Fifty-nine bp repeat polymorphism in the ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Fifty-nine bp repeat polymorphism in the uncommon intron 36 of the human mucin gene MUC5B.
Auteur(s) :
Desseyn, Jean-Luc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Rousseau, Karine [Auteur]
Laine, Anne [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Rousseau, Karine [Auteur]
Laine, Anne [Auteur]
Titre de la revue :
Electrophoresis
Nom court de la revue :
Electrophoresis
Numéro :
20
Pagination :
493-6
Date de publication :
1999-03-01
ISSN :
0173-0835
Mot(s)-clé(s) en anglais :
Base Sequence
DNA
Complementary
Humans
Introns
Molecular Sequence Data
Mucin-5B
Mucins
Polymorphism
Genetic
Tandem Repeat Sequences
DNA
Complementary
Humans
Introns
Molecular Sequence Data
Mucin-5B
Mucins
Polymorphism
Genetic
Tandem Repeat Sequences
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
A variable number of tandem repeat (VNTR) polymorphism within the intron 36 of the human mucin gene MUC5B, which is mapped to chromosome 11 band p15.5, have been identified using Southern blotting experiments. This ...
Lire la suite >A variable number of tandem repeat (VNTR) polymorphism within the intron 36 of the human mucin gene MUC5B, which is mapped to chromosome 11 band p15.5, have been identified using Southern blotting experiments. This polymorphism can be easily assayed by polymerase chain reaction (PCR) to detect linkage of inherited disorder. Five alleles were observed in 86 unrelated individuals due to 3-8 direct perfect repeats of 59 bp. This repeat has the particularity to begin at the end of the preceding exon. Southern blot experiments revealed the locus specificity of the repeat. The sequence of the repeat unit does not match the consensus sequence of Chi-related minisatellites.Lire moins >
Lire la suite >A variable number of tandem repeat (VNTR) polymorphism within the intron 36 of the human mucin gene MUC5B, which is mapped to chromosome 11 band p15.5, have been identified using Southern blotting experiments. This polymorphism can be easily assayed by polymerase chain reaction (PCR) to detect linkage of inherited disorder. Five alleles were observed in 86 unrelated individuals due to 3-8 direct perfect repeats of 59 bp. This repeat has the particularity to begin at the end of the preceding exon. Southern blot experiments revealed the locus specificity of the repeat. The sequence of the repeat unit does not match the consensus sequence of Chi-related minisatellites.Lire moins >
Langue :
Anglais
Audience :
Non spécifiée
Date de dépôt :
2019-07-09T09:05:43Z
2019-07-09T09:42:37Z
2019-07-09T09:42:37Z
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