An innovative and efficient method to ...
Type de document :
Article dans une revue scientifique: Article original
URL permanente :
Titre :
An innovative and efficient method to synthesize meloxicam in one-step procedure with respect to the green chemistry
Auteur(s) :
Dufrenoy, Pierrick [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Ghinet, Alina [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Hechelski, Marie [Auteur]
Laboratoire de Génie Civil et Géo-Environnement (LGCgE) - ULR 4515 [LGCgE]
Daich, Adam [Auteur]
Université Le Havre Normandie [ULH]
Waterlot, Christophe [Auteur]
Laboratoire de Génie Civil et Géo-Environnement (LGCgE) - ULR 4515 [LGCgE]
Lille Inflammation Research International Center - U 995 [LIRIC]
Ghinet, Alina [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Hechelski, Marie [Auteur]
Laboratoire de Génie Civil et Géo-Environnement (LGCgE) - ULR 4515 [LGCgE]
Daich, Adam [Auteur]
Université Le Havre Normandie [ULH]
Waterlot, Christophe [Auteur]
Laboratoire de Génie Civil et Géo-Environnement (LGCgE) - ULR 4515 [LGCgE]
Titre de la revue :
Journal of the Iranian Chemical Society
Nom court de la revue :
J. Iran Chem. Soc.
Numéro :
16
Pagination :
501-509
Date de publication :
2019-03-13
ISSN :
1735-207X
Mot(s)-clé(s) en anglais :
Metrics
Meloxicam
Green chemistry
Heterogeneous catalyst
Montmorillonite K10
Meloxicam
Green chemistry
Heterogeneous catalyst
Montmorillonite K10
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
An improved procedure for the synthesis of meloxicam drug (methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazol-2-amine-3-carboxylate 1,1-dioxide) was described in one-step using mainly impregnated montmorillonite K10 (MK10) with ...
Lire la suite >An improved procedure for the synthesis of meloxicam drug (methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazol-2-amine-3-carboxylate 1,1-dioxide) was described in one-step using mainly impregnated montmorillonite K10 (MK10) with ZnCl2 as a heterogeneous catalyst. This innovative method was compared to the last described procedure employed in the manufacture of this anti-inflammatory drug by means of some metrics used in a first step of the evaluation process of the environmental impact of a chemical transformation. Apart from the yield, which was 90%, atom economy, waste, environmental factor, reaction mass efficiency and stoichiometric factor were calculated as 91.6%, 8.4%, 0, 8.1% and 1%, respectively. Interpretation of these metrics was given and highlighted the fact that the strategy used in the current study may be considered as an environmental-friendly and sustainable method that fits well in the green chemistry concepts.Lire moins >
Lire la suite >An improved procedure for the synthesis of meloxicam drug (methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazol-2-amine-3-carboxylate 1,1-dioxide) was described in one-step using mainly impregnated montmorillonite K10 (MK10) with ZnCl2 as a heterogeneous catalyst. This innovative method was compared to the last described procedure employed in the manufacture of this anti-inflammatory drug by means of some metrics used in a first step of the evaluation process of the environmental impact of a chemical transformation. