Title :

Efficacy of traumatic memory reactivation with or without propranolol in PTSD with high dissociative experiences

Author(s) :

Roullet, Pascal [Auteur]
Taib, Simon [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Thalamas, Claire [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Centre d'investigation clinique de Toulouse [CIC 1436]
Vaiva, Guillaume [Auteur]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
El Hage, Wissam [Auteur]
Centre d’Investigation Clinique [Tours] CIC 1415 [CIC]
Université de Tours [UT]
Yrondi, Antoine [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Birmes, Philippe [Auteur]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]

Journal title :

European Journal of Psychotraumatology

Volume number :

13

Publication date :

2022-12-01

ISSN :

2000-8198

Keyword(s) :

PTSD
dissociation
propranolol
memory reactivation
MDE
traumatic memory
depression
High Dissociative Experiences

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background: Post-traumatic stress disorder (PTSD) with dissociative symptoms is now a full-fledged subtype of this disorder. The dissociative subtype is associated with a greater number of psychiatric comorbidities. To ...
Show more >Background: Post-traumatic stress disorder (PTSD) with dissociative symptoms is now a full-fledged subtype of this disorder. The dissociative subtype is associated with a greater number of psychiatric comorbidities. To date, the impact of dissociation on the efficacy of PTSD treatment remains unclear. Objective: The aim of this study was to compare the efficacy of a traumatic memory reactivation procedure with the administration of propranolol or a placebo once a week for six consecutive weeks in reducing PTSD and MDE symptoms between PTSD subjects with or without high dissociative symptoms. Method: For that, we conducted a randomized clinical trial in 66 adults diagnosed with longstanding PTSD and measured the SCID PTSD module, the PTSD Checklist (PCL-S), Beck’s Depression Inventory-II (BDI-II), and the Dissociative Experiences Scale (DES). Results: Patients with and without high dissociative experience had significant improvement in their PCL-S scores over the 6 treatment sessions, and PCL-S scores continued to decline in all patients during the post-treatment period. However, there was no correlation between the presence/absence of high dissociative experiences and no specific effect of propranolol treatment. We found exactly the same results for MDE symptoms. Interestingly, patients with high dissociative experiences before treatment exhibited very significant improvement in their DES scores after the 6 treatment sessions, and patients maintained this improvement 3 months post-treatment. Conclusions: The traumatic memory reactivation procedure is an effective way to treat dissociative symptoms in patients with PTSD, and improvement of these dissociative symptoms was associated with a decrease in both PTSD and depression severity.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193

Submission date :

2024-01-16T02:48:14Z
2025-01-23T14:01:51Z
2025-01-23T14:03:18Z