New farnesyltransferase inhibitors in the ...

Document type :
Article dans une revue scientifique
DOI :
10.1016/j.bmcl.2012.06.007
PMID :
22738631
Permalink :
http://hdl.handle.net/20.500.12210/11239
Title :
New farnesyltransferase inhibitors in the phenothiazine series
Author(s) :
Belei, Dalila [Auteur]
Dumea, Carmen [Auteur]
Samson, Alexandrina [Auteur]
Farce, Amaury [Auteur] orcid refId
Dubois, Joelle [Auteur]
Bicu, Elena [Auteur]
Ghinet, Alina [Auteur] refId
Journal title :
Bioorganic & Medicinal Chemistry Letters
Abbreviated title :
Bioorg. Med. Chem. Lett.
Volume number :
22
Pages :
4517-4522
Publication date :
2012-07-15
ISSN :
0960-894X
English keyword(s) :
Phenothiazine
Farnesyltransferase inhibitor
Triazole
Anticancer agent
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
The biological screening of the chemical library of our Organic Chemistry Department, carried out on an automated fluorescence-based FTase assay, allowed us to discover that a phenothiazine derivative (1d) was an inhibitor ...
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Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Inserm
Université de Lille
Collections :
Research team(s) :
Therapeutic innovation targetting inflammation
Submission date :
2019-05-17T13:08:47Z