vessel disease and collaterals in ischemic stroke patients treated with thrombectomy.
Author(s) :
Forestier, G. [Auteur]
CHU Limoges
Agbonon, R. [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Bricout, N. [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Benhassen, W. [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Turc, G. [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Bretzner, Martin [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Pasi, Marco [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Benzakoun, J. [Auteur]
Seners, P. [Auteur]
Personnic, Thomas [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Legrand, L. [Auteur]
Trystram, D. [Auteur]
Rodriguez-Regent, C. [Auteur]
Charidimou, A. [Auteur]
Rost, N. S. [Auteur]
Bracard, S. [Auteur]
Clarençon, F. [Auteur]
Eker, O. F. [Auteur]
Nighoghossian, N. [Auteur]
Cordonnier, Charlotte [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Oppenheim, C. [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Naggara, O. [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Henon, Hilde [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Boulouis, G. [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
CHU Limoges
Agbonon, R. [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Bricout, N. [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Benhassen, W. [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Turc, G. [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Bretzner, Martin [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Pasi, Marco [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Benzakoun, J. [Auteur]
Seners, P. [Auteur]
Personnic, Thomas [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Legrand, L. [Auteur]
Trystram, D. [Auteur]
Rodriguez-Regent, C. [Auteur]
Charidimou, A. [Auteur]
Rost, N. S. [Auteur]
Bracard, S. [Auteur]
Clarençon, F. [Auteur]
Eker, O. F. [Auteur]
Nighoghossian, N. [Auteur]
Cordonnier, Charlotte [Auteur]

Lille Neurosciences & Cognition (LilNCog) - U 1172
Oppenheim, C. [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Naggara, O. [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Henon, Hilde [Auteur]

Lille Neurosciences & Cognition (LilNCog) - U 1172
Boulouis, G. [Auteur]
Institut de psychiatrie et neurosciences de Paris [IPNP - U1266 Inserm]
Journal title :
Journal of Neurology
Abbreviated title :
J Neurol
Volume number :
269
Pages :
4708–4716
Publisher :
Springer Verlag
Publication date :
2022-04-08
ISSN :
1432-1459
Keyword(s) :
Thrombectomy
Stroke
Cerebral small vessel disease
Collateral circulation
Magnetic resonance imaging
Stroke
Cerebral small vessel disease
Collateral circulation
Magnetic resonance imaging
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Background and purpose
To determine the influence of the cerebral small vessel disease (SVD) burden on collateral recruitment in patients treated with mechanical thrombectomy (MT) for anterior circulation acute ischemic ...
Show more >Background and purpose To determine the influence of the cerebral small vessel disease (SVD) burden on collateral recruitment in patients treated with mechanical thrombectomy (MT) for anterior circulation acute ischemic stroke (AIS). Methods Patients with AIS due to large vessel occlusion (LVO) from the Thrombectomie des Artères Cérébrales (THRACE) trial and prospective cohorts from 2 academic comprehensive stroke centers treated with MT were pooled and retrospectively analyzed. Collaterals’ adequacy was assessed using the American Society of Interventional and Therapeutic Radiology/Society of Interventional Radiology (ASITN/SIR) score on initial digital subtraction angiography and dichotomized as good (3,4) versus poor (0–2) collaterals. The SVD burden was rated with the global SVD score on MRI. Multivariable logistic regression analyses were used to determine relationships between SVD and ASITN/SIR scores. Results A total of 312 participants were included (53.2% males, mean age 67.8 ± 14.9 years). Two hundred and seven patients had poor collaterals (66.4%), and 133 (42.6%) presented with any SVD signature. In multivariable analysis, patients demonstrated worse leptomeningeal collaterality with increasing SVD burden before and after adjustment for SVD risk factors (adjusted odds ratio [aOR] 0.69; 95%CI [0.52–0.89] and aOR 0.66; 95%CI [0.5–0.88], respectively). Using individual SVD markers, poor collaterals were significantly associated with the presence of lacunes (aOR 0.40, 95% CI [0.20–0.79]). Conclusion Our study provides evidence that in patients with AIS due to LVO treated with MT, the burden of SVD assessed by pre-treatment MRI is associated with poorer recruitment of leptomeningeal collaterals.Show less >
Show more >Background and purpose To determine the influence of the cerebral small vessel disease (SVD) burden on collateral recruitment in patients treated with mechanical thrombectomy (MT) for anterior circulation acute ischemic stroke (AIS). Methods Patients with AIS due to large vessel occlusion (LVO) from the Thrombectomie des Artères Cérébrales (THRACE) trial and prospective cohorts from 2 academic comprehensive stroke centers treated with MT were pooled and retrospectively analyzed. Collaterals’ adequacy was assessed using the American Society of Interventional and Therapeutic Radiology/Society of Interventional Radiology (ASITN/SIR) score on initial digital subtraction angiography and dichotomized as good (3,4) versus poor (0–2) collaterals. The SVD burden was rated with the global SVD score on MRI. Multivariable logistic regression analyses were used to determine relationships between SVD and ASITN/SIR scores. Results A total of 312 participants were included (53.2% males, mean age 67.8 ± 14.9 years). Two hundred and seven patients had poor collaterals (66.4%), and 133 (42.6%) presented with any SVD signature. In multivariable analysis, patients demonstrated worse leptomeningeal collaterality with increasing SVD burden before and after adjustment for SVD risk factors (adjusted odds ratio [aOR] 0.69; 95%CI [0.52–0.89] and aOR 0.66; 95%CI [0.5–0.88], respectively). Using individual SVD markers, poor collaterals were significantly associated with the presence of lacunes (aOR 0.40, 95% CI [0.20–0.79]). Conclusion Our study provides evidence that in patients with AIS due to LVO treated with MT, the burden of SVD assessed by pre-treatment MRI is associated with poorer recruitment of leptomeningeal collaterals.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Collections :
Submission date :
2024-01-16T01:18:46Z
2024-10-23T09:35:50Z
2024-10-23T09:35:50Z