Acyl-coenzyme a binding protein (ACBP) - ...
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Compte-rendu et recension critique d'ouvrage
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Title :
Acyl-coenzyme a binding protein (ACBP) - a risk factor for cancer diagnosis and an inhibitor of immunosurveillance
Author(s) :
Montégut, Léa [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Centre de Recherche des Cordeliers [CRC]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Liu, Peng [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Centre de Recherche des Cordeliers [CRC]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Zhao, Liwei [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Centre de Recherche des Cordeliers [CRC]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Pérez-Lanzón, María [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Centre de Recherche des Cordeliers [CRC]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Chen, Hui [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Centre de Recherche des Cordeliers [CRC]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Mao, Misha [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Centre de Recherche des Cordeliers [CRC]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Zhang, Shuai [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Centre de Recherche des Cordeliers [CRC]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Derosa, Lisa [Auteur]
Immunologie anti-tumorale et immunothérapie des cancers [ITIC]
Université Paris-Saclay
Institut Gustave Roussy [IGR]
Naour, Julie Le [Auteur]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Lambertucci, Flavia [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Centre de Recherche des Cordeliers [CRC]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Mingoia, Silvia [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Centre de Recherche des Cordeliers [CRC]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Nogueira-Recalde, Uxía [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Centre de Recherche des Cordeliers [CRC]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Mena-Osuna, Rafael [Auteur]
Herranz-Montoya, Irene [Auteur]
Djouder, Nabil [Auteur]
Spanish National Cancer Research Center [CNIO]
Baulande, Sylvain [Auteur]
Université Paris Sciences et Lettres [PSL]
Pan, Hui [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Centre de Recherche des Cordeliers [CRC]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Joseph, Adrien [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Centre de Recherche des Cordeliers [CRC]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Messaoudene, Meriem [Auteur]
Centre Hospitalier de l'Université de Montréal [CHUM]
Centre de Recherche du Centre Hospitalier de l’Université de Montréal [CR CHUM]
Routy, Bertrand [Auteur]
Centre Hospitalier de l'Université de Montréal [CHUM]
Centre de Recherche du Centre Hospitalier de l’Université de Montréal [CR CHUM]
Fidelle, Marine [Auteur]
Immunologie anti-tumorale et immunothérapie des cancers [ITIC]
Ahmed, Tarek Ben [Auteur]
Caron, Olivier [Auteur]
Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]
Operational Research, Knowledge And Data [ORKAD]
Busson, Pierre [Auteur]
Aspects métaboliques et systémiques de l'oncogénèse pour de nouvelles approches thérapeutiques [METSY]
Boulate, David [Auteur]
Hôpital Nord [CHU - APHM]
Deschasaux-Tanguy, Mélanie [Auteur]
Réseau National Alimentation Cancer Recherche (réseau NACRe)
Nutritional Epidemiology Research Team | Equipe de Recherche en Epidémiologie Nutritionnelle [EREN [CRESS - U1153 / UMR_A 1125]]
Arnault, Nathalie [Auteur]
Nutritional Epidemiology Research Team | Equipe de Recherche en Epidémiologie Nutritionnelle [EREN [CRESS - U1153 / UMR_A 1125]]
Pol, Jonathan [Auteur]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Piaggio, Eliane [Auteur]
Université Paris Sciences et Lettres [PSL]
Immunité et cancer [U932]
Touvier, Mathilde [Auteur]
Nutritional Epidemiology Research Team | Equipe de Recherche en Epidémiologie Nutritionnelle [EREN [CRESS - U1153 / UMR_A 1125]]
Zitvogel, Laurence [Auteur]
Immunologie anti-tumorale et immunothérapie des cancers [ITIC]
Université Paris-Saclay
Institut Gustave Roussy [IGR]
Delaloge, Suzette [Auteur]
Département de médecine oncologique [Gustave Roussy]
Martins, Isabelle [Auteur]
Institut Gustave Roussy [IGR]
Institut universitaire de France [IUF]
Métabolisme, Cancer et Immunité [CRC - UMR_S 1138]
Kroemer, Guido [Auteur]
