Title :

Management of car-t cell-related encephalopathy syndrome in adult and pediatric patients: recommendations of the french society of bone marrow transplantation and cellular therapy (sfgm-tc)

Author(s) :

Cornillon, Jerome [Auteur]
Hadhoum, Nawal [Auteur]
Roth-Guepin, Gabrielle [Auteur]
Quessar, Asmaa [Auteur]
Platon, Lara [Auteur]
Ouachee-Chardin, Marie [Auteur]
Nicolas-Virelizier, Emmanuelle [Auteur]
Naudin, Jerome [Auteur]
Moreau, Anne-Sophie [Auteur]
Masouridi-Levrat, Stavroula [Auteur]
Borel, Cecile [Auteur]
Ahmad, Imran [Auteur]
Beauvais, David [Auteur]
Baruchel, Andre [Auteur]
Yakoub-Agha, Ibrahim [Auteur]

Journal title :

Bulletin du cancer

Abbreviated title :

Bull Cancer

Publication date :

2019-06-12

ISSN :

1769-6917

English keyword(s) :

CRES
CAR-T
Management
Neurologic disorders

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

CAR-T cell-related encephalopathy syndrome (CRES) reflects the potential neurotoxicity of this therapeutic approach and must be considered in the presence of any neurological symptom after the infusion of the CAR-T. This ...
Show more >CAR-T cell-related encephalopathy syndrome (CRES) reflects the potential neurotoxicity of this therapeutic approach and must be considered in the presence of any neurological symptom after the infusion of the CAR-T. This is the second most common adverse event under this therapy and its incidence varies between 12 and 55%. The median time of the onset of the first neurologic symptoms is 4days after CAR-T infusion. The duration of CRES symptoms is generally between 2 and 4days, but late CRES may occur. Monitoring and diagnosis of CERS includes clinical exam, magnetic resonance imaging and electroencephalography. In addition to symptomatic treatments, corticosteroids represent the cornerstone of the high-grade CERS treatment. Drugs targeting IL-6 should be restricted to severe forms, especially those associated with cytokine release syndrome. The purpose of this workshop is to provide practical help in dealing with this complication.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-01-30T10:28:18Z