Title :

Metastatic Potential and Survival of Duodenal and Pancreatic Tumors in Multiple Endocrine Neoplasia Type 1: A GTE and AFCE Cohort Study (Groupe d''étude des Tumeurs Endocrines and Association Francophone de Chirurgie Endocrinienne).

Author(s) :

Vinault, S. [Auteur]
Mariet, A. S. [Auteur]
Le Bras, M. [Auteur]
Mirallié, E. [Auteur]
Cardot-Bauters, C. [Auteur]
Pattou, Francois [Auteur]
Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 [EGID]
Recherche translationnelle sur le diabète (RTD) - U1190
Ruszniewski, P. [Auteur]
Sauvanet, A. [Auteur]
Chanson, P. [Auteur]
Baudin, E. [Auteur]
Elias, D. [Auteur]
Menegaux, F. [Auteur]
Gaujoux, S. [Auteur]
Borson-Chazot, F. [Auteur]
Lifante, J. C. [Auteur]
Caron, P. [Auteur]
Carrère, N. [Auteur]
Tabarin, A. [Auteur]
Laurent, C. [Auteur]
Klein, M. [Auteur]
Brunaud, L. [Auteur]
Niccoli, P. [Auteur]
Sebag, F. [Auteur]
Cadiot, G. [Auteur]
Kianmanesh, R. [Auteur]
Luu, M. [Auteur]
Binquet, C. [Auteur]
Goudet, P. [Auteur]

Journal title :

Annals of Surgery

Abbreviated title :

Ann. Surg.

Volume number :

272

Pages :

p. 1094-1101

Publication date :

2020-12

ISSN :

1528-1140

English keyword(s) :

MEN1
metastases
neuroendocrine tumors
pancreas
survival

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Objective: To assess the distant metastatic potential of duodeno-pancreatic neuroendocrine tumors (DP-NETs) in patients with MEN1, according to functional status and size. Summary Background Data: DP-NETs, with ...
Show more >Objective: To assess the distant metastatic potential of duodeno-pancreatic neuroendocrine tumors (DP-NETs) in patients with MEN1, according to functional status and size. Summary Background Data: DP-NETs, with their numerous lesions and endocrine secretion-related symptoms, continue to be a medical challenge; unfortunately they can become aggressive tumors associated with distant metastasis, shortening survival. The survival of patients with large nonfunctional DP-NETs is known to be poor, but the overall contribution of DP-NETs to metastatic spread is poorly known. Methods: The study population included patients with DP-NETs diagnosed after 1990 and followed in the MEN1 cohort of the Groupe d’étude des Tumeurs Endocrines (GTE). A multistate Markov piecewise constant intensities model was applied to separate the effects of prognostic factors on 1) metastasis, and 2) metastasis-free death or 3) death after appearance of metastases. Results: Among the 603 patients included, 39 had metastasis at diagnosis of DP-NET, 50 developed metastases during follow-up, and 69 died. The Markov model showed that Zollinger-Ellison-related tumors (regardless of tumor size and thymic tumor pejorative impact), large tumors over 2 cm, and age over 40 years were independently associated with an increased risk of metastases. Men, patients over 40 years old and patients with tumors larger than 2 cm, also had an increased risk of death once metastasis appeared. Conclusions: DP-NETs of 2 cm in size or more, regardless of the associated secretion, should be removed to prevent metastasis and increase survival. Surgery for gastrinoma remains debatable.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Recherche translationnelle sur le diabète (RTD) - U1190

Submission date :

2024-01-19T23:55:08Z
2024-10-03T09:10:01Z