Title :

Evolutionary history of the 11p15 human mucin gene family.

Author(s) :

Desseyn, Jean-Luc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Buisine, Marie-Pierre [Auteur]

Porchet, N [Auteur]
Aubert, J P [Auteur]
Degand, P [Auteur]
Laine, Anne [Auteur]

Journal title :

Journal of molecular evolution

Abbreviated title :

J Mol Evol

Volume number :

46

Pages :

102-6

Publication date :

1998-01-01

ISSN :

0022-2844

English keyword(s) :

Base Sequence
Chromosomes
Human
Pair 11
Conserved Sequence
Evolution
Molecular
Humans
Molecular Sequence Data
Mucin 5AC
Mucin-2
Mucin-5B
Mucins

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The four human mucin genes MUC6, MUC2, MUC5AC, and MUC5B are located at chromosome 11p15.5. It has been demonstrated that the three mucins MUC2, MUC5AC, and MUC5B contain several Cys-subdomains of 108 amino acid residues. ...
Show more >The four human mucin genes MUC6, MUC2, MUC5AC, and MUC5B are located at chromosome 11p15.5. It has been demonstrated that the three mucins MUC2, MUC5AC, and MUC5B contain several Cys-subdomains of 108 amino acid residues. In contrast, little information is available concerning MUC6. These Cys-subdomains contain 10 cysteine residues that have a highly conserved position. We present here a coherent probable evolutionary history of this human gene family after comparison of the nucleotide sequences of these Cys-subdomains. The three MUC loci MUC2, MUC5AC, and MUC5B may have evolved from a common ancestral gene by two successive duplications. Moreover, we can postulate that MUC5AC and MUC5B have evolved in a concerted manner, while MUC2 has evolved separately.Show less >

Language :

Anglais

Audience :

Non spécifiée

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• Lille Neurosciences & Cognition (LilNCog) - U 1172

Submission date :

2019-07-09T09:07:16Z
2019-07-09T09:53:33Z