Title :

Engineering microscale biomimetic hydroscaffold for dynamic three-dimensional modeling of pancreatic cancer

Author(s) :

Miollis, Frederick De [Auteur]
Laboratory for Integrated Micro Mechatronics Systems [LIMMS]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Bio-Micro-Electro-Mechanical Systems - IEMN [BIOMEMS - IEMN]
Souguir, Zied [Auteur]
Poiraud, Charles [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
de Saxce, Joseph [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Dercourt, Lucie [Auteur]
Laboratory for Integrated Micro Mechatronics Systems [LIMMS]
Vandenhaute, Elodie [Auteur]
Vincent, Audrey [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Maubon, Nathalie [Auteur]
Van Seuningen, Isabelle [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Senez, Vincent [Auteur]
Laboratory for Integrated Micro Mechatronics Systems [LIMMS]

Conference title :

2021 IEEE 34th International Conference on Micro Electro Mechanical Systems (MEMS)

City :

Gainesville

Country :

Etats-Unis d'Amérique

Start date of the conference :

2021-01-25

Journal title :

Proceedings of the IEEE 34th International Conference on Micro Electro Mechanical Systems, MEMS 2021

Publisher :

IEEE

English keyword(s) :

BIOMIMESYS
tumor microenvironment
FOLFIRINOX
hyaluronan hydroscaffold
organ-on-a-chip
Pancreatic cancer

HAL domain(s) :

Sciences de l'ingénieur [physics]

English abstract : [en]

Pancreatic cancer (PC) is a deadly cancer for which no diagnostic or prevention plan currently exists since this cancer is asymptomatic in its early development. The very specific and complex tumor microenvironment of PC ...
Show more >Pancreatic cancer (PC) is a deadly cancer for which no diagnostic or prevention plan currently exists since this cancer is asymptomatic in its early development. The very specific and complex tumor microenvironment of PC is responsible for the unsuccessful delivery of therapeutics molecules to tumor cells. For high throughput testing of new molecules, there is a crucial need for more accurate preclinical model. For the first time, we integrated in a microfluidic system 5 major features of PC microenvironment: i) type-I collagen (CI), ii) hyaluronic acid (HA), iii) pancreatic stellate cells (SC), iv) interstitial fluid flow and v) nutrient and oxygen gradients. We showed long 3D culture (30 days). Furthermore, we implemented, thanks to the perfusion capability, the actual FOLFIRINOX protocol to assess the IC50 and we showed that dynamic conditions induce increased chemoresistance compared to 3D static.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL

Submission date :

2024-02-17T04:14:27Z