Synthesis and biological evaluation of ...

Document type :
Article dans une revue scientifique
DOI :
10.1016/j.bmc.2013.03.064
PMID :
23618708
Permalink :
http://hdl.handle.net/20.500.12210/11245
Title :
Synthesis and biological evaluation of fluoro analogues of antimitotic phenstatin
Author(s) :
Ghinet, Alina [Auteur]
Tourteau, Aurelien [Auteur]
Rigo, Benoit [Auteur]
Stocker, Vivien [Auteur]
Leman, Marie [Auteur]
Farce, Amaury [Auteur]
Dubois, Joelle [Auteur]
Gautret, Philippe [Auteur]
Journal title :
Bioorganic & medicinal chemistry
Abbreviated title :
Bioorg. Med. Chem.
Volume number :
21
Pages :
2932-2940
Publication date :
2013-06-01
ISSN :
0968-0896
English keyword(s) :
Tubulin
Phenstatin
Eaton''s reagent
Fluorobenzophenone
Antimitotic agent
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
With the aim of investigating the influence of fluorine, in particular on the A-ring, a new series of fluoro analogues (7a-l) of phenstatin (3) was synthesized and tested for interactions with tubulin polymerization and ...
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Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Inserm
Université de Lille
Collections :
Research team(s) :
Therapeutic innovation targetting inflammation
Submission date :
2019-05-17T13:14:32Z