Mg2+ Transporters in Digestive Cancers

Auwercx, Julie; Rybarczyk, Pierre; Kischel, Philippe; Dhennin-Duthille, Isabelle; Chatelain, Denis; Sevestre, Henri; Van Seuningen, Isabelle; Ouadid-Ahidouch, Halima; Jonckheere, Nicolas; Gautier, Mathieu

Document type :

Compte-rendu et recension critique d'ouvrage: Autre communication scientifique (congrès sans actes - poster - séminaire...)

DOI :

10.3390/nu13010210

Title :

Mg2+ Transporters in Digestive Cancers

Author(s) :

Auwercx, Julie [Auteur]
Rybarczyk, Pierre [Auteur]
Kischel, Philippe [Auteur]
Dhennin-Duthille, Isabelle [Auteur]
Chatelain, Denis [Auteur]
Sevestre, Henri [Auteur]
Van Seuningen, Isabelle [Auteur]

Ouadid-Ahidouch, Halima [Auteur]
Jonckheere, Nicolas [Auteur]

Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Gautier, Mathieu [Auteur]
Laboratoire de Physiologie Cellulaire et Moléculaire - UR UPJV 4667 [LPCM]

Journal title :

Nutrients

Pages :

210

Publisher :

MDPI

Publication date :

2021-01-13

ISSN :

2072-6643

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Despite magnesium (Mg2+) representing the second most abundant cation in the cell, its role in cellular physiology and pathology is far from being elucidated. Mg2+ homeostasis is regulated by Mg2+ transporters including ...
Show more >Despite magnesium (Mg2+) representing the second most abundant cation in the cell, its role in cellular physiology and pathology is far from being elucidated. Mg2+ homeostasis is regulated by Mg2+ transporters including Mitochondrial RNA Splicing Protein 2 (MRS2), Transient Receptor Potential Cation Channel Subfamily M, Member 6/7 (TRPM6/7), Magnesium Transporter 1 (MAGT1), Solute Carrier Family 41 Member 1 (SCL41A1), and Cyclin and CBS Domain Divalent Metal Cation Transport Mediator (CNNM) proteins. Recent data show that Mg2+ transporters may regulate several cancer cell hallmarks. In this review, we describe the expression of Mg2+ transporters in digestive cancers, the most common and deadliest malignancies worldwide. Moreover, Mg2+ transporters’ expression, correlation and impact on patient overall and disease-free survival is analyzed using Genotype Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) datasets. Finally, we discuss the role of these Mg2+ transporters in the regulation of cancer cell fates and oncogenic signaling pathways.Show less >

Language :

Anglais

Popular science :

Non

Collections :

Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL

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