Title :

A.-E. Dascalu et al.Separations of antifungal compounds in capillary electrophoresis with two anionic cyclodextrins.

Author(s) :

Dascalu, Anca-Elena [Auteur]
Ghinet, Alina [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Billamboz, Muriel [Auteur]
Lipka, Emmanuelle [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995

Journal title :

Electrophoresis

Abbreviated title :

Electrophoresis

Publication date :

2019-03-07

ISSN :

1522-2683

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

CD-CZE methods were developed for complete stereoisomeric separations of a series of six γ-lactam analogues, of which some were neutral, or cationic depending on the background electrolyte nature. The tested cyclodextrin ...
Show more >CD-CZE methods were developed for complete stereoisomeric separations of a series of six γ-lactam analogues, of which some were neutral, or cationic depending on the background electrolyte nature. The tested cyclodextrin was the versatile sulfobutylether- β-CD, used either in a phosphate buffer using capillaries dynamically coated with polyethylene oxide or in a borate buffer using uncoated capillaries. Long-end and short-end modes and concentration variations of chiral selectors allowed finding conditions of complete separation of four out of the six derivatives (i.e., 1, 2, 3, and 4) in short run times, confirming their broad range of applications. To separate the two last compounds, the highly sulfated- γ-CD was examined as chiral selector in acidic phosphate conditions. The enantiomers of the γ-lactam analogues 5 and 6 were baseline resolved with 5.5 and 4%, respectively as concentration in the buffer.Show less >

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Therapeutic innovation targetting inflammation

Submission date :

2019-05-17T13:14:48Z