Cancer Research and Personalized Medicine - CARPEM [Paris] [SIRIC CARPEM]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Hopital Saint-Louis [AP-HP] [AP-HP]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Centre de Recherche des Cordeliers [CRC]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Liu, Peng [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Centre de Recherche des Cordeliers [CRC]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Zhao, Liwei [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Centre de Recherche des Cordeliers [CRC]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Pérez-Lanzón, María [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Centre de Recherche des Cordeliers [CRC]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Chen, Hui [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Centre de Recherche des Cordeliers [CRC]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Mao, Misha [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Centre de Recherche des Cordeliers [CRC]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Zhang, Shuai [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Centre de Recherche des Cordeliers [CRC]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Derosa, Lisa [Auteur]
Immunologie anti-tumorale et immunothérapie des cancers [ITIC]
Université Paris-Saclay
Institut Gustave Roussy [IGR]
Naour, Julie Le [Auteur]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Lambertucci, Flavia [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Centre de Recherche des Cordeliers [CRC]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Mingoia, Silvia [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Centre de Recherche des Cordeliers [CRC]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Nogueira-Recalde, Uxía [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Centre de Recherche des Cordeliers [CRC]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Mena-Osuna, Rafael [Auteur]
Herranz-Montoya, Irene [Auteur]
Djouder, Nabil [Auteur]
Spanish National Cancer Research Center [CNIO]
Baulande, Sylvain [Auteur]
Université Paris Sciences et Lettres [PSL]
Pan, Hui [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Centre de Recherche des Cordeliers [CRC]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Joseph, Adrien [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Centre de Recherche des Cordeliers [CRC]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Messaoudene, Meriem [Auteur]
Centre Hospitalier de l'Université de Montréal [CHUM]
Centre de Recherche du Centre Hospitalier de l’Université de Montréal [CR CHUM]
Routy, Bertrand [Auteur]
Centre Hospitalier de l'Université de Montréal [CHUM]
Centre de Recherche du Centre Hospitalier de l’Université de Montréal [CR CHUM]
Fidelle, Marine [Auteur]
Immunologie anti-tumorale et immunothérapie des cancers [ITIC]
Ahmed, Tarek Ben [Auteur]
Caron, Olivier [Auteur]

Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 [CRIStAL]
Operational Research, Knowledge And Data [ORKAD]
Busson, Pierre [Auteur]
Aspects métaboliques et systémiques de l'oncogénèse pour de nouvelles approches thérapeutiques [METSY]
Boulate, David [Auteur]
Hôpital Nord [CHU - APHM]
Deschasaux-Tanguy, Mélanie [Auteur]
Réseau National Alimentation Cancer Recherche (réseau NACRe)
Nutritional Epidemiology Research Team | Equipe de Recherche en Epidémiologie Nutritionnelle [EREN [CRESS - U1153 / UMR_A 1125]]
Arnault, Nathalie [Auteur]
Nutritional Epidemiology Research Team | Equipe de Recherche en Epidémiologie Nutritionnelle [EREN [CRESS - U1153 / UMR_A 1125]]
Pol, Jonathan [Auteur]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Piaggio, Eliane [Auteur]
Université Paris Sciences et Lettres [PSL]
Immunité et cancer [U932]
Touvier, Mathilde [Auteur]
Nutritional Epidemiology Research Team | Equipe de Recherche en Epidémiologie Nutritionnelle [EREN [CRESS - U1153 / UMR_A 1125]]
Zitvogel, Laurence [Auteur]
Immunologie anti-tumorale et immunothérapie des cancers [ITIC]
Université Paris-Saclay
Institut Gustave Roussy [IGR]
Delaloge, Suzette [Auteur]
Département de médecine oncologique [Gustave Roussy]
Martins, Isabelle [Auteur]
Institut Gustave Roussy [IGR]
Institut universitaire de France [IUF]
Métabolisme, Cancer et Immunité [CRC - UMR_S 1138]
Kroemer, Guido [Auteur]
Cancer Research and Personalized Medicine - CARPEM [Paris] [SIRIC CARPEM]
Institut Gustave Roussy [IGR]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Journal title :
Molecular Cancer
Pages :
187
Publisher :
BioMed Central
Publication date :
2024-09-06
ISSN :
1476-4598
English keyword(s) :
Immunosurveillance
Immunotherapy
Neuroendocrine factors
Non-small cell lung cancer
Precocious detection
Immunotherapy
Neuroendocrine factors
Non-small cell lung cancer
Precocious detection
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Background: The plasma concentrations of acyl coenzyme A binding protein (ACBP, also known as diazepam-binding inhibitor, DBI, or 'endozepine') increase with age and obesity, two parameters that are also amongst the most ...
