Upper Limb Strength and Function Changes ...
Type de document :
Article dans une revue scientifique
PMID :
URL permanente :
Titre :
Upper Limb Strength and Function Changes during a One-Year Follow-Up in Non-Ambulant Patients with Duchenne Muscular Dystrophy: An Observational Multicenter Trial
Auteur(s) :
Seferian, Andreea Mihaela [Auteur]
Centre de recherche en myologie
Moraux, Amelie [Auteur]
Centre de recherche en myologie
Annoussamy, Melanie [Auteur]
Centre de recherche en myologie
Canal, Aurélie [Auteur]
Centre de recherche en myologie
Decostre, Valérie [Auteur]
Centre de recherche en myologie
Diebate, Oumar [Auteur]
Le Moing, Anne-Gaëlle [Auteur]
CHU Amiens-Picardie
Gidaro, Teresa [Auteur]
Centre de recherche en myologie
Deconinck, Nicolas [Auteur]
Van Parys, Frauke [Auteur]
Vereecke, Wendy [Auteur]
Wittevrongel, Sylvia [Auteur]
Mayer, Michele [Auteur]
CHU Trousseau [APHP]
Maincent, Kim [Auteur]
CHU Trousseau [APHP]
Desguerre, Isabelle [Auteur]
Hôpital Necker - Enfants Malades [AP-HP]
Themar-Noel, Christine [Auteur]
Centre de recherche en myologie
Cuisset, Jean-Marie [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Tiffreau, Vincent [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS]
Denis, Severine [Auteur]
Centre Hospitalier Universitaire de Liège [CHU-Liège]
Jousten, Virginie [Auteur]
Centre Hospitalier Universitaire de Liège [CHU-Liège]
Quijano-Roy, Susana [Auteur]
Hôpital Raymond Poincaré [AP-HP]
Voit, Thomas [Auteur]
Hogrel, Jean-Yves [Auteur]
Centre de recherche en myologie
Servais, Laurent [Auteur]
Centre de recherche en myologie
Centre de recherche en myologie
Moraux, Amelie [Auteur]
Centre de recherche en myologie
Annoussamy, Melanie [Auteur]
Centre de recherche en myologie
Canal, Aurélie [Auteur]
Centre de recherche en myologie
Decostre, Valérie [Auteur]
Centre de recherche en myologie
Diebate, Oumar [Auteur]
Le Moing, Anne-Gaëlle [Auteur]
CHU Amiens-Picardie
Gidaro, Teresa [Auteur]
Centre de recherche en myologie
Deconinck, Nicolas [Auteur]
Van Parys, Frauke [Auteur]
Vereecke, Wendy [Auteur]
Wittevrongel, Sylvia [Auteur]
Mayer, Michele [Auteur]
CHU Trousseau [APHP]
Maincent, Kim [Auteur]
CHU Trousseau [APHP]
Desguerre, Isabelle [Auteur]
Hôpital Necker - Enfants Malades [AP-HP]
Themar-Noel, Christine [Auteur]
Centre de recherche en myologie
Cuisset, Jean-Marie [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Tiffreau, Vincent [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS]
Denis, Severine [Auteur]
Centre Hospitalier Universitaire de Liège [CHU-Liège]
Jousten, Virginie [Auteur]
Centre Hospitalier Universitaire de Liège [CHU-Liège]
Quijano-Roy, Susana [Auteur]
Hôpital Raymond Poincaré [AP-HP]
Voit, Thomas [Auteur]
Hogrel, Jean-Yves [Auteur]
Centre de recherche en myologie
Servais, Laurent [Auteur]
Centre de recherche en myologie
Titre de la revue :
PLoS One
Nom court de la revue :
PLoS One
Numéro :
10
Date de publication :
2015-02-02
ISSN :
1932-6203
Mot(s)-clé(s) en anglais :
Mesh:Humans
Mesh:Muscle Strength*/drug effects
Mesh:Adolescent
Mesh:Muscular Dystrophy
Mesh:Duchenne/physiopathology*
Mesh:Muscular Dystrophy
Mesh:Duchenne/drug therapy
Mesh:Recovery of Function*/drug effects
Mesh:Upper Extremity/physiopathology*
Mesh:Young Adult
Mesh:Adult
Mesh:Male
Mesh:Female
Mesh:Child
Mesh:Follow-Up Studies
Mesh:Muscle Strength*/drug effects
Mesh:Adolescent
Mesh:Muscular Dystrophy
Mesh:Duchenne/physiopathology*
Mesh:Muscular Dystrophy
Mesh:Duchenne/drug therapy
Mesh:Recovery of Function*/drug effects
Mesh:Upper Extremity/physiopathology*
Mesh:Young Adult
Mesh:Adult
Mesh:Male
Mesh:Female
Mesh:Child
Mesh:Follow-Up Studies
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
BACKGROUND: Upper limb evaluation of patients with Duchenne Muscular Dystrophy is crucially important to evaluations of efficacy of new treatments in non-ambulant patients. In patients who have lost ambulation, there are ...
Lire la suite >BACKGROUND: Upper limb evaluation of patients with Duchenne Muscular Dystrophy is crucially important to evaluations of efficacy of new treatments in non-ambulant patients. In patients who have lost ambulation, there are few validated and informative outcome measures. In addition, longitudinal data demonstrating sensitivity to clinical evolution of outcome measures over short-term periods are lacking. METHODS: We report here the results of a one-year multicenter study using specifically designed tools to assess grip, pinch strength, and hand function in wheelchair-bound patients. Our study assessed 53 non-ambulant patients with Duchenne muscular dystrophy aged 17.1 ± 4.8 years (range: 9 - 28.1 years). The average Brooke functional score of these patients was 4.6 ± 1.1. The average forced vital capacity was 44.5% predicted and 19 patients used non-invasive ventilation. Patients were assessed at baseline, 6 months, and one year using the Motor Function Measure and innovative devices (namely the MyoSet composed of MyoGrip, MyoPinch, and MoviPlate). RESULTS: Our study confirmed preliminary data previously reported regarding feasibility of use and of reliability of the MyoSet and the correlation at baseline between distal strength and clinical outcomes such as FVC, Brooke score, age, and duration since loss of ambulation. A significant correlation was observed between the distal upper limb strength and clinical variables. The sensitive dynamometers (MyoGrip and MyoPinch) and MoviPlate captured a 12-month change in non-ambulant Duchenne muscular dystrophy patients of all ages. BACKGROUND: ClinicalTrials.gov NCT00993161 NCT00993161.Lire moins >
Lire la suite >BACKGROUND: Upper limb evaluation of patients with Duchenne Muscular Dystrophy is crucially important to evaluations of efficacy of new treatments in non-ambulant patients. In patients who have lost ambulation, there are few validated and informative outcome measures. In addition, longitudinal data demonstrating sensitivity to clinical evolution of outcome measures over short-term periods are lacking. METHODS: We report here the results of a one-year multicenter study using specifically designed tools to assess grip, pinch strength, and hand function in wheelchair-bound patients. Our study assessed 53 non-ambulant patients with Duchenne muscular dystrophy aged 17.1 ± 4.8 years (range: 9 - 28.1 years). The average Brooke functional score of these patients was 4.6 ± 1.1. The average forced vital capacity was 44.5% predicted and 19 patients used non-invasive ventilation. Patients were assessed at baseline, 6 months, and one year using the Motor Function Measure and innovative devices (namely the MyoSet composed of MyoGrip, MyoPinch, and MoviPlate). RESULTS: Our study confirmed preliminary data previously reported regarding feasibility of use and of reliability of the MyoSet and the correlation at baseline between distal strength and clinical outcomes such as FVC, Brooke score, age, and duration since loss of ambulation. A significant correlation was observed between the distal upper limb strength and clinical variables. The sensitive dynamometers (MyoGrip and MyoPinch) and MoviPlate captured a 12-month change in non-ambulant Duchenne muscular dystrophy patients of all ages. BACKGROUND: ClinicalTrials.gov NCT00993161 NCT00993161.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Univ. Littoral Côte d’Opale
Univ. Artois
Université de Lille
Univ. Artois
Université de Lille
Équipe(s) de recherche :
Activité Physique, Muscle, Santé (APMS)
Date de dépôt :
2019-09-24T10:02:06Z
2020-05-29T09:01:22Z
2020-05-29T09:01:22Z
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- journal.pone.0113999.PDF
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