Synthesis and anticancer activity of ...
Type de document :
Article dans une revue scientifique
PMID :
URL permanente :
Titre :
Synthesis and anticancer activity of analogues of phenstatin, with a phenothiazine A-ring, as a new class of microtubule-targeting agents
Auteur(s) :
Abuhaie, Cristina-Maria [Auteur]
Bicu, Elena [Auteur]
Rigo, Benoit [Auteur]
Gautret, Philippe [Auteur]
Belei, Dalila [Auteur]
Farce, Amaury [Auteur]
Dubois, Joelle [Auteur]
Ghinet, Alina [Auteur]
Bicu, Elena [Auteur]
Rigo, Benoit [Auteur]
Gautret, Philippe [Auteur]
Belei, Dalila [Auteur]
Farce, Amaury [Auteur]
Dubois, Joelle [Auteur]
Ghinet, Alina [Auteur]
Titre de la revue :
Bioorganic & Medicinal Chemistry Letters
Nom court de la revue :
Bioorg. Med. Chem. Lett.
Numéro :
23
Pagination :
147-152
Date de publication :
2013-01-01
ISSN :
0960-894X
Mot(s)-clé(s) en anglais :
Tubulin
Microtubule-targeting agent
Phenothiazine derivative
Anticancer agent
Microtubule-targeting agent
Phenothiazine derivative
Anticancer agent
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
A new family of microtubule-targeting agents with a phenothiazine A-ring was synthesized and evaluated for anti-proliferative activity and interaction with tubulin. These new derivatives showed significant activities against ...
Lire la suite >A new family of microtubule-targeting agents with a phenothiazine A-ring was synthesized and evaluated for anti-proliferative activity and interaction with tubulin. These new derivatives showed significant activities against cellular proliferation and tubulin polymerization, rather similar to those of phenstatin. Phenothiazine derivative 21 proved to be the most potent compound synthesized with GI(50) values ranging from 29 to 93 nM on different cell lines. The same compound showed a better inhibition of COLO 205, A498, and MCF7 cell lines than the parent phenstatin.Lire moins >
Lire la suite >A new family of microtubule-targeting agents with a phenothiazine A-ring was synthesized and evaluated for anti-proliferative activity and interaction with tubulin. These new derivatives showed significant activities against cellular proliferation and tubulin polymerization, rather similar to those of phenstatin. Phenothiazine derivative 21 proved to be the most potent compound synthesized with GI(50) values ranging from 29 to 93 nM on different cell lines. The same compound showed a better inhibition of COLO 205, A498, and MCF7 cell lines than the parent phenstatin.Lire moins >
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Équipe(s) de recherche :
Therapeutic innovation targetting inflammation
Date de dépôt :
2019-05-17T13:14:31Z