Title :

Characteristics of Bipolar Patients with Cognitive Impairment of Suspected Neurodegenerative Origin: A Multicenter Cohort.

Author(s) :

Musat, Esteban Munoz [Auteur]
Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
Marlinge, Emeline [Auteur]
Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
Leroy, Mélanie [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Olié, Emilie [Auteur]
Neuropsychiatrie : recherche épidémiologique et clinique [PSNREC]
Magnin, Eloi [Auteur]
Centre Mémoire de Ressources et de Recherche [CHRU de Besançon] [CMRR]
Laboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481) [NEURO]
Lebert, Florence [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Gabelle, Audrey [Auteur]
Hôpital Gui de Chauliac [CHU Montpellier]
Bennabi, Djamila [Auteur]
Laboratoire de Neurosciences Intégratives et Cliniques - UFC (UR 481) [NEURO]
Blanc, Frederic [Auteur]
Centre Mémoire Ressources et Recherche [Strasbourg] [CMRR Strasbourg]
Paquet, Claire [Auteur]
Optimisation thérapeutique en Neuropsychopharmacologie [OPTeN (UMR_S 1144 / U1144)]
Cognat, Emmanuel [Auteur]
Optimisation thérapeutique en Neuropsychopharmacologie [OPTeN (UMR_S 1144 / U1144)]

Journal title :

Journal of Personalized Medicine

Abbreviated title :

J Pers Med

Volume number :

11

Pages :

1183

Publication date :

2021-12-03

ISSN :

2075-4426

English keyword(s) :

bipolar disorder
cognition
dementia
Alzheimer's disease
biomarkers
Parkinsonism
neurodegenerescence

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Bipolar disorder is associated with an increased risk of dementia with aging. Little is known regarding this association, limiting appropriate diagnosis and management. We aimed to describe the characteristics of bipolar ...
Show more >Bipolar disorder is associated with an increased risk of dementia with aging. Little is known regarding this association, limiting appropriate diagnosis and management. We aimed to describe the characteristics of bipolar patients with late cognitive impairment for whom the hypothesis of an underlying neurodegenerative disease had been raised. We performed a retrospective multicenter study, recruiting bipolar patients over 50 years old from five French tertiary memory centers who had undergone cerebrospinal fluid (CSF) biomarker assessment for Alzheimer’s disease (AD). Clinical, neuropsychological, and paraclinical characteristics were analyzed and 78 patients were included. The mean age at the onset of cognitive impairment was 62.4 years (±9.2). The mean MMSE score was 22.8 (±4.5), the mean FAB was 11.7 (±3.9), and the mean FCRST was 15.8 (±7.4)/36.8 (±9.7) (free/total recall). A total of 48.6% of the patients displayed cognitive fluctuations, and 38.2% showed cognitive improvement during follow-ups; and 56.3% of the patients showed Parkinsonism, of which 12.7% had never received antipsychotics. Among patients who underwent DAT-scans, 35.3% displayed dopaminergic denervation; 10.3% of patients had CSF AD biological signature (“A+ T+” profile), while 56.4% had other abnormal CSF profiles. Thus, clinical presentation was dominated by executive dysfunction, episodic memory impairment, fluctuating cognition, and a high frequency of Parkinsonism. Specifically, high frequency of delusional episodes suggests limited tolerance of psychotropic drugs. Most patients had abnormal CSF biomarker profiles, but only a minority displayed AD’s specific biomarker signature. Therefore, while our results unveil shared common neurocognitive features in bipolar patients with cognitive impairment of suspected neurodegenerative origin they suggest a participation of various underlying pathologies rather than a common degenerative mechanism in the pathophysiology of this condition.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Submission date :

2024-06-24T21:21:46Z
2024-07-05T08:12:57Z