Show more >Background: The plasma concentrations of acyl coenzyme A binding protein (ACBP, also known as diazepam-binding inhibitor, DBI, or 'endozepine') increase with age and obesity, two parameters that are also amongst the most important risk factors for cancer.Methods: We measured ACBP/DBI in the plasma from cancer-free individuals, high-risk patients like the carriers of TP53 or BRCA1/2 mutations, and non-syndromic healthy subjects who later developed cancer. In mice, the neutralization of ACBP/DBI was used in models of non-small cell lung cancer (NSCLC) and breast cancer development and as a combination treatment with chemoimmunotherapy (chemotherapy + PD-1 blockade) in the context of NSCLC and sarcomas. The anticancer T cell response upon ACBP/DBI neutralization was characterized by flow cytometry and single-cell RNA sequencing.Results: Circulating levels of ACBP/DBI were higher in patients with genetic cancer predisposition (BRCA1/2 or TP53 germline mutations) than in matched controls. In non-syndromic cases, high ACBP/DBI levels were predictive of future cancer development, and especially elevated in patients who later developed lung cancer. In preclinical models, ACBP/DBI neutralization slowed down breast cancer and NSCLC development and enhanced the efficacy of chemoimmunotherapy in NSCLC and sarcoma models. When combined with chemoimmunotherapy, the neutralizing monoclonal antibody against ACBP/DBI reduced the frequency of regulatory T cells in the tumor bed, modulated the immune checkpoint profile, and increased activation markers.Conclusion: These findings suggest that ACBP/DBI acts as an endogenous immune suppressor. We conclude that elevation of ACBP/DBI constitutes a risk factor for the development of cancer and that ACBP/DBI is an actionable target for improving cancer immunosurveillance.Show less >
Show more >Background: The plasma concentrations of acyl coenzyme A binding protein (ACBP, also known as diazepam-binding inhibitor, DBI, or 'endozepine') increase with age and obesity, two parameters that are also amongst the most important risk factors for cancer.Methods: We measured ACBP/DBI in the plasma from cancer-free individuals, high-risk patients like the carriers of TP53 or BRCA1/2 mutations, and non-syndromic healthy subjects who later developed cancer. In mice, the neutralization of ACBP/DBI was used in models of non-small cell lung cancer (NSCLC) and breast cancer development and as a combination treatment with chemoimmunotherapy (chemotherapy + PD-1 blockade) in the context of NSCLC and sarcomas. The anticancer T cell response upon ACBP/DBI neutralization was characterized by flow cytometry and single-cell RNA sequencing.Results: Circulating levels of ACBP/DBI were higher in patients with genetic cancer predisposition (BRCA1/2 or TP53 germline mutations) than in matched controls. In non-syndromic cases, high ACBP/DBI levels were predictive of future cancer development, and especially elevated in patients who later developed lung cancer. In preclinical models, ACBP/DBI neutralization slowed down breast cancer and NSCLC development and enhanced the efficacy of chemoimmunotherapy in NSCLC and sarcoma models. When combined with chemoimmunotherapy, the neutralizing monoclonal antibody against ACBP/DBI reduced the frequency of regulatory T cells in the tumor bed, modulated the immune checkpoint profile, and increased activation markers.Conclusion: These findings suggest that ACBP/DBI acts as an endogenous immune suppressor. We conclude that elevation of ACBP/DBI constitutes a risk factor for the development of cancer and that ACBP/DBI is an actionable target for improving cancer immunosurveillance.Show less >
Language :
Anglais
Popular science :
Non
ANR Project :
Le système RUSH : un système chemo-génétique pour la manipulation in vivo de circuits de communication.
Ciblage du cuivre mitochondrial pour moduler l'inflammation
Energizing the failing heart
Control du métabolisme et de l'autophagie par ACBP/DBI
Next-generation phenotypic screening for oncological applications
Université de Paris
Microbiota-centered interventions to solve antibiotics-induced primary resistance to immune checkpoint inhibitors
Lung cancer prevention and interception
Ciblage du cuivre mitochondrial pour moduler l'inflammation
Energizing the failing heart
Control du métabolisme et de l'autophagie par ACBP/DBI
Next-generation phenotypic screening for oncological applications
Université de Paris
Microbiota-centered interventions to solve antibiotics-induced primary resistance to immune checkpoint inhibitors
Lung cancer prevention and interception
Collections :
Source :
Submission date :
2024-09-22T02:02:53Z
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