Title :

Identification of a miRNA multi-targeting therapeutic strategy in glioblastoma.

Author(s) :

Bassot, Arthur [Auteur]
Centre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
Dragic, Helena [Auteur]
Centre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
Haddad, Sarah Al [Auteur]
Geneva University Hospitals and Geneva University
Moindrot, Laurine [Auteur]
Geneva University Hospitals and Geneva University
Centre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
Odouard, Soline [Auteur]
Geneva University Hospitals and Geneva University
Corlazzoli, Francesca [Auteur]
Geneva University Hospitals and Geneva University
Marinari, Eliana [Auteur]
Geneva University Hospitals and Geneva University
Bomane, Alexandra [Auteur]
Centre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
Brassens, Augustin [Auteur]
Centre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
Marteyn, Antoine [Auteur]
Geneva University Hospitals and Geneva University
Hibaoui, Youssef [Auteur]
Fribourg Cantonal Hospital
Petty, Tom J. [Auteur]
Swiss Institute of Bioinformatics [Genève] [SIB]
Chalabi-Dchar, Mounira [Auteur]
Centre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
Larrouquere, Louis [Auteur]
Centre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
Zdobnov, Evgeny M. [Auteur]
Swiss Institute of Bioinformatics [Genève] [SIB]
Legrand, Noemie [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Geneva University Hospitals and Geneva University
Tamburini, Jérôme [Auteur]
Geneva University Hospitals and Geneva University
Lincet, Hubert [Auteur]
Centre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
Castets, Marie [Auteur]
Centre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
Yebra, Mayra [Auteur]
Moores Cancer Center [La Jolla]
Migliorini, Denis [Auteur]
Geneva University Hospitals and Geneva University
Dutoit, Valérie [Auteur]
Geneva University Hospitals and Geneva University
Walker, Paul R. [Auteur]
Geneva University Hospitals and Geneva University
Preynat-Seauve, Olivier [Auteur]
Geneva University Hospitals and Geneva University
Dietrich, Pierre-Yves [Auteur]
Geneva University Hospitals and Geneva University
Cosset, Érika [Auteur]
Geneva University Hospitals and Geneva University
Centre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]

Journal title :

Cell Death and Disease

Abbreviated title :

Cell Death Dis

Volume number :

14

Pages :

630

Publication date :

2023-10-04

ISSN :

2041-4889

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Glioblastoma (GBM) is a deadly and the most common primary brain tumor in adults. Due to their regulation of a high number of mRNA transcripts, microRNAs (miRNAs) are key molecules in the control of biological processes ...
Show more >Glioblastoma (GBM) is a deadly and the most common primary brain tumor in adults. Due to their regulation of a high number of mRNA transcripts, microRNAs (miRNAs) are key molecules in the control of biological processes and are thereby promising therapeutic targets for GBM patients. In this regard, we recently reported miRNAs as strong modulators of GBM aggressiveness. Here, using an integrative and comprehensive analysis of the TCGA database and the transcriptome of GBM biopsies, we identified three critical and clinically relevant miRNAs for GBM, miR-17-3p, miR-222, and miR-340. In addition, we showed that the combinatorial modulation of three of these miRNAs efficiently inhibited several biological processes in patient-derived GBM cells of all these three GBM subtypes (Mesenchymal, Proneural, Classical), induced cell death, and delayed tumor growth in a mouse tumor model. Finally, in a doxycycline-inducible model, we observed a significant inhibition of GBM stem cell viability and a significant delay of orthotopic tumor growth. Collectively, our results reveal, for the first time, the potential of miR-17-3p, miR-222 and miR-340 multi-targeting as a promising therapeutic strategy for GBM patients.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-02-09T22:20:19Z
2024-03-22T10:38:56Z