Title :

Mast cell density and its clinical relevance in Waldenström's macroglobulinemia

Author(s) :

Lemal, Richard [Auteur]
CHU Clermont-Ferrand
Université Clermont Auvergne [UCA]
Poulain, Stéphanie [Auteur]
Miniaturisation pour la Synthèse, l’Analyse et la Protéomique - UAR 3290 [MSAP]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Service d'Hématologie Cellulaire [Lille]
Ledoux‐pilon, Albane [Auteur]
CHU Estaing [Clermont-Ferrand]
Université Clermont Auvergne [UCA]
Veronese, Lauren [Auteur]
Service Cytogénétique Médicale [CHU Clermont-Ferrand]
Imagerie Moléculaire et Stratégies Théranostiques [IMoST]
Tchirkov, Andrei [Auteur]
Service Cytogénétique Médicale [CHU Clermont-Ferrand]
Imagerie Moléculaire et Stratégies Théranostiques [IMoST]
Lebecque, Benjamin [Auteur]
Role of intra-Clonal Heterogeneity and Leukemic environment in ThErapy Resistance of chronic leukemias [CHELTER]
Tassin, Thomas [Auteur]
Role of intra-Clonal Heterogeneity and Leukemic environment in ThErapy Resistance of chronic leukemias [CHELTER]
Bay, Jacques‐olivier [Auteur]
CHU Clermont-Ferrand
Charlotte, Frédéric [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Nguyen‐khac, Florence [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Berger, Marc [Auteur]
Role of intra-Clonal Heterogeneity and Leukemic environment in ThErapy Resistance of chronic leukemias [CHELTER]
Godfraind, Catherine [Auteur]
Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte [M2iSH]
Service Neurologie [CHU Clermont-Ferrand]
Ysebaert, Loïc [Auteur]
Service Hématologie - IUCT-Oncopole [CHU Toulouse]
Institut Universitaire du Cancer de Toulouse - Oncopole [IUCT Oncopole - UMR 1037]
Centre de Recherches en Cancérologie de Toulouse [CRCT]
Davi, Frédéric [Auteur]
Sorbonne Université [SU]
CHU Pitié-Salpêtrière [AP-HP]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Pereira, Bruno [Auteur]
CHU Clermont-Ferrand
Leblond, Véronique [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Hermine, Olivier [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Hôpital Necker - Enfants Malades [AP-HP]
Guièze, Romain [Auteur]
Role of intra-Clonal Heterogeneity and Leukemic environment in ThErapy Resistance of chronic leukemias [CHELTER]
Pagès, Franck [Auteur]
Hôpital Européen Georges Pompidou [APHP] [HEGP]
Immunologie et Cancérologie Intégratives = Integrative Cancer Immunology [CRC]
Tournilhac, Olivier [Auteur]
CHU Estaing [Clermont-Ferrand]

Journal title :

eJHaem

Pages :

371 - 378

Publisher :

Wiley

Publication date :

2022-02-08

English keyword(s) :

Waldenström's macroglobulinemia
mast cells
tumor biology

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

<div><p>The presence of numerous mast cells (MCs) mixed with tumor cells in the bone marrow (BM) is a hallmark of the diagnosis of Waldenström's macroglobulinemia (WM).</p><p>MCs have been shown to support lymphoplasmacytic ...
Show more ><div><p>The presence of numerous mast cells (MCs) mixed with tumor cells in the bone marrow (BM) is a hallmark of the diagnosis of Waldenström's macroglobulinemia (WM).</p><p>MCs have been shown to support lymphoplasmacytic cell growth, but there is thus far no demonstration of the prognostic impact of BM MC density in WM. We investigated BM MC density by sensitive and specific digital quantification, allowing the analysis of a large area infiltrated by BM tumor cells. A total of 65 WM patients were investigated, including 54 at diagnosis and 11 at relapse. Tryptase and CD20 immunohistochemisty staining was performed on contiguous sections of deparaffinized BM trephine biopsies. After numerization of each section, the BM surface area was manually marked out,</p></div>Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL