Tips and Tricks and Clinical Outcome of ...
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Title :
Tips and Tricks and Clinical Outcome of Cryopreserved Human Amniotic Membrane Application for the Management of Medication-Related Osteonecrosis of the Jaw (MRONJ): A Pilot Study
Author(s) :
Odet, Stéphane [Auteur]
Service de Chirurgie Maxillo-Faciale et Stomatologie
Meyer, Christophe [Auteur]
Nanomédecine, imagerie, thérapeutique - UFC (UR 4662) [NIT / NANOMEDECINE]
Service de Chirurgie Maxillo-Faciale et Stomatologie
Gaudet, Camille [Auteur]
Service de Chirurgie Maxillo-Faciale et Stomatologie
Weber, Elise [Auteur]
Service de Chirurgie Maxillo-Faciale et Stomatologie
Quenot, Julie [Auteur]
Service de Chirurgie Maxillo-Faciale et Stomatologie
Derruau, Stéphane [Auteur]
Biospectroscopie Translationnelle - EA 7506 [BIOSPECT]
Laurence, Sebastien [Auteur]
Hémostase et Remodelage Vasculaire Post-Ischémie [HERVI - EA 3801]
Bompy, Lisa [Auteur]
Service Chirurgie Maxillo-Faciale - Stomatologie - Chirurgie Plastique Réparatrice et Esthétique - Chirurgie de la main (CHU de Dijon)
Girodon, Marine [Auteur]
Service Chirurgie Maxillo-Faciale - Stomatologie - Chirurgie Plastique Réparatrice et Esthétique - Chirurgie de la main (CHU de Dijon)
Chatelain, Brice [Auteur]
Service de Chirurgie Maxillo-Faciale et Stomatologie
Mauprivez, Cédric [Auteur]
Biomatériaux et inflammation en site osseux - EA 4691 [BIOS]
Brenet, Esteban [Auteur]
Kerdjoudj, Halima [Auteur]
Biomatériaux et inflammation en site osseux - EA 4691 [BIOS]
Zwetyenga, Narcisse [Auteur]
Service Chirurgie Maxillo-Faciale - Stomatologie - Chirurgie Plastique Réparatrice et Esthétique - Chirurgie de la main (CHU de Dijon)
Marchetti, Philippe [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Hatzfeld, Anne-Sophie [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Toubeau, David [Auteur]
Pouthier, Fabienne [Auteur]
Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) [RIGHT]
Lafarge, Xavier [Auteur]
Biothérapies des maladies génétiques et cancers
Redl, Heinz [Auteur]
Fenelon, Mathilde [Auteur]
Bioingénierie tissulaire [BIOTIS]
Fricain, Jean-Christophe [Auteur]
Bioingénierie tissulaire [BIOTIS]
Di Pietro, Roberta [Auteur]
Ledouble, Charlotte [Auteur]
Biomatériaux et inflammation en site osseux - EA 4691 [BIOS]
Gualdi, Thomas [Auteur]
Centre d'Investigation Clinique de Besançon [Inserm CIC 1431]
Parmentier, Anne-Laure [Auteur]
Centre d'Investigation Clinique de Besançon [Inserm CIC 1431]
Louvrier, Aurélien [Auteur]
Service de Chirurgie Maxillo-Faciale et Stomatologie
Gindraux, Florelle [Auteur correspondant]
Service de Chirurgie Maxillo-Faciale et Stomatologie
Nanomédecine, imagerie, thérapeutique - UFC (UR 4662) [NIT / NANOMEDECINE]
Service de Chirurgie Maxillo-Faciale et Stomatologie
Meyer, Christophe [Auteur]
Nanomédecine, imagerie, thérapeutique - UFC (UR 4662) [NIT / NANOMEDECINE]
Service de Chirurgie Maxillo-Faciale et Stomatologie
Gaudet, Camille [Auteur]
Service de Chirurgie Maxillo-Faciale et Stomatologie
Weber, Elise [Auteur]
Service de Chirurgie Maxillo-Faciale et Stomatologie
Quenot, Julie [Auteur]
Service de Chirurgie Maxillo-Faciale et Stomatologie
Derruau, Stéphane [Auteur]
Biospectroscopie Translationnelle - EA 7506 [BIOSPECT]
Laurence, Sebastien [Auteur]
Hémostase et Remodelage Vasculaire Post-Ischémie [HERVI - EA 3801]
Bompy, Lisa [Auteur]
Service Chirurgie Maxillo-Faciale - Stomatologie - Chirurgie Plastique Réparatrice et Esthétique - Chirurgie de la main (CHU de Dijon)
Girodon, Marine [Auteur]
Service Chirurgie Maxillo-Faciale - Stomatologie - Chirurgie Plastique Réparatrice et Esthétique - Chirurgie de la main (CHU de Dijon)
Chatelain, Brice [Auteur]
Service de Chirurgie Maxillo-Faciale et Stomatologie
Mauprivez, Cédric [Auteur]
Biomatériaux et inflammation en site osseux - EA 4691 [BIOS]
Brenet, Esteban [Auteur]
Kerdjoudj, Halima [Auteur]
Biomatériaux et inflammation en site osseux - EA 4691 [BIOS]
Zwetyenga, Narcisse [Auteur]
Service Chirurgie Maxillo-Faciale - Stomatologie - Chirurgie Plastique Réparatrice et Esthétique - Chirurgie de la main (CHU de Dijon)
Marchetti, Philippe [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Hatzfeld, Anne-Sophie [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Toubeau, David [Auteur]
Pouthier, Fabienne [Auteur]
Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) [RIGHT]
Lafarge, Xavier [Auteur]
Biothérapies des maladies génétiques et cancers
Redl, Heinz [Auteur]
Fenelon, Mathilde [Auteur]
Bioingénierie tissulaire [BIOTIS]
Fricain, Jean-Christophe [Auteur]
Bioingénierie tissulaire [BIOTIS]
Di Pietro, Roberta [Auteur]
Ledouble, Charlotte [Auteur]
Biomatériaux et inflammation en site osseux - EA 4691 [BIOS]
Gualdi, Thomas [Auteur]
Centre d'Investigation Clinique de Besançon [Inserm CIC 1431]
Parmentier, Anne-Laure [Auteur]
Centre d'Investigation Clinique de Besançon [Inserm CIC 1431]
Louvrier, Aurélien [Auteur]
Service de Chirurgie Maxillo-Faciale et Stomatologie
Gindraux, Florelle [Auteur correspondant]
Service de Chirurgie Maxillo-Faciale et Stomatologie
Nanomédecine, imagerie, thérapeutique - UFC (UR 4662) [NIT / NANOMEDECINE]
Journal title :
Frontiers in Bioengineering and Biotechnology
Pages :
936074
Publisher :
Frontiers
Publication date :
2022
ISSN :
2296-4185
English keyword(s) :
human amniotic membrane
osteonecrosis
oral mucosa
allograft
bisphosphonates
denosumab
antiangiogenic drugs
osteonecrosis
oral mucosa
allograft
bisphosphonates
denosumab
antiangiogenic drugs
HAL domain(s) :
Sciences du Vivant [q-bio]/Ingénierie biomédicale/Biomatériaux
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Chirurgie
Sciences du Vivant [q-bio]/Cancer
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Chirurgie
Sciences du Vivant [q-bio]/Cancer
English abstract : [en]
Medication-related osteonecrosis of the jaw (MRONJ) is a complication of certain pharmacological treatments such as bisphosphonates, denosumab, and angiogenesis inhibitors. There are currently no guidelines on its management, ...
Show more >Medication-related osteonecrosis of the jaw (MRONJ) is a complication of certain pharmacological treatments such as bisphosphonates, denosumab, and angiogenesis inhibitors. There are currently no guidelines on its management, particularly in advanced stages. The human amniotic membrane (hAM) has low immunogenicity and exerts anti-inflammatory, antifibrotic, antimicrobial, antiviral, and analgesic effects. It is a source of stem cells and growth factors promoting tissue regeneration. hAM acts as an anatomical barrier with suitable mechanical properties (permeability, stability, elasticity, flexibility, and resorbability) to prevent the proliferation of fibrous tissue and promote early neovascularization at the surgical site. In oral surgery, hAM stimulates healing and facilitates the proliferation and differentiation of epithelial cells in the oral mucosa and therefore its regeneration. We proposed using cryopreserved hAM to eight patients suffering from cancer (11 lesions) with stage 2–3 MRONJ on a compassionate use basis. A collagen sponge was added in some cases to facilitate hAM grafting. One or three hAMs were applied and one patient had a reapplication. Three patients had complete closure of the surgical site with proper epithelialization at 2 weeks, and two of them maintained it until the last follow-up. At 1 week after surgery, three patients had partial wound dehiscence with partial healing 3 months later and two patients had complete wound dehiscence. hAM reapplication led to complete healing. All patients remained asymptomatic with excellent immediate significant pain relief, no infections, and a truly positive impact on the patients’ quality of life. No adverse events occurred. At 6 months of follow-up, 80% of lesions had complete or partial wound healing (30 and 50%, respectively), while 62.5% of patients were in stage 3. Radiological evaluations found that 85.7% of patients had stable bone lesions ( n = 5) or new bone formation ( n = 1). One patient had a worsening MRONJ but remained asymptomatic. One patient did not attend his follow-up radiological examination. For the first time, this prospective pilot study extensively illustrates both the handling and surgical application of hAM in MRONJ, its possible association with a collagen sponge scaffold, its outcome at the site, the application of multiple hAM patches at the same time, and its reapplication.Show less >
Show more >Medication-related osteonecrosis of the jaw (MRONJ) is a complication of certain pharmacological treatments such as bisphosphonates, denosumab, and angiogenesis inhibitors. There are currently no guidelines on its management, particularly in advanced stages. The human amniotic membrane (hAM) has low immunogenicity and exerts anti-inflammatory, antifibrotic, antimicrobial, antiviral, and analgesic effects. It is a source of stem cells and growth factors promoting tissue regeneration. hAM acts as an anatomical barrier with suitable mechanical properties (permeability, stability, elasticity, flexibility, and resorbability) to prevent the proliferation of fibrous tissue and promote early neovascularization at the surgical site. In oral surgery, hAM stimulates healing and facilitates the proliferation and differentiation of epithelial cells in the oral mucosa and therefore its regeneration. We proposed using cryopreserved hAM to eight patients suffering from cancer (11 lesions) with stage 2–3 MRONJ on a compassionate use basis. A collagen sponge was added in some cases to facilitate hAM grafting. One or three hAMs were applied and one patient had a reapplication. Three patients had complete closure of the surgical site with proper epithelialization at 2 weeks, and two of them maintained it until the last follow-up. At 1 week after surgery, three patients had partial wound dehiscence with partial healing 3 months later and two patients had complete wound dehiscence. hAM reapplication led to complete healing. All patients remained asymptomatic with excellent immediate significant pain relief, no infections, and a truly positive impact on the patients’ quality of life. No adverse events occurred. At 6 months of follow-up, 80% of lesions had complete or partial wound healing (30 and 50%, respectively), while 62.5% of patients were in stage 3. Radiological evaluations found that 85.7% of patients had stable bone lesions ( n = 5) or new bone formation ( n = 1). One patient had a worsening MRONJ but remained asymptomatic. One patient did not attend his follow-up radiological examination. For the first time, this prospective pilot study extensively illustrates both the handling and surgical application of hAM in MRONJ, its possible association with a collagen sponge scaffold, its outcome at the site, the application of multiple hAM patches at the same time, and its reapplication.Show less >
Language :
Anglais
Popular science :
Non
Source :
Submission date :
2024-02-17T03:52:01Z
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