A.-E. Dascalu et al.Separations of antifungal ...
Type de document :
Article dans une revue scientifique
DOI :
PMID :
URL permanente :
Titre :
A.-E. Dascalu et al.Separations of antifungal compounds in capillary electrophoresis with two anionic cyclodextrins.
Auteur(s) :
Dascalu, Anca-Elena [Auteur]
Ghinet, Alina [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Billamboz, Muriel [Auteur]
Lipka, Emmanuelle [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Ghinet, Alina [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Billamboz, Muriel [Auteur]
Lipka, Emmanuelle [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Titre de la revue :
Electrophoresis
Nom court de la revue :
Electrophoresis
Date de publication :
2019-03-07
ISSN :
1522-2683
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
CD-CZE methods were developed for complete stereoisomeric separations of a series of six γ-lactam analogues, of which some were neutral, or cationic depending on the background electrolyte nature. The tested cyclodextrin ...
Lire la suite >CD-CZE methods were developed for complete stereoisomeric separations of a series of six γ-lactam analogues, of which some were neutral, or cationic depending on the background electrolyte nature. The tested cyclodextrin was the versatile sulfobutylether- β-CD, used either in a phosphate buffer using capillaries dynamically coated with polyethylene oxide or in a borate buffer using uncoated capillaries. Long-end and short-end modes and concentration variations of chiral selectors allowed finding conditions of complete separation of four out of the six derivatives (i.e., 1, 2, 3, and 4) in short run times, confirming their broad range of applications. To separate the two last compounds, the highly sulfated- γ-CD was examined as chiral selector in acidic phosphate conditions. The enantiomers of the γ-lactam analogues 5 and 6 were baseline resolved with 5.5 and 4%, respectively as concentration in the buffer.Lire moins >
Lire la suite >CD-CZE methods were developed for complete stereoisomeric separations of a series of six γ-lactam analogues, of which some were neutral, or cationic depending on the background electrolyte nature. The tested cyclodextrin was the versatile sulfobutylether- β-CD, used either in a phosphate buffer using capillaries dynamically coated with polyethylene oxide or in a borate buffer using uncoated capillaries. Long-end and short-end modes and concentration variations of chiral selectors allowed finding conditions of complete separation of four out of the six derivatives (i.e., 1, 2, 3, and 4) in short run times, confirming their broad range of applications. To separate the two last compounds, the highly sulfated- γ-CD was examined as chiral selector in acidic phosphate conditions. The enantiomers of the γ-lactam analogues 5 and 6 were baseline resolved with 5.5 and 4%, respectively as concentration in the buffer.Lire moins >
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Équipe(s) de recherche :
Therapeutic innovation targetting inflammation
Date de dépôt :
2019-05-17T13:14:48Z