Title :

Caspases shutdown nonsense-mediated mRNA decay during apoptosis

Author(s) :

Jia, J [Auteur]
Institut de biologie de Lille - IBL [IBLI]
Institut Pasteur de Lille
Furlan, A. [Auteur]
Institut de biologie de Lille - IBL [IBLI]
Institut Pasteur de Lille
Gonzalez-Hilarion, S [Auteur]
Institut Pasteur [Paris] [IP]
Leroy, C. [Auteur]
Institut de biologie de Lille - IBL [IBLI]
Institut Pasteur de Lille
Gruenert, D [Auteur]
Tulasne, D [Auteur]
Institut de biologie de Lille - IBL [IBLI]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Lejeune, F. [Auteur]
Institut de biologie de Lille - IBL [IBLI]
Institut Pasteur de Lille

Journal title :

Cell death and differentiation

Pages :

1754-1763

Publisher :

Nature Publishing Group

Publication date :

2015-11

ISSN :

1350-9047

HAL domain(s) :

Sciences du Vivant [q-bio]
Sciences du Vivant [q-bio]/Biologie cellulaire

English abstract : [en]

Nonsense-mediated mRNA decay (NMD) is an mRNA surveillance mechanism that plays integral roles in eliminating mRNAs with premature termination codons to prevent the synthesis of truncated proteins that could be pathogenic. ...
Show more >Nonsense-mediated mRNA decay (NMD) is an mRNA surveillance mechanism that plays integral roles in eliminating mRNAs with premature termination codons to prevent the synthesis of truncated proteins that could be pathogenic. One response to the accumulation of detrimental proteins is apoptosis, which involves the activation of enzymatic pathways leading to protein and nucleic acid cleavage and culminating in cell death. It is not clear whether NMD is required to ensure the accurate expression of apoptosis genes or is no longer necessary since cytotoxic proteins are not an issue during cell death. The present study shows that caspases cleave the two NMD factors UPF1 and UPF2 during apoptosis impairing NMD. Our results demonstrate a new regulatory pathway for NMD that occurs during apoptosis and provide evidence for role of the UPF cleaved fragments in apoptosis and NMD inhibition.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL

Submission date :

2024-10-08T02:50:57Z