Title :

Synthesis and anticancer activity of analogues of phenstatin, with a phenothiazine A-ring, as a new class of microtubule-targeting agents

Author(s) :

Abuhaie, Cristina-Maria [Auteur]
Bicu, Elena [Auteur]
Rigo, Benoit [Auteur]
Gautret, Philippe [Auteur]
Belei, Dalila [Auteur]
Farce, Amaury [Auteur]
Dubois, Joelle [Auteur]
Ghinet, Alina [Auteur]

Journal title :

Bioorganic & Medicinal Chemistry Letters

Abbreviated title :

Bioorg. Med. Chem. Lett.

Volume number :

23

Pages :

147-152

Publication date :

2013-01-01

ISSN :

0960-894X

English keyword(s) :

Tubulin
Microtubule-targeting agent
Phenothiazine derivative
Anticancer agent

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

A new family of microtubule-targeting agents with a phenothiazine A-ring was synthesized and evaluated for anti-proliferative activity and interaction with tubulin. These new derivatives showed significant activities against ...
Show more >A new family of microtubule-targeting agents with a phenothiazine A-ring was synthesized and evaluated for anti-proliferative activity and interaction with tubulin. These new derivatives showed significant activities against cellular proliferation and tubulin polymerization, rather similar to those of phenstatin. Phenothiazine derivative 21 proved to be the most potent compound synthesized with GI(50) values ranging from 29 to 93 nM on different cell lines. The same compound showed a better inhibition of COLO 205, A498, and MCF7 cell lines than the parent phenstatin.Show less >

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Therapeutic innovation targetting inflammation

Submission date :

2019-05-17T13:14:31Z