A role for GnRH in olfaction and cognition: ...
Document type :
Article dans une revue scientifique: Article de synthèse/Review paper
DOI :
PMID :
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Title :
A role for GnRH in olfaction and cognition: implications for veterinary medicine.
Author(s) :
Prevot, Vincent [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Duittoz, A. [Auteur]
Université de Tours [UT]
Duittoz, Anne [Auteur]

Lille Neurosciences & Cognition (LilNCog) - U 1172
Duittoz, A. [Auteur]
Université de Tours [UT]
Duittoz, Anne [Auteur]
Journal title :
Reproduction in Domestic Animals
Abbreviated title :
Reprod Domest Anim
Volume number :
58
Pages :
109-124
Publisher :
Wiley
Publication date :
2023-06-18
ISSN :
1439-0531
English keyword(s) :
well-aging
smell
reproduction
neurodevelopmental diseases
learning
hypothalamus
brain
smell
reproduction
neurodevelopmental diseases
learning
hypothalamus
brain
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Pulsatile secretion of gonadotropin-releasing hormone (GnRH) is essential for the activation and maintenance of the function of the hypothalamic–pituitary-gonadal (HPG) axis, which controls the onset of puberty and fertility. ...
Show more >Pulsatile secretion of gonadotropin-releasing hormone (GnRH) is essential for the activation and maintenance of the function of the hypothalamic–pituitary-gonadal (HPG) axis, which controls the onset of puberty and fertility. Two provocative recent studies suggest that, in addition to control reproduction, the neurons in the brain that produce GnRH are also involved in the control postnatal brain maturation, odour discrimination and adult cognition. Long-acting GnRH antagonists and agonists are commonly used to control fertility and behaviour in veterinary medicine, primarily in males. This review puts into perspective the potential risks of these androgen deprivation therapies and immunization on olfactory and cognitive performances and well-aging in domestic animals, including pets. We will also discuss the results reporting beneficial effects of pharmacological interventions restoring physiological GnRH levels on olfactory and cognitive alterations in preclinical models of Alzheimer's disease, which shares many pathophysiological and behavioural hallmarks with canine cognitive dysfunction. These novel findings raise the intriguing possibility that pulsatile GnRH therapy holds therapeutic potential for the management of this behavioural syndrome affecting older dogs.Show less >
Show more >Pulsatile secretion of gonadotropin-releasing hormone (GnRH) is essential for the activation and maintenance of the function of the hypothalamic–pituitary-gonadal (HPG) axis, which controls the onset of puberty and fertility. Two provocative recent studies suggest that, in addition to control reproduction, the neurons in the brain that produce GnRH are also involved in the control postnatal brain maturation, odour discrimination and adult cognition. Long-acting GnRH antagonists and agonists are commonly used to control fertility and behaviour in veterinary medicine, primarily in males. This review puts into perspective the potential risks of these androgen deprivation therapies and immunization on olfactory and cognitive performances and well-aging in domestic animals, including pets. We will also discuss the results reporting beneficial effects of pharmacological interventions restoring physiological GnRH levels on olfactory and cognitive alterations in preclinical models of Alzheimer's disease, which shares many pathophysiological and behavioural hallmarks with canine cognitive dysfunction. These novel findings raise the intriguing possibility that pulsatile GnRH therapy holds therapeutic potential for the management of this behavioural syndrome affecting older dogs.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
Inserm
CHU Lille
Inserm
CHU Lille
Collections :
Submission date :
2024-02-17T22:12:11Z
2024-10-16T08:00:27Z
2024-10-16T08:00:27Z
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