Title :

Clinical and Electrophysiological Characteristics of 23 French Patients With Neurolymphomatosis.

Author(s) :

Asmani, Dylan [Auteur]
Service de Neurologie [CHU Limoges]
Chanson, J. B. [Auteur]
Tard, Celine [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Svahn, J. [Auteur]
Pegat, A. [Auteur]
Magot, A. [Auteur]
Péréon, Y. [Auteur]
Camdessanché, J. P. [Auteur]
Naudin, S. [Auteur]
Colin, O. [Auteur]
Taieb, G. [Auteur]
Coulibaly, I. [Auteur]
Magy, L. [Auteur]
Frachet, Simon [Auteur]
Service de Neurologie [CHU Limoges]

Journal title :

Muscle Nerve

Abbreviated title :

Muscle Nerve

Publisher :

Wiley

Publication date :

2025-01-12

ISSN :

1097-4598

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Introduction/Aims Neurolymphomatosis is a hematological condition defined by the direct infiltration of malignant lymphomatous cells into the peripheral nervous system. Since nerve conduction studies may disclose demyelinating ...
Show more >Introduction/Aims Neurolymphomatosis is a hematological condition defined by the direct infiltration of malignant lymphomatous cells into the peripheral nervous system. Since nerve conduction studies may disclose demyelinating features, clinicians may misdiagnose neurolymphomatosis as chronic inflammatory demyelinating polyneuropathy (CIDP). This study aimed to determine whether patients with neurolymphomatosis met the 2021 revised criteria for CIDP. Methods We retrospectively analyzed 23 patients with primary or secondary neurolymphomatosis from nine French hospitals. We analyzed whether patients with a diagnosis of neurolymphomatosis met the 2010 and 2021 CIDP criteria. Results 152 motor nerves were analyzed, and conduction blocks were found in 13.8% of them. Eight patients (34.7%) demonstrated at least one conduction block. Other demyelinating parameters fulfilling the 2021 CIDP criteria were rare, including reduced conduction velocities (1.7%), prolonged distal motor latencies (3%), absent F-waves (12.4%), and prolonged F-wave latencies (7.7%). Five patients met the 2010 CIDP criteria, whereas only one met the 2021 CIDP criteria. Discussion Demyelinating features are rare in neurolymphomatosis, and a conduction block is the most frequent abnormality. Consequently, only one patient met the 2021 criteria for CIDP diagnosis. This is likely attributable to the inclusion of sensory criteria. Furthermore, the new criteria emphasize the importance of identifying red flags, such as pain or monoclonal gammopathy, which could suggest an alternative diagnosis to CIDP. Clinicians should consider neurolymphomatosis in patients who present with red flags or atypical CIDP.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Submission date :

2025-01-18T22:00:59Z
2025-01-29T08:40:45Z