Title :

A comparison of changes in bone turnover markers after gastric bypass and sleeve gastrectomy, and their association with markers of interest.

Author(s) :

Paccou, Julien [Auteur]
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]
Thuillier, Dorothée [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Courtalin, Marion [Auteur]
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]
Pigny, Pascal [Auteur]
Miniaturisation pour la Synthèse, l’Analyse et la Protéomique - UAR 3290 [MSAP]
Labreuche, Julien [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Cortet, Bernard [Auteur]
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]
Pattou, Francois [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]

Journal title :

Surgery for Obesity and Related Diseases

Pages :

373-383

Publisher :

Elsevier

Publication date :

2022-01-08

ISSN :

1550-7289

English keyword(s) :

Bone turnover markers
Bariatric surgery
Roux-en-Y gastric bypass
Sleeve gastrectomy
Sclerostin

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BackgroundIt is still debated whether differences in bone turnover markers (BTMs) exist between the 2 most popular bariatric surgery procedures (Roux-en-Y gastric bypass [RYGB] and sleeve gastrectomy [SG]).ObjectivesTo ...
Show more >BackgroundIt is still debated whether differences in bone turnover markers (BTMs) exist between the 2 most popular bariatric surgery procedures (Roux-en-Y gastric bypass [RYGB] and sleeve gastrectomy [SG]).ObjectivesTo compare changes in BTMs after RYGB and SG, and to investigate their association with predefined markers of interest.SettingUniversity hospital, Lille, France.MethodsAn ancillary investigation of a prospective cohort was conducted. SG patients with severe obesity ≥40 years were matched one-to-one to RYGB patients for age, sex, body mass index (BMI), and menopausal status. BTMs, as well as predefined markers of interest, were measured at baseline, 12, and 24 months after bariatric surgery.ResultsSixty-four patients (66% women) had a mean (standard deviation [SD]) age of 49.6 years (5.1) and a mean (SD) BMI of 45.0 kg/m2 (6.0). From baseline to 12 months, a significant increase in BTMs was observed in both groups (P < .001). Moreover, RYGB was associated with a greater increase in C-terminal telopeptide (β-CTX) and procollagen type 1 N-terminal propeptide (PINP) compared with SG (P < .0001). From 12 to 24 months, a significant decrease in BTMs was observed in both groups, but no significant differences were found between RYGB and SG. However, BTMs did not return to baseline levels. The changes in PINP and β-CTX at 12 months were independently associated with the type of surgical procedure, after adjusting for weight or each predefined marker of interest (all P < .0001).ConclusionRYGB was associated with a greater increase in BTMs than SG at 12 and 24 months.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Collections :

• Miniaturisation pour la Synthèse, l'Analyse et la Protéomique (MSAP) - USR 3290

Source :

Harvested from HAL