Evolutionary history of the 11p15 human ...
Type de document :
Article dans une revue scientifique: Article original
DOI :
PMID :
URL permanente :
Titre :
Evolutionary history of the 11p15 human mucin gene family.
Auteur(s) :
Desseyn, Jean-Luc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Buisine, Marie-Pierre [Auteur]
Porchet, N [Auteur]
Aubert, J P [Auteur]
Degand, P [Auteur]
Laine, Anne [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Buisine, Marie-Pierre [Auteur]
Porchet, N [Auteur]
Aubert, J P [Auteur]
Degand, P [Auteur]
Laine, Anne [Auteur]
Titre de la revue :
Journal of molecular evolution
Nom court de la revue :
J Mol Evol
Numéro :
46
Pagination :
102-6
Date de publication :
1998-01-01
ISSN :
0022-2844
Mot(s)-clé(s) en anglais :
Base Sequence
Chromosomes
Human
Pair 11
Conserved Sequence
Evolution
Molecular
Humans
Molecular Sequence Data
Mucin 5AC
Mucin-2
Mucin-5B
Mucins
Chromosomes
Human
Pair 11
Conserved Sequence
Evolution
Molecular
Humans
Molecular Sequence Data
Mucin 5AC
Mucin-2
Mucin-5B
Mucins
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
The four human mucin genes MUC6, MUC2, MUC5AC, and MUC5B are located at chromosome 11p15.5. It has been demonstrated that the three mucins MUC2, MUC5AC, and MUC5B contain several Cys-subdomains of 108 amino acid residues. ...
Lire la suite >The four human mucin genes MUC6, MUC2, MUC5AC, and MUC5B are located at chromosome 11p15.5. It has been demonstrated that the three mucins MUC2, MUC5AC, and MUC5B contain several Cys-subdomains of 108 amino acid residues. In contrast, little information is available concerning MUC6. These Cys-subdomains contain 10 cysteine residues that have a highly conserved position. We present here a coherent probable evolutionary history of this human gene family after comparison of the nucleotide sequences of these Cys-subdomains. The three MUC loci MUC2, MUC5AC, and MUC5B may have evolved from a common ancestral gene by two successive duplications. Moreover, we can postulate that MUC5AC and MUC5B have evolved in a concerted manner, while MUC2 has evolved separately.Lire moins >
Lire la suite >The four human mucin genes MUC6, MUC2, MUC5AC, and MUC5B are located at chromosome 11p15.5. It has been demonstrated that the three mucins MUC2, MUC5AC, and MUC5B contain several Cys-subdomains of 108 amino acid residues. In contrast, little information is available concerning MUC6. These Cys-subdomains contain 10 cysteine residues that have a highly conserved position. We present here a coherent probable evolutionary history of this human gene family after comparison of the nucleotide sequences of these Cys-subdomains. The three MUC loci MUC2, MUC5AC, and MUC5B may have evolved from a common ancestral gene by two successive duplications. Moreover, we can postulate that MUC5AC and MUC5B have evolved in a concerted manner, while MUC2 has evolved separately.Lire moins >
Langue :
Anglais
Audience :
Non spécifiée
Collections :
Date de dépôt :
2019-07-09T09:07:16Z
2019-07-09T09:53:33Z
2019-07-09T09:53:33Z
Fichiers
- 1997JMolEvol.pdf
- Version éditeur
- Accès confidentiel
- Accéder au document