Concomitant association of giant cell ...
Document type :
Article dans une revue scientifique: Article original
PMID :
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Title :
Concomitant association of giant cell arteritis and malignancy: a multicenter retrospective case-control study.
Author(s) :
Deshayes, S [Auteur]
Université de Caen Normandie [UNICAEN]
Liozon, Eric [Auteur]
CHU Limoges
Chanson, N [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Sacre, Karim [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Moulinet, T [Auteur]
Blanchard-Delaunay, Claire [Auteur]
Centre Hospitalier Georges Renon [Niort] [CH Georges Renon Niort]
Espitia, Olivier [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Groh, Matthieu [Auteur]
Hôpital Foch [Suresnes]
Versini, M [Auteur]
Institut Arnault Tzanck
Le Gallou, Thomas [Auteur]
Centre Hospitalier Universitaire [Rennes]
Kahn, Jean-Emmannuel [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Grobost, V [Auteur]
Service Médecine Interne - site Gabriel-Montpied [CHU Clermont-Ferrand]
Humbert, S [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Samson, Maxime [Auteur]
CHU Dijon
Mourot Cottet, R [Auteur]
Mazodier, K [Auteur]
Médecine interne et immunologie clinique [Hôpital de la Conception - APHM]
Dartevel, A [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Campagne, J [Auteur]
Dumont, A [Auteur]
Université de Caen Normandie [UNICAEN]
Bienvenu, B [Auteur]
Hôpital Saint-Joseph [Marseille]
Lambert, Marc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center (LIRIC) - U995
Saadoun, David [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Aouba, A. [Auteur]
Université de Caen Normandie [UNICAEN]
Université de Caen Normandie [UNICAEN]
Liozon, Eric [Auteur]
CHU Limoges
Chanson, N [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Sacre, Karim [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Moulinet, T [Auteur]
Blanchard-Delaunay, Claire [Auteur]
Centre Hospitalier Georges Renon [Niort] [CH Georges Renon Niort]
Espitia, Olivier [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Groh, Matthieu [Auteur]
Hôpital Foch [Suresnes]
Versini, M [Auteur]
Institut Arnault Tzanck
Le Gallou, Thomas [Auteur]
Centre Hospitalier Universitaire [Rennes]
Kahn, Jean-Emmannuel [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]
Grobost, V [Auteur]
Service Médecine Interne - site Gabriel-Montpied [CHU Clermont-Ferrand]
Humbert, S [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Samson, Maxime [Auteur]
CHU Dijon
Mourot Cottet, R [Auteur]
Mazodier, K [Auteur]
Médecine interne et immunologie clinique [Hôpital de la Conception - APHM]
Dartevel, A [Auteur]
Centre Hospitalier Universitaire [CHU Grenoble] [CHUGA]
Campagne, J [Auteur]
Dumont, A [Auteur]
Université de Caen Normandie [UNICAEN]
Bienvenu, B [Auteur]
Hôpital Saint-Joseph [Marseille]
Lambert, Marc [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center (LIRIC) - U995
Saadoun, David [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Aouba, A. [Auteur]
Université de Caen Normandie [UNICAEN]
Journal title :
Clinical Rheumatology
Abbreviated title :
Clin. Rheumatol.
Volume number :
38
Pages :
1243–1249
Publication date :
2019-05-01
ISSN :
1434-9949
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
BACKGROUND: Some studies suggest that there is an increased risk of malignancies in giant cell arteritis (GCA). We aimed to describe the clinical characteristics and outcomes of GCA patients with concomitant malignancy and ...
Show more >BACKGROUND: Some studies suggest that there is an increased risk of malignancies in giant cell arteritis (GCA). We aimed to describe the clinical characteristics and outcomes of GCA patients with concomitant malignancy and compare them to a GCA control group. METHODS: Patients with a diagnosis of GCA and malignancy and with a maximal delay of 12 months between both diagnoses were retrospectively included in this study and compared to a control group of age-matched (3:1) patients from a multicenter cohort of GCA patients. RESULTS: Forty-nine observations were collected (median age 76 years). Malignancies comprised 33 (67%) solid neoplasms and 16 (33%) clonal hematologic disorders. No over-representation of a particular type of malignancy was observed. Diagnosis of GCA and malignancy was synchronous in 7 (14%) patients, while malignancy succeeded GCA in 29 (59%) patients. Malignancy was fortuitously diagnosed based on abnormalities observed in laboratory tests in 26 patients, based on imaging in 14 patients, and based on symptoms or clinical examination in the nine remaining patients. Two patients had a concomitant relapse of both conditions. When compared to the control group, patients with concomitant GCA and malignancy were more frequently male (p < 0.001), with an altered general state (p < 0.001), and polymyalgia rheumatica (p < 0.01). CONCLUSIONS: This study does not indicate an over-representation of any particular type of malignancy in GCA patients. Initial follow-up dictated by vasculitis may have led to an early identification of malignancy. Nevertheless, GCA male patients with an altered general state and polymyalgia rheumatica might more frequently show concomitant malignancies.Show less >
Show more >BACKGROUND: Some studies suggest that there is an increased risk of malignancies in giant cell arteritis (GCA). We aimed to describe the clinical characteristics and outcomes of GCA patients with concomitant malignancy and compare them to a GCA control group. METHODS: Patients with a diagnosis of GCA and malignancy and with a maximal delay of 12 months between both diagnoses were retrospectively included in this study and compared to a control group of age-matched (3:1) patients from a multicenter cohort of GCA patients. RESULTS: Forty-nine observations were collected (median age 76 years). Malignancies comprised 33 (67%) solid neoplasms and 16 (33%) clonal hematologic disorders. No over-representation of a particular type of malignancy was observed. Diagnosis of GCA and malignancy was synchronous in 7 (14%) patients, while malignancy succeeded GCA in 29 (59%) patients. Malignancy was fortuitously diagnosed based on abnormalities observed in laboratory tests in 26 patients, based on imaging in 14 patients, and based on symptoms or clinical examination in the nine remaining patients. Two patients had a concomitant relapse of both conditions. When compared to the control group, patients with concomitant GCA and malignancy were more frequently male (p < 0.001), with an altered general state (p < 0.001), and polymyalgia rheumatica (p < 0.01). CONCLUSIONS: This study does not indicate an over-representation of any particular type of malignancy in GCA patients. Initial follow-up dictated by vasculitis may have led to an early identification of malignancy. Nevertheless, GCA male patients with an altered general state and polymyalgia rheumatica might more frequently show concomitant malignancies.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Submission date :
2019-10-22T08:09:15Z
2024-03-22T09:50:56Z
2024-03-22T09:50:56Z