Title :

Is it safe to perform an anastomosis for rectal cancer after prostate cancer? A multicentre study of 126 patients from the GRECCAR group

Author(s) :

Lakkis, Zaher [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Doussot, Alexandre [Auteur]
Service de Chirurgie Digestive [CHRU Besançon]
Manfredelli, Simone [Auteur]
Vernerey, Dewi [Auteur]
Pôle cancérologie (CHRU Besançon)
Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) [RIGHT]
Meillat, Hélène [Auteur]
Institut Paoli-Calmettes [IPC]
Ouaissi, Mehdi [Auteur]
CHU Trousseau [Tours]
Cotte, Eddy [Auteur]
Hospices Civils de Lyon [HCL]
Faucheron, Jean‐luc [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 [TIMC ]
Piessen, Guillaume [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Tuech, Jean‐jacques [Auteur]
Service de Chirurgie Digestive [CHU Rouen]
Lefevre, Jérémie [Auteur]
CHU Saint-Antoine [AP-HP]
Panis, Yves [Auteur]
Beyer, Laura [Auteur]
Hôpital Nord [CHU - APHM]
Brouquet, Antoine [Auteur]
Maladies et hormones du système nerveux [DHNS]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Dumont, Frédéric [Auteur]
Université de Lille
Meurisse, Aurélia [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Rullier, Eric [Auteur]
The French Research Group of Rectal Cancer Surgery = Groupe de Recherche en Chirurgie du Rectum [GRECCAR]
Hôpital Haut-Lévêque [CHU Bordeaux]
Heyd, Bruno [Auteur]
Service de Chirurgie Digestive [CHRU Besançon]

Journal title :

Colorectal Disease

Pages :

594-600

Publisher :

Wiley

Publication date :

2022-01-28

ISSN :

1462-8910

HAL domain(s) :

Sciences du Vivant [q-bio]/Cancer

English abstract : [en]

Abstract Aim To determine the safety of performing an anastomosis after rectal cancer (RC) resection in patients with a previously treated prostate cancer (PC). Methods Patients with a previously treated PC who underwent ...
Show more >Abstract Aim To determine the safety of performing an anastomosis after rectal cancer (RC) resection in patients with a previously treated prostate cancer (PC). Methods Patients with a previously treated PC who underwent rectal resection from 2008 to 2018 were retrospectively included. Outcomes were compared between patients who underwent rectal resection with anastomosis (restorative surgery, RS+ group) and those with a definitive stoma (RS− group). In the RS+ group, anastomotic leak (AL) rates were assessed according to the type of reconstruction. Results A total of 126 patients underwent rectal surgery for mid‐low RC after a previous PC treated by radiotherapy (RT) and/or radical prostatectomy. Overall, 80 patients (63%) underwent a RS and 46 patients (37%) underwent rectal surgery with a definitive stoma. There was no statistical difference between the two groups in terms of intraoperative data, except for the type of resection with more multivisceral resection in the RS‐ group ( p < 0.01). In the RS+group, a diverting stoma was performed in 74% of cases. No difference between the two groups in terms of overall morbidity was found. In the RS+group ( n = 80), 17 patients (21%) experienced AL. Of these, none was observed when delayed coloanal anastomosis was performed ( p = 0.16). Long‐term permanent stoma in the RS+ group was 16% ( n = 13). Conclusion Restorative surgery after resection for RC in patients with a previous history of RT and/or radical prostatectomy for PC is safe without additional morbidity. In selected patients for restorative surgery, performing delayed coloanal anastomosis may represent a promising option.Show less >

Language :

Anglais

Popular science :

Non

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL