Upper Limb Evaluation and One-Year Follow ...
Type de document :
Article dans une revue scientifique
PMID :
URL permanente :
Titre :
Upper Limb Evaluation and One-Year Follow Up of Non-Ambulant Patients with Spinal Muscular Atrophy: An Observational Multicenter Trial
Auteur(s) :
Seferian, Andreea Mihaela [Auteur]
Centre de recherche en myologie
Moraux, Amelie [Auteur]
Centre de recherche en myologie
Canal, Aurélie [Auteur]
Centre de recherche en myologie
Decostre, Valérie [Auteur]
Centre de recherche en myologie
Diebate, Oumar [Auteur]
Le Moing, Anne-Gaëlle [Auteur]
CHU Amiens-Picardie
Gidaro, Teresa [Auteur]
Centre de recherche en myologie
Deconinck, Nicolas [Auteur]
Van Parys, Frauke [Auteur]
Vereecke, Wendy [Auteur]
Wittevrongel, Sylvia [Auteur]
Annoussamy, Melanie [Auteur]
Centre de recherche en myologie
Mayer, Michele [Auteur]
CHU Trousseau [APHP]
Maincent, Kim [Auteur]
CHU Trousseau [APHP]
Cuisset, Jean-Marie [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Tiffreau, Vincent [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS]
Denis, Severine [Auteur]
Centre Hospitalier Universitaire de Liège [CHU-Liège]
Jousten, Virginie [Auteur]
Centre Hospitalier Universitaire de Liège [CHU-Liège]
Quijano-Roy, Susana [Auteur]
Université de Versailles Saint-Quentin-en-Yvelines [UVSQ]
Voit, Thomas [Auteur]
Centre de recherche en myologie
Hogrel, Jean-Yves [Auteur]
Centre de recherche en myologie
Servais, Laurent [Auteur]
Centre de recherche en myologie
Centre de recherche en myologie
Moraux, Amelie [Auteur]
Centre de recherche en myologie
Canal, Aurélie [Auteur]
Centre de recherche en myologie
Decostre, Valérie [Auteur]
Centre de recherche en myologie
Diebate, Oumar [Auteur]
Le Moing, Anne-Gaëlle [Auteur]
CHU Amiens-Picardie
Gidaro, Teresa [Auteur]
Centre de recherche en myologie
Deconinck, Nicolas [Auteur]
Van Parys, Frauke [Auteur]
Vereecke, Wendy [Auteur]
Wittevrongel, Sylvia [Auteur]
Annoussamy, Melanie [Auteur]
Centre de recherche en myologie
Mayer, Michele [Auteur]
CHU Trousseau [APHP]
Maincent, Kim [Auteur]
CHU Trousseau [APHP]
Cuisset, Jean-Marie [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Tiffreau, Vincent [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS]
Denis, Severine [Auteur]
Centre Hospitalier Universitaire de Liège [CHU-Liège]
Jousten, Virginie [Auteur]
Centre Hospitalier Universitaire de Liège [CHU-Liège]
Quijano-Roy, Susana [Auteur]
Université de Versailles Saint-Quentin-en-Yvelines [UVSQ]
Voit, Thomas [Auteur]
Centre de recherche en myologie
Hogrel, Jean-Yves [Auteur]
Centre de recherche en myologie
Servais, Laurent [Auteur]
Centre de recherche en myologie
Titre de la revue :
PLoS One
Nom court de la revue :
PLoS One
Numéro :
10
Date de publication :
2015-04-10
ISSN :
1932-6203
Mot(s)-clé(s) en anglais :
Mesh:Noninvasive Ventilation
Mesh:Muscular Atrophy
Mesh:Spinal/physiopathology*
Mesh:Young Adult
Mesh:Upper Extremity/physiopathology*
Mesh:Adolescent
Mesh:Adult
Mesh:Child
Mesh:Female
Mesh:Follow-Up Studies
Mesh:Hand Strength/physiology
Mesh:Humans
Mesh:Spinal Muscular Atrophies of Childhood/physiopathology
Mesh:Pinch Strength/physiology
Mesh:Male
Mesh:Muscular Atrophy
Mesh:Spinal/physiopathology*
Mesh:Young Adult
Mesh:Upper Extremity/physiopathology*
Mesh:Adolescent
Mesh:Adult
Mesh:Child
Mesh:Female
Mesh:Follow-Up Studies
Mesh:Hand Strength/physiology
Mesh:Humans
Mesh:Spinal Muscular Atrophies of Childhood/physiopathology
Mesh:Pinch Strength/physiology
Mesh:Male
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Assessment of the upper limb strength in non-ambulant neuromuscular patients remains challenging. Although potential outcome measures have been reported, longitudinal data demonstrating sensitivity to clinical evolution ...
Lire la suite >Assessment of the upper limb strength in non-ambulant neuromuscular patients remains challenging. Although potential outcome measures have been reported, longitudinal data demonstrating sensitivity to clinical evolution in spinal muscular atrophy patients are critically lacking. Our study recruited 23 non-ambulant patients, 16 patients (males/females = 6/10; median age 15.4 years with a range from 10.7 to 31.1 years) with spinal muscular atrophy type II and 7 patients (males/females = 2/5; median age 19.9 years with a range from 8.3 to 29.9 years) with type III. The Brooke functional score was on median 3 with a range from 2 to 6. The average total vital capacity was 46%, and seven patients required non-invasive ventilation at night. Patients were assessed at baseline, 6 months, and 1 year using the Motor Function Measure and innovative devices MyoGrip, MyoPinch, and MoviPlate, which assess handgrip strength, key pinch strength, and hand/finger extension-flexion function, respectively. The study demonstrated the feasibility and reliability of these measures for all patients, and sensitivity to negative changes after the age of 14 years. The younger patients showed an increase of the distal force in the follow-up period. The distal force measurements and function were correlated to different functional scales. These data represent an important step in the process of validating these devices as potential outcome measures for future clinical trials.Lire moins >
Lire la suite >Assessment of the upper limb strength in non-ambulant neuromuscular patients remains challenging. Although potential outcome measures have been reported, longitudinal data demonstrating sensitivity to clinical evolution in spinal muscular atrophy patients are critically lacking. Our study recruited 23 non-ambulant patients, 16 patients (males/females = 6/10; median age 15.4 years with a range from 10.7 to 31.1 years) with spinal muscular atrophy type II and 7 patients (males/females = 2/5; median age 19.9 years with a range from 8.3 to 29.9 years) with type III. The Brooke functional score was on median 3 with a range from 2 to 6. The average total vital capacity was 46%, and seven patients required non-invasive ventilation at night. Patients were assessed at baseline, 6 months, and 1 year using the Motor Function Measure and innovative devices MyoGrip, MyoPinch, and MoviPlate, which assess handgrip strength, key pinch strength, and hand/finger extension-flexion function, respectively. The study demonstrated the feasibility and reliability of these measures for all patients, and sensitivity to negative changes after the age of 14 years. The younger patients showed an increase of the distal force in the follow-up period. The distal force measurements and function were correlated to different functional scales. These data represent an important step in the process of validating these devices as potential outcome measures for future clinical trials.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Univ. Littoral Côte d’Opale
Univ. Artois
Université de Lille
Univ. Artois
Université de Lille
Équipe(s) de recherche :
Activité Physique, Muscle, Santé (APMS)
Date de dépôt :
2019-09-24T10:02:03Z
2020-05-29T09:48:47Z
2020-05-29T09:51:11Z
2020-05-29T09:48:47Z
2020-05-29T09:51:11Z
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- journal.pone.0121799.PDF
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