Title :

Textbook Oncological Outcome in European GASTRODATA

Author(s) :

Sędłak, Katarzyna [Auteur]
Rawicz-Pruszyński, Karol [Auteur]
Mlak, Radosław [Auteur]
van Sandick, Johanna [Auteur]
Gisbertz, Suzanne [Auteur]
Pera, Manuel [Auteur]
Dal Cero, Mariagiulia [Auteur]
Baiocchi, Gian Luca [Auteur]
Università degli Studi di Brescia = University of Brescia [UniBs]
Celotti, Andrea [Auteur]
Morgagni, Paolo [Auteur]
Vittimberga, Giovani [Auteur]
Hoelscher, Arnulf [Auteur]
Moenig, Stefan [Auteur]
Kołodziejczyk, Piotr [Auteur]
Richter, Piotr [Auteur]
Gockel, Ines [Auteur]
University Hospital Leipzig = Universitätsklinikum Leipzig
Piessen, Guillaume [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
da Costa, Paulo Matos [Auteur]
Davies, Andrew [Auteur]
University of Sussex
Baker, Cara [Auteur]
Allum, William [Auteur]
Romario, Uberto Fumagalli [Auteur]
de Pascale, Stefano [Auteur]
Rosati, Ricccardo [Auteur]
Reim, Daniel [Auteur]
Santos, Lucio Lara [Auteur]
D’ugo, Domenico [Auteur]
Wijnhoven, Bas [Auteur]
Degiuli, Maurizio [Auteur]
de Manzoni, Giovanni [Auteur]
Kielan, Wojciech [Auteur]
Frejlich, Ewelina [Auteur]
Schneider, Paul [Auteur]
Polkowski, Wojciech [Auteur]

Journal title :

Annals of Surgery

Pages :

823-831

Publisher :

Lippincott, Williams & Wilkins

Publication date :

2023-11-09

ISSN :

0003-4932

HAL domain(s) :

Sciences du Vivant [q-bio]/Cancer

English abstract : [en]

Objective: To assess the rate of textbook outcome (TO) and textbook oncological outcome (TOO) in the European population based on the GASTRODATA registry. Background: TO is a composite parameter assessing surgical quality ...
Show more >Objective: To assess the rate of textbook outcome (TO) and textbook oncological outcome (TOO) in the European population based on the GASTRODATA registry. Background: TO is a composite parameter assessing surgical quality and strongly correlates with improved overall survival. Following the standard of treatment for locally advanced gastric cancer, TOO was proposed as a quality and optimal multimodal treatment parameter. Methods: TO was achieved when all the following criteria were met: no intraoperative complications, radical resection according to the surgeon, pR0 resection, retrieval of at least 15 lymph nodes, no severe postoperative complications, no reintervention, no admission to the intensive care unit, no prolonged length of stay, no postoperative mortality and no hospital readmission. TOO was defined as TO with the addition of perioperative chemotherapy compliance. Results: Of the 2558 patients, 1700 were included in the analysis. TO was achieved in 1164 (68.5%) patients. The use of neoadjuvant chemotherapy [odds ratio (OR) = 1.33, 95% CI: 1.04–1.70] and D2 or D2+ lymphadenectomy (OR = 1.55, 95% CI: 1.15–2.10) had a positive impact on TO achievement. Older age (OR = 0.73, 95% CI: 0.54–0.94), pT3/4 (OR = 0.79, 95% CI: 0.63–0.99), ASA 3/4 (OR = 0.68, 95% CI: 0.54–0.86) and total gastrectomy (OR = 0.56, 95% CI: 0.45–0.70), had a negative impact on TO achievement. TOO was achieved in 388 (22.8%) patients. Older age (OR = 0.37, 95% CI: 0.27–0.53), pT3 or pT4 (OR = 0.52, 95% CI: 0.39–0.69), and ASA 3 or 4 (OR = 0.58, 95% CI: 0.43–0.79) had a negative impact on TOO achievement. Conclusions: Despite successively improved surgical outcomes, stage‐appropriate chemotherapy in adherence to the current guidelines for multimodal treatment of gastric cancer remains poor. Further implementation of oncologic quality metrics should include greater emphasis on perioperative chemotherapy and adequate lymphadenectomy.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL