The Two-Way Relationship Between Calcium and Metabolism in Cancer

Dejos, Camille; Gkika, Dimitra; Cantelmo, Anna Rita

Document type :

Compte-rendu et recension critique d'ouvrage

DOI :

10.3389/fcell.2020.573747

Title :

The Two-Way Relationship Between Calcium and Metabolism in Cancer

Author(s) :

Dejos, Camille [Auteur]
Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]
Université de Lille
Gkika, Dimitra [Auteur]

Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Université de Lille
Cantelmo, Anna Rita [Auteur]

Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]
Université de Lille

Journal title :

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

Pages :

573747

Publisher :

Frontiers media

Publication date :

2020-11-13

ISSN :

2296-634X

English keyword(s) :

calcium
signaling
metabolism
interplay
cancer

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Calcium ion (Ca2+) signaling is critical to many physiological processes, and its kinetics and subcellular localization are tightly regulated in all cell types. All Ca2+ flux perturbations impact cell function and may ...
Show more >Calcium ion (Ca2+) signaling is critical to many physiological processes, and its kinetics and subcellular localization are tightly regulated in all cell types. All Ca2+ flux perturbations impact cell function and may contribute to various diseases, including cancer. Several modulators of Ca2+ signaling are attractive pharmacological targets due to their accessibility at the plasma membrane. Despite this, the number of specific inhibitors is still limited, and to date there are no anticancer drugs in the clinic that target Ca2+ signaling. Ca2+ dynamics are impacted, in part, by modifications of cellular metabolic pathways. Conversely, it is well established that Ca2+ regulates cellular bioenergetics by allosterically activating key metabolic enzymes and metabolite shuttles or indirectly by modulating signaling cascades. A coordinated interplay between Ca2+ and metabolism is essential in maintaining cellular homeostasis. In this review, we provide a snapshot of the reciprocal interaction between Ca2+ and metabolism and discuss the potential consequences of this interplay in cancer cells. We highlight the contribution of Ca2+ to the metabolic reprogramming observed in cancer. We also describe how the metabolic adaptation of cancer cells influences this crosstalk to regulate protumorigenic signaling pathways. We suggest that the dual targeting of these processes might provide unprecedented opportunities for anticancer strategies. Interestingly, promising evidence for the synergistic effects of antimetabolites and Ca2+-modulating agents is emerging.Show less >

Language :

Anglais

Popular science :

Non

ANR Project :

ULNE

Collections :

Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL

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