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Development of prilling process for ...
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Document type :
Article dans une revue scientifique
DOI :
10.1016/j.ijpharm.2015.11.051
PMID :
26656302
Permalink :
http://hdl.handle.net/20.500.12210/11267
Title :
Development of prilling process for biodegradable microspheres through experimental designs
Author(s) :
Violet, Fabien [Auteur]
Le, Minh-Quan [Auteur]
Michelle, Sergent [Auteur]
Guillaume, Bastiat [Auteur]
Tran, Van-Thanh [Auteur]
Venier-Julienne, Marie-Claire [Auteur]
Journal title :
International journal of pharmaceutics
Abbreviated title :
Int. J. Pharm.
Volume number :
498
Pages :
96-109
Publication date :
2016-02-10
ISSN :
0378-5173
English keyword(s) :
Glycofurol
Prilling
PLGA
Microsphere
Experimental design
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
The prilling process proposes a microparticle formulation easily transferable to the pharmaceutical production, leading to monodispersed and highly controllable microspheres. PLGA microspheres were used for carrying an ...
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The prilling process proposes a microparticle formulation easily transferable to the pharmaceutical production, leading to monodispersed and highly controllable microspheres. PLGA microspheres were used for carrying an encapsulated protein and adhered stem cells on its surface, proposing a tool for regeneration therapy against injured tissue. This work focused on the development of the production of PLGA microspheres by the prilling process without toxic solvent. The required production quality needed a complete optimization of the process. Seventeen parameters were studied through experimental designs and led to an acceptable production. The key parameters and mechanisms of formation were highlighted.Show less >
Audience :
Internationale
Popular science :
Non
Collections :
  • Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Research team(s) :
Therapeutic innovation targetting inflammation
Submission date :
2019-05-17T13:14:37Z
Université de Lille

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