Title :

Novel Benchmark Values for Open Major Anatomic Liver Resection in Non-cirrhotic Patients

Author(s) :

Sousa da Silva, Richard [Auteur]
University hospital of Zurich [Zurich]
Breuer, Eva [Auteur]
University hospital of Zurich [Zurich]
Shankar, Sadhana [Auteur]
King's College Hospital [KCH]
Kawakatsu, Shoji [Auteur]
Nagoya City University [Nagoya, Japan]
Hołówko, Wacław [Auteur]
Warszawski Uniwersytet Medyczny [Polska] = Medical University of Warsaw [Poland] = Université de Médecine de Varsovie [Pologne]
Santos Coelho, João [Auteur]
Centro Hospitalar Universitário Lisboa Central
Jeddou, Heithem [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Sugiura, Teiichi [Auteur]
Shizuoka Cancer Center Hospital
Ghallab, Mohammed [Auteur]
Centre Hépato-Biliaire [Hôpital Paul Brousse] [CHB]
da Silva, Doris [Auteur]
Hôpital Beaujon [AP-HP]
Watanabe, Genki [Auteur]
Tōkyō teikoku daigaku = University of Tokyo [Tokyo] [UTokyo]
Botea, Florin [Auteur]
Fundeni Clinical Institute = Institutul Clinic Fundeni [Bucarest, Roumanie]
Sakai, Nozomu [Auteur]
Chiba University Hospital
Addeo, Pietro [Auteur]
Pôle des Pathologies Digestives Hépatiques et Transplantation [Hôpital Hautepierre-Strasbourg]
Tōkyō teikoku daigaku = University of Tokyo [Tokyo] [UTokyo]
Tzedakis, Stylianos [Auteur]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Health data- and model- driven Knowledge Acquisition [HeKA]
Hôpital Cochin [AP-HP]
Bartsch, Fabian [Auteur]
Lille économie management - UMR 9221 [LEM]
Balcer, Kaja [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Lim, Chetana [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Werey, Fabien [Auteur]
Chirurgie digestive [CHU Amiens]
Lopez-Lopez, Victor [Auteur]
Instituto Tecnológico de Tijuana = Tijuana Institute of Technology [Tijuana]
Peralta Montero, Luciana [Auteur]
Hospital Italiano de Buenos Aires
Sanchez Claria, Rodrigo [Auteur]
Hospital Italiano de Buenos Aires
Leiting, Jennifer [Auteur]
Mayo Clinic
Vachharajani, Neeta [Auteur]
Washington University School of Medicine [Saint Louis, MO]
Hopping, Eve [Auteur]
Royal Adelaide Hospital [Adelaide Australia]
Torres, Orlando [Auteur]
Presidente Dutra Hospital [São Luís]
Hirano, Satoshi [Auteur]
Hokkaido University Hospital [Sapporo]
Andel, Daan [Auteur]
University Medical Center [Utrecht] [UMCU]
Hagendoorn, Jeroen [Auteur]
University Medical Center [Utrecht] [UMCU]
Psica, Alicja [Auteur]
St James's University Hospital
Ravaioli, Matteo [Auteur]
Istituti di Ricovero e Cura a Carattere Scientifico [IRCCS]
Ahn, Keun Soon [Auteur]
Keimyung University
Reese, Tim [Auteur]
Semmelweis University of Medicine [Budapest]
Montes, Leonardo [Auteur]
University Hospital [Buenos Aires]
Gunasekaran, Ganesh [Auteur]
Icahn School of Medicine at Mount Sinai [New York] [MSSM]
Alcázar, Cándido [Auteur]
General University Hospital of Alicante
Lim, Jin Hong [Auteur]
Yonsei University
Haroon, Muhammad [Auteur]
Bahria International Hospital Orchard [Lahore]
Lu, Qian [Auteur]
Tsinghua University [Beijing] [THU]
Castaldi, Antonio [Auteur]
CHU Nice [Cimiez]
Orimo, Tatsuya [Auteur]
Hokkaido University Hospital [Sapporo]
Moeckli, Beat [Auteur]
Hôpitaux Universitaires de Genève [HUG]
Abadía, Teresa [Auteur]
Hospital Universitario Miguel Servet
Ruffolo, Luis [Auteur]
University of Rochester [USA]
Dib Hasan, Josefina [Auteur]
Hospital Alemán [Buenos Aires]
Ratti, Francesca [Auteur]
IRCCS Ospedale San Raffaele [Milan, Italy]
Kauffmann, Emmanuele [Auteur]
University of Pisa [Italy] = Università di Pisa [Italia] = Université de Pise [Italie] [UniPi]
de Wilde, Roeland [Auteur]
Erasmus University Medical Center [Rotterdam] [Erasmus MC]
Polak, Wojciech [Auteur]
Erasmus University Medical Center [Rotterdam] [Erasmus MC]
Boggi, Ugo [Auteur]
University of Pisa [Italy] = Università di Pisa [Italia] = Université de Pise [Italie] [UniPi]
Aldrighetti, Luca [Auteur]
IRCCS Ospedale San Raffaele [Milan, Italy]
Mccormack, Lucas [Auteur]
Hospital Alemán [Buenos Aires]
Hernandez-Alejandro, Roberto [Auteur]
University of Rochester [USA]
Serrablo, Alejandro [Auteur]
Hospital Universitario Miguel Servet
Toso, Christian [Auteur]
Hôpitaux universitaires de Genève = University Hospitals of Geneva [HUG]
Taketomi, Akinobu [Auteur]
Hokkaido University Hospital [Sapporo]
Gugenheim, Jean [Auteur]
Hôpital Cimiez [Nice] [CHU]
Dong, Jiahong [Auteur]
Tsinghua University [Beijing] [THU]
Hanif, Faisal [Auteur]
Bahria International Hospital Orchard [Lahore]
Park, Joon Seong [Auteur]
Yonsei University
Ramia, José [Auteur]
General University Hospital of Alicante
Schwartz, Myron [Auteur]
Icahn School of Medicine at Mount Sinai [New York] [MSSM]
Ramisch, Diego [Auteur]
Favaloro Foundation
de Oliveira, Michelle [Auteur]
University hospital of Zurich [Zurich]
Oldhafer, Karl [Auteur]
Semmelweis University of Medicine [Budapest]
Kang, Koo Jeong [Auteur]
Keimyung University
Cescon, Matteo [Auteur]
IRCCS Azienda Ospedaliero-Universitaria di Bologna [AOUB]
Lodge, Peter [Auteur]
Leeds Teaching Hospitals NHS Trust
Rinkes, Inne [Auteur]
University Medical Center [Utrecht] [UMCU]
Noji, Takehiro [Auteur]
Hokkaido University of Science
Thomson, John-Edwin [Auteur]
Royal Adelaide Hospital [Adelaide Australia]
Goh, Su Kah [Auteur]
Royal Adelaide Hospital [Adelaide Australia]
Chapman, William [Auteur]
Washington University in Saint Louis [WUSTL]
Cleary, Sean [Auteur]
Mayo Clinic [Rochester]
Pekolj, Juan [Auteur]
Hospital Italiano de Buenos Aires
Regimbeau, Jean-Marc [Auteur]
CHU Amiens-Picardie
Scatton, Olivier [Auteur]
Cytométrie Pitié-Salpêtrière [PASS-CYPS]
Truant, Stéphanie [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Lang, Hauke [Auteur]
University Medical Center [Mainz]
Fuks, David [Auteur]
Hôpital Cochin [AP-HP]
Bachellier, Philippe [Auteur]
Université de Strasbourg [UNISTRA]
Ohtsuka, Masayuki [Auteur]
Chiba University Hospital
Popescu, Irinel [Auteur]
Fundeni Clinical Institute = Institutul Clinic Fundeni [Bucarest, Roumanie]
Hasegawa, Kiyoshi [Auteur]
Tōkyō teikoku daigaku = University of Tokyo [Tokyo] [UTokyo]
Lesurtel, Mickaël [Auteur]
Hôpital Beaujon [AP-HP]
Adam, René [Auteur]
Hôpital Paul Brousse
Cherqui, Daniel [Auteur]
Hôpital Paul Brousse
Uesaka, Katsuhiko [Auteur]
Shizuoka Cancer Center Hospital
Boudjema, Karim [Auteur]
Hôpital Sud [CHU Rennes]
Pinto-Marques, Hugo [Auteur]
Centro Hospitalar Universitário Lisboa Central
Grąt, Michał [Auteur]
Warszawski Uniwersytet Medyczny [Polska] = Medical University of Warsaw [Poland] = Université de Médecine de Varsovie [Pologne]
Petrowsky, Henrik [Auteur]
University hospital of Zurich [Zurich]
Ebata, Tomoki [Auteur]
Nagoya University
Prachalias, Andreas [Auteur]
King's College Hospital [KCH]
Robles-Campos, Ricardo [Auteur]
Instituto Murciano de Investigación Biosanitaria Pascual Parrilla [IMIB]
Clavien, Pierre-Alain [Auteur]
University hospital of Zurich [Zurich]

