Title :

Safety of Islet Autotransplantation After Pancreatectomy for Adenocarcinoma

Author(s) :

Renaud, Florence [Auteur]
Pôle de Biologie Pathologie Génétique [CHU Lille]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Chetboun, Mikael [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Thevenet, Julien [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Delalleau, Nathalie [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Gmyr, Valery [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Hubert, Thomas [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Bonner, Caroline [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Messager, Mathieu [Auteur]
L'Antique, le Moderne [l'AMO]
Leteurtre, Emmanuelle [Auteur]
Inserm UMR837 Team 5
Mariette, Christophe [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Kerr-Conte, Julie [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Piessen, Guillaume [Auteur]
Hôpital Claude Huriez [Lille]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Pattou, François [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]

Journal title :

Transplantation

Pages :

177-181

Publisher :

Lippincott, Williams & Wilkins

Publication date :

2019-01

ISSN :

0041-1337

HAL domain(s) :

Sciences du Vivant [q-bio]/Cancer

English abstract : [en]

Background Total pancreatectomy with intraportal islet autotransplantation (TPIAT) rather than partial pancreatectomy could represent a major shift in the management of patients with resectable pancreatic ductal adenocarcinoma ...
Show more >Background Total pancreatectomy with intraportal islet autotransplantation (TPIAT) rather than partial pancreatectomy could represent a major shift in the management of patients with resectable pancreatic ductal adenocarcinoma (PDAC) when risks of postoperative pancreatic fistula are well identified. This approach provides a theoretical risk of tumor cell dissemination when islet cells are transplanted into the portal vein. Our objective was to explore the safety of TPIAT in PDAC in a mouse preclinical model of subcutaneous xenotransplantation of human cells isolated from pancreatic specimen during partial pancreatectomy performed for PDAC. Methods Patients requiring pancreatectomy for PDAC were prospectively included. Immunocompromised mice were transplanted with pancreatic cells isolated from the nonmalignant part of the surgical specimen (experimental group). Results were compared with pancreatic tumor implants (control group). Pancreatic grafts were explanted at 6 weeks for histological analyses. Results Nine patients were included, and 31 mice were transplanted. In the experimental group, explants were microscopically devoid of tumor cell, and no metastasis was observed. In the control group, all explants were composed of tumor. Conclusions We report in a preclinical model the absence of local and distant spreading of malignant cells after pancreatic islets xenograft isolated from PDAC patients. These data supports the oncological safety of TPIAT as valuable alternative to partial pancreatectomy for PDAC patients with a high risk of postoperative pancreatic fistula.Show less >

Language :

Anglais

Popular science :

Non

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL