Title :

Fifty-nine bp repeat polymorphism in the uncommon intron 36 of the human mucin gene MUC5B.

Author(s) :

Desseyn, Jean-Luc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Rousseau, Karine [Auteur]
Laine, Anne [Auteur]

Journal title :

Electrophoresis

Abbreviated title :

Electrophoresis

Volume number :

20

Pages :

493-6

Publication date :

1999-03-01

ISSN :

0173-0835

English keyword(s) :

Base Sequence
DNA
Complementary
Humans
Introns
Molecular Sequence Data
Mucin-5B
Mucins
Polymorphism
Genetic
Tandem Repeat Sequences

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

A variable number of tandem repeat (VNTR) polymorphism within the intron 36 of the human mucin gene MUC5B, which is mapped to chromosome 11 band p15.5, have been identified using Southern blotting experiments. This ...
Show more >A variable number of tandem repeat (VNTR) polymorphism within the intron 36 of the human mucin gene MUC5B, which is mapped to chromosome 11 band p15.5, have been identified using Southern blotting experiments. This polymorphism can be easily assayed by polymerase chain reaction (PCR) to detect linkage of inherited disorder. Five alleles were observed in 86 unrelated individuals due to 3-8 direct perfect repeats of 59 bp. This repeat has the particularity to begin at the end of the preceding exon. Southern blot experiments revealed the locus specificity of the repeat. The sequence of the repeat unit does not match the consensus sequence of Chi-related minisatellites.Show less >

Language :

Anglais

Audience :

Non spécifiée

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2019-07-09T09:05:43Z
2019-07-09T09:42:37Z