Title :

Impact of Therapeutic Doses of Prednisolone and Other Glucocorticoids on Insulin Secretion from Human Islets.

Author(s) :

Tijani, Omolara Khadijat [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Moreno Lopez, Maria [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Louvet, Isaline [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Acosta Montalvo, Ana [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Coddeville, anaïs [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Gmry, Valery [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Conte, Julien K. [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Pattou, Francois [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Vantyghem, Marie-Christine [Auteur]
Recherche translationnelle sur le diabète (RTD) - U1190
Saponaro, Chiara [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Bonner, Caroline [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Stephanie, Espiard [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]

Journal title :

Annales d'Endocrinologie = Annals of Endocrinology

Abbreviated title :

Ann Endocrinol (Paris)

Volume number :

86

Pages :

101676

Publisher :

Elsevier

Publication date :

2024-12-08

ISSN :

2213-3941

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Introduction Glucocorticoid-induced diabetes (GCID) is a prevalent health issue, generally attributed to insulin resistance. High doses of dexamethasone (DEX) are known to inhibit glucose-stimulated insulin secretion ...
Show more >Introduction Glucocorticoid-induced diabetes (GCID) is a prevalent health issue, generally attributed to insulin resistance. High doses of dexamethasone (DEX) are known to inhibit glucose-stimulated insulin secretion (GSIS), but the effects of lower doses, commonly used in chronic therapy, and equipotent doses of other glucocorticoids (GCs) such as hydrocortisone (HC) and prednisone (PRED) remain underexplored. This study aimed to investigate these effects in vitro, and explore variations between patients. Materials and methods Dynamic perifusion assays were conducted on human islets to evaluate the impact of different GCs on GSIS. The islets were treated for 24 h with 250 nM PRED and other GCs at equipotent anti-inflammatory doses (HC: 1 μM; DEX: 38 nM). Results In 11 human islet donor preparations, 250 nM PRED, corresponding to a clinical oral dose of 5 mg/day, significantly inhibited the first and second phase of GSIS: area under the curve (AUC) decreased by 32.3% (P < 0.001), first phase by 41.5% (P < 0.001), and second phase by 38.4% (P < 0.001). Despite interindividual differences in GSIS response to PRED, no significant differences were observed according to body mass index, gender or age. Comparing the effects of GCs at equipotent anti-inflammatory doses, DEX had a more pronounced inhibitory effect on GSIS than HC or PRED. Conclusions In vitro, low-dose PRED treatment significantly impacted GSIS. DEX had a more unfavorable impact on GSIS than HC or PRED, indicating that metabolic effects do not align with anti-inflammatory potency.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Recherche translationnelle sur le diabète (RTD) - U1190

Submission date :

2025-01-04T22:02:52Z
2025-01-16T08:01:23Z