Journal title :

Annals of Surgery

Pages :

748-755

Publisher :

Lippincott, Williams & Wilkins

Publication date :

2023-11-19

ISSN :

0003-4932

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Objective: This study aims at establishing benchmark values for best achievable outcomes following open major anatomic hepatectomy for liver tumors of all dignities. Background: Outcomes after open major hepatectomies vary ...
Show more >Objective: This study aims at establishing benchmark values for best achievable outcomes following open major anatomic hepatectomy for liver tumors of all dignities. Background: Outcomes after open major hepatectomies vary widely lacking reference values for comparisons among centers, indications, types of resections, and minimally invasive procedures. Methods: A standard benchmark methodology was used covering consecutive patients, who underwent open major anatomic hepatectomy from 44 high-volume liver centers from 5 continents over a 5-year period (2016–2020). Benchmark cases were low-risk non-cirrhotic patients without significant comorbidities treated in high-volume centers (≥30 major liver resections/year). Benchmark values were set at the 75th percentile of median values of all centers. Minimum follow-up period was 1 year in each patient. Results: Of 8044 patients, 2908 (36%) qualified as benchmark (low-risk) cases. Benchmark cutoffs for all indications include R0 resection ≥78%; liver failure (grade B/C) ≤10%; bile leak (grade B/C) ≤18%; complications ≥grade 3 and CCI ® ≤46% and ≤9 at 3 months, respectively. Benchmark values differed significantly between malignant and benign conditions so that reference values must be adjusted accordingly. Extended right hepatectomy (H1, 4-8 or H4-8) disclosed a higher cutoff for liver failure, while extended left (H1-5,8 or H2-5,8) were associated with higher cutoffs for bile leaks, but had superior oncologic outcomes, when compared to formal left hepatectomy (H1-4 or H2-4). The minimal follow-up for a conclusive outcome evaluation following open anatomic major resection must be 3 months. Conclusion: These new benchmark cutoffs for open major hepatectomy provide a powerful tool to convincingly evaluate other approaches including parenchymal-sparing procedures, laparoscopic/robotic approaches, and alternative treatments, such as ablation therapy, irradiation, or novel chemotherapy regimens.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Lille Économie Management (LEM) - UMR 9221

Source :

Harvested from HAL