Title :

Prognosis of impulse control disorders in Parkinson's disease: a prospective controlled study.

Author(s) :

Wirth, Thomas [Auteur]
Goetsch, Thibaut [Auteur]
Corvol, Jean-Christophe [Auteur]
Roze, Emmanuel [Auteur]
Mariani, Louise-Laure [Auteur]
Vidailhet, Marie [Auteur]
Grabli, David [Auteur]
Mallet, Luc [Auteur]
Pelissolo, Antoine [Auteur]
Rascol, Olivier [Auteur]
Brefel-Courbon, Christine [Auteur]
Ory-Magne, Fabienne [Auteur]
Arbus, Christophe [Auteur]
Bekadar, Samir [Auteur]
Krystkowiak, Pierre [Auteur]
Marques, Ana [Auteur]
Llorca, Michel [Auteur]
Krack, Paul [Auteur]
Castrioto, Anna [Auteur]
Fraix, Valérie [Auteur]
Maltete, David [Auteur]
Defebvre, Luc [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Service de neurologie et pathologie du mouvement
Kreisler, Alexandre [Auteur]
Service de neurologie et pathologie du mouvement
Houeto, Jean-Luc [Auteur]
Tranchant, Christine [Auteur]
Meyer, Nicolas [Auteur]
Anheim, Mathieu [Auteur]

Journal title :

Journal of Neurology

Abbreviated title :

J Neurol

Volume number :

271

Pages :

2412–2422

Publication date :

2024-01-12

ISSN :

1432-1459

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background The long-term prognosis of impulsive compulsive disorders (ICD) remains poorly studied in Parkinson’s disease (PD). Objective Evaluating the natural history of ICD and its impact on PD symptoms including ...
Show more >Background The long-term prognosis of impulsive compulsive disorders (ICD) remains poorly studied in Parkinson’s disease (PD). Objective Evaluating the natural history of ICD and its impact on PD symptoms including cognition and treatment adjustments. Materials and methods We assessed PD patients at baseline (BL) with (BL-ICD+) or without (BL-ICD-) ICD despite dopamine agonist (DA) exposure of > 300 mg levodopa-equivalent daily dose for > 12 months at baseline and after more than two years of follow-up. ICD were assessed using the Ardouin’s Scale of Behaviors in PD (ASBPD), cognition using the Mattis scale, and PD symptoms using the UPDRS score. Treatment adjustments, DA withdrawal-associated symptoms, and ICDs social consequences were recorded. Results 149 patients were included (78 cases and 71 controls), mean duration of follow-up was 4.4 ± 1 years. At baseline, psychiatric disorders were more common among BL-ICD + (42.3 vs 12.3% among BL-ICD-, p < 0.01). At follow-up, 53.8% of BL-ICD + were not ICD-free while 21.1% of BL-ICD- had developed ICD. BL-ICD + more frequently experienced akinesia (21.8 vs 8.5%, p = 0.043) and rigidity worsening (11.5 vs 1.4%, p = 0.019) following therapeutic modifications. Decision to decrease > 50% DA doses (12.8 vs 1.4%, p = 0.019) or to withdraw DA (19.2 vs 5.6%, p = 0.025) was more frequently considered among BL-ICD+ . At follow-up, the prevalence of cognitive decline was lower among BL-ICD + (19.2 vs 37.1%, p = 0.025). Conclusion ICDs were associated with increased psychiatric burden at baseline and better cognitive prognosis. Most patients were still showing ICDs at the follow-up visit, suggesting ICD to be considered as a chronic, neuropsychiatric disorder.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Submission date :

2024-02-06T23:13:18Z
2025-02-19T13:05:39Z