Title :

Combining diabetes, sex, and menopause as meaningful clinical features associated with NASH and liver fibrosis in individuals with class II and III obesity: A retrospective cohort study

Author(s) :

Raverdy, Violeta [Auteur]
Chatelain, Estelle [Auteur]
Plateforme de bioinformatique et de biostatistique de Lille - PLBS [Bilille]
Plateformes Lilloises en Biologie et Santé - UAR 2014 - US 41 [PLBS]
Lasailly, Guillaume [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Caiazzo, Robert [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Vandel, Jimmy [Auteur]
Plateformes Lilloises en Biologie et Santé - UAR 2014 - US 41 [PLBS]
Verkindt, Helene [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Marciniak, Camille [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Legendre, Benjamin [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Bauvin, Pierre [Auteur]
Oukhouya-Daoud, Naima [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Baud, Gregory [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Chetboun, Mikael [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Vantyghem, Marie‐christine [Auteur]
Gnemmi, Viviane [Auteur]
Institut de Pathologie [CHU Lille]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Leteurtre, Emmanuelle [Auteur]
Service de pathologie [CHU Lille]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Staels, Bart [Auteur]
Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD]
Lefebvre, Philippe [Auteur]
Institut interdisciplinaire de l’innovation [I3]
Centre de Gestion Scientifique i3 [CGS i3]
Mathurin, Philippe [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Marot, Guillemette [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
MOdel for Data Analysis and Learning [MODAL]
Pattou, Francois [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]

Journal title :

Obesity

Pages :

3066-3076

Publisher :

Wiley

Publication date :

2023-11-21

ISSN :

1930-7381

HAL domain(s) :

Sciences du Vivant [q-bio]/Cancer

English abstract : [en]

Abstract Objective Steatotic liver disease (SLD) is frequent in individuals with obesity. In this study, type 2 diabetes (T2D), sex, and menopausal status were combined to refine the stratification of obesity regarding the ...
Show more >Abstract Objective Steatotic liver disease (SLD) is frequent in individuals with obesity. In this study, type 2 diabetes (T2D), sex, and menopausal status were combined to refine the stratification of obesity regarding the risk of advanced SLD and gain further insight into disease physiopathology. Methods This study enrolled 1446 participants with obesity from the ABOS cohort (NCT01129297), who underwent extensive phenotyping, including liver histology and transcriptome profiling. Hierarchical clustering was applied to classify participants. The prevalence of metabolic disorders associated with steatohepatitis (NASH) and liver fibrosis (F ≥ 2) was determined within each identified subgroup and aligned to clinical and biological characteristics. Results The prevalence of NASH and F ≥ 2 was, respectively, 9.5% ( N = 138/1446) and 11.7% ( N = 159/1365) in the overall population, 20.3% ( N = 107/726) and 21.1% ( N = 106/502) in T2D patients, and 3.4% ( N = 31/920) and 6.1% ( N = 53/863) in non‐T2D patients. NASH and F ≥ 2 prevalence was 15.4% (33/215) and 15.5% (32/206) among premenopausal women with T2D vs. 29.5% (33/112) and 30.3% ( N = 36/119) in postmenopausal women with T2D ( p < 0.01); and 21.0% (21/100) / 27.0% (24/89) in men with T2D ≥ age 50 years and 17.9% (17/95) / 18.5% (17/92) in men with T2D < age 50 years (NS). The distinct contribution of menopause was confirmed by the interaction between sex and age with respect to NASH among T2D patients ( p = 0.048). Finally, several NASH‐associated biological traits (lower platelet count; higher serum uric acid; gamma‐glutamyl transferase; aspartate aminotransferase) and liver expressed genes AKR1B10 and CCL20 were significantly associated with menopause in women with T2D but not with age in men with T2D. Conclusions This study unveiled a remarkably high prevalence of advanced SLD after menopause in women with T2D, associated with a dysfunctional biological liver profile.Show less >

Language :

Anglais

Popular science :

Non

Collections :

• Laboratoire Paul Painlevé - UMR 8524

Source :

Harvested from HAL