Title :

Unraveling the compromised biomechanical performance of type 2 diabetes-and Rouxen-Y gastric bypass bone by linking mechanical-structural and physico-chemical properties

Author(s) :

Marin, Carlos [Auteur]
Catholic University of Leuven = Katholieke Universiteit Leuven [KU Leuven]
Papantonakis, Georgios [Auteur]
Catholic University of Leuven = Katholieke Universiteit Leuven [KU Leuven]
Sels, Kathleen [Auteur]
Catholic University of Leuven = Katholieke Universiteit Leuven [KU Leuven]
van Lenthe, G. Harry [Auteur]
Catholic University of Leuven = Katholieke Universiteit Leuven [KU Leuven]
Falgayrac, Guillaume [Auteur]
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]
Vangoitsenhoven, Roman [Auteur]
Catholic University of Leuven = Katholieke Universiteit Leuven [KU Leuven]
van der Schueren, Bart [Auteur]
Catholic University of Leuven = Katholieke Universiteit Leuven [KU Leuven]
Penel, Guillaume [Auteur]
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]
Luyten, Frank [Auteur]
Catholic University of Leuven = Katholieke Universiteit Leuven [KU Leuven]
Vandamme, Katleen [Auteur]
Catholic University of Leuven = Katholieke Universiteit Leuven [KU Leuven]
Kerckhofs, Greet [Auteur]
Catholic University of Leuven = Katholieke Universiteit Leuven [KU Leuven]

Journal title :

Scientific Reports

Pages :

5881

Publisher :

Nature Publishing Group

Publication date :

2018

ISSN :

2045-2322

HAL domain(s) :

Sciences de l'ingénieur [physics]/Mécanique [physics.med-ph]/Biomécanique [physics.med-ph]
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Endocrinologie et métabolisme

English abstract : [en]

Type 2 diabetes mellitus (T2DM) is a metabolic disorder associated with obesity and hyperglycemia. Roux-en-Y gastric bypass (RYGB) surgery is a common treatment for severely obese patients and T2DM. Both RYGB and T2DM are ...
Show more >Type 2 diabetes mellitus (T2DM) is a metabolic disorder associated with obesity and hyperglycemia. Roux-en-Y gastric bypass (RYGB) surgery is a common treatment for severely obese patients and T2DM. Both RYGB and T2DM are linked to increased skeletal fragility, though the exact mechanisms are poorly understood. Our aim was to characterize the structural, mechanical and compositional properties of bones from diet-induced obese and RYGB-treated obese (bypass) mice to elucidate which the exact factors are contributing to the increased skeletal fragility. To achieve this, a combinatory approach including microfocus X-ray computed tomography, 3-point bending, finite element modeling and Raman spectroscopy, was used. Compared to aged-matched lean controls, the obese mice displayed decreased cortical thickness, trabecular bone loss, decreased stiffness and increased Young’s modulus. For the bypass mice, these alterations were even more pronounced, and additionally they showed low mineral-to-matrix ratio in the cortical endosteal area. Accumulation of the advanced glycation end-product (AGE) pentosidine was found in the cortex of obese and bypass groups and this accumulation was correlated with an increased Young’s modulus. In conclusion, we found that the increased fracture risk in T2DM- and post-RYGB bones is mainly driven by accumulation of AGEs and macro-structural alterations, generating biomechanical dysfunctionality.Show less >

Language :

Anglais

Popular science :

Non

Collections :

• Marrow Adiposity & Bone Lab (MABLab) - ULR 4490

Source :

Harvested from HAL