Update of the tolerable upper intake level ...
Type de document :
Article dans une revue scientifique: Article original
DOI :
PMID :
URL permanente :
Titre :
Update of the tolerable upper intake level for vitamin D for infants
Auteur(s) :
Turck, Dominique [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Bresson, Jean-Louis [Auteur]
Burlingame, Barbara [Auteur]
Dean, Tara [Auteur]
Fairweather-Tait, Susan [Auteur]
Heinonen, Marina [Auteur]
Hirsch-Ernst, Karen-Ildico [Auteur]
Mangelsdorf, Inge [Auteur]
Mcardle, Harry J. [Auteur]
Naska, Androniki [Auteur]
Nowicka, Grazyna [Auteur]
Pentieva, Kristina [Auteur]
Sanz, Yolanda [Auteur]
Siani, Alfonso [Auteur]
Sjodin, Anders [Auteur]
Stern, Martin [Auteur]
Tome, Daniel [Auteur]
Van Loveren, Henk [Auteur]
Vinceti, Marco [Auteur]
Willatts, Peter [Auteur]
Fewtrell, Mary [Auteur]
Lamberg-Allardt, Christel [Auteur]
Przyrembel, Hildegard [Auteur]
Arcella, Davide [Auteur]
Dumas, Celine [Auteur]
Fabiani, Lucia [Auteur]
Martino, Laura [Auteur]
Tomcikova, Daniela [Auteur]
Neuhauser-Berthold, Monika [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Bresson, Jean-Louis [Auteur]
Burlingame, Barbara [Auteur]
Dean, Tara [Auteur]
Fairweather-Tait, Susan [Auteur]
Heinonen, Marina [Auteur]
Hirsch-Ernst, Karen-Ildico [Auteur]
Mangelsdorf, Inge [Auteur]
Mcardle, Harry J. [Auteur]
Naska, Androniki [Auteur]
Nowicka, Grazyna [Auteur]
Pentieva, Kristina [Auteur]
Sanz, Yolanda [Auteur]
Siani, Alfonso [Auteur]
Sjodin, Anders [Auteur]
Stern, Martin [Auteur]
Tome, Daniel [Auteur]
Van Loveren, Henk [Auteur]
Vinceti, Marco [Auteur]
Willatts, Peter [Auteur]
Fewtrell, Mary [Auteur]
Lamberg-Allardt, Christel [Auteur]
Przyrembel, Hildegard [Auteur]
Arcella, Davide [Auteur]
Dumas, Celine [Auteur]
Fabiani, Lucia [Auteur]
Martino, Laura [Auteur]
Tomcikova, Daniela [Auteur]
Neuhauser-Berthold, Monika [Auteur]
Titre de la revue :
EFSA Journal
Nom court de la revue :
EFSA J.
Numéro :
16
Pagination :
e05365
Date de publication :
2018-08
ISSN :
1831-4732
Mot(s)-clé(s) en anglais :
adverse health outcomes
25(OH)D
UL
intake
infants
vitamin D
25(OH)D
UL
intake
infants
vitamin D
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to revise the tolerable upper intake level (UL) for vitamin D for infants (≤ 1 year) set in 2012. ...
Lire la suite >Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to revise the tolerable upper intake level (UL) for vitamin D for infants (≤ 1 year) set in 2012. From its literature review, the Panel concluded that the available evidence on daily vitamin D intake and the risk of adverse health outcomes (hypercalciuria, hypercalcaemia, nephrocalcinosis and abnormal growth patterns) cannot be used alone for deriving the UL for infants. The Panel conducted a meta-regression analysis of collected data, to derive a dose–response relationship between daily supplemental intake of vitamin D and mean achieved serum 25(OH)D concentrations. Considering that a serum 25(OH)D concentration of 200 nmol/L or below is unlikely to pose a risk of adverse health outcomes in infants, the Panel estimated the percentage of infants reaching a concentration above this value at different intakes of vitamin D. Based on the overall evidence, the Panel kept the UL of 25 μg/day for infants aged up to 6 months and set a UL of 35 μg/day for infants 6–12 months. The Panel was also asked to advise on the safety of the consumption of infant formulae with an increased maximum vitamin D content of 3 μg/100 kcal (Commission Delegated Regulation (EU) 2016/127 repealing Directive 2006/141/EC in 2020). For infants aged up to 4 months, the intake assessment showed that the use of infant formulae containing vitamin D at 3 μg/100 kcal may lead some infants to receive an intake above the UL of 25 μg/day from formulae alone without considering vitamin D supplemental intake. For infants aged 4–12 months, the 95th percentile of vitamin D intake (high consumers) estimated from formulae and foods fortified or not with vitamin D does not exceed the ULs, without considering vitamin D supplemental intake.Lire moins >
Lire la suite >Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to revise the tolerable upper intake level (UL) for vitamin D for infants (≤ 1 year) set in 2012. From its literature review, the Panel concluded that the available evidence on daily vitamin D intake and the risk of adverse health outcomes (hypercalciuria, hypercalcaemia, nephrocalcinosis and abnormal growth patterns) cannot be used alone for deriving the UL for infants. The Panel conducted a meta-regression analysis of collected data, to derive a dose–response relationship between daily supplemental intake of vitamin D and mean achieved serum 25(OH)D concentrations. Considering that a serum 25(OH)D concentration of 200 nmol/L or below is unlikely to pose a risk of adverse health outcomes in infants, the Panel estimated the percentage of infants reaching a concentration above this value at different intakes of vitamin D. Based on the overall evidence, the Panel kept the UL of 25 μg/day for infants aged up to 6 months and set a UL of 35 μg/day for infants 6–12 months. The Panel was also asked to advise on the safety of the consumption of infant formulae with an increased maximum vitamin D content of 3 μg/100 kcal (Commission Delegated Regulation (EU) 2016/127 repealing Directive 2006/141/EC in 2020). For infants aged up to 4 months, the intake assessment showed that the use of infant formulae containing vitamin D at 3 μg/100 kcal may lead some infants to receive an intake above the UL of 25 μg/day from formulae alone without considering vitamin D supplemental intake. For infants aged 4–12 months, the 95th percentile of vitamin D intake (high consumers) estimated from formulae and foods fortified or not with vitamin D does not exceed the ULs, without considering vitamin D supplemental intake.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Date de dépôt :
2019-10-22T08:09:56Z
2024-01-15T12:37:57Z
2024-01-15T12:37:57Z
Fichiers
- EFSA Journal - 2018 - - Update of the tolerable upper intake level for vitamin D for infants.pdf
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