Title :

Pediatric Eosinophilic Esophagitis: Results of the European Retrospective Pediatric Eosinophilic Esophagitis Registry (RetroPEER).

Author(s) :

Hoofien, Assaf [Auteur]
Dias, Jorge A [Auteur]
Malamisura, Monica [Auteur]
Rea, Francesca [Auteur]
Chong, Sonny [Auteur]
Oudshoorn, Johanna [Auteur]
Nijenhuis-Hendriks, Danielle [Auteur]
Otte, Sebastian [Auteur]
Papadopoulou, Alexandra [Auteur]
Romano, Claudio [Auteur]
gottrand, Fréderic [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Miravet, Victor V [Auteur]
Orel, Rok [Auteur]
Oliva, Salvatore [Auteur]
Junquera, Carolina G [Auteur]
Zaleski, Andrzej [Auteur]
Urbonas, Vaidotas [Auteur]
Garcia-Puig, Roger [Auteur]
Gomez, Maria J M [Auteur]
Dominguez-Ortega, Gloria [Auteur]
Auth, Marcus [Auteur]
Kori, Michal [Auteur]
Ben Tov, Amir [Auteur]
Kalach, Nicolas [Auteur]
Velde, Saskia V [Auteur]
Furman, Mark [Auteur]
Miele, Erasmo [Auteur]
Marderfeld, Luba [Auteur]
Roma, Eleftheria [Auteur]
Zevit, Noam [Auteur]

Journal title :

Journal of Pediatric Gastroenterology and Nutrition

Abbreviated title :

J. Pediatr. Gastroenterol. Nutr.

Volume number :

68

Pages :

552-558

Publication date :

2019-04

ISSN :

1536-4801

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: Recommendations for diagnosing and treating eosinophilic esophagitis (EoE) are evolving; however, information on real world clinical practice is lacking. To assess the practices of pediatric gastroenterologists ...
Show more >OBJECTIVE: Recommendations for diagnosing and treating eosinophilic esophagitis (EoE) are evolving; however, information on real world clinical practice is lacking. To assess the practices of pediatric gastroenterologists diagnosing and treating EoE and to identify the triggering allergens in European children. METHODS: Retrospective anonymized data were collected from 26 European pediatric gastroenterology centers in 13 countries. Inclusion criteria were: Patients diagnosis with EoE, completed investigations prescribed by the treating physician, and were on stable medical or dietary interventions. RESULTS: In total, 410 patients diagnosed between December 1999 and June 2016 were analyzed, 76.3% boys. The time from symptoms to diagnosis was 12 ± 33.5 months and age at diagnosis was 8.9 ± 4.75 years. The most frequent indications for endoscopy were: dysphagia (38%), gastroesophageal reflux (31.2%), bolus impaction (24.4%), and failure to thrive (10.5%). Approximately 70.3% had failed proton pump inhibitor treatment. The foods found to be causative of EoE by elimination and rechallenge were milk (42%), egg (21.5%), wheat/gluten (10.9%), and peanut (9.9%). Elimination diets were used exclusively in 154 of 410 (37.5%), topical steroids without elimination diets in 52 of 410 (12.6%), both diet and steroids in 183 of 410 (44.6%), systemic steroids in 22 of 410 (5.3%), and esophageal dilation in 7 of 410 (1.7%). Patient refusal, shortage of endoscopy time, and reluctance to perform multiple endoscopies per patient were noted as factors justifying deviation from guidelines. CONCLUSIONS: In this "real world" pediatric European cohort, milk and egg were the most common allergens triggering EoE. Although high-dose proton pump inhibitor trials have increased, attempted PPI treatment is not universal.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2019-10-22T08:09:21Z
2024-01-24T18:02:20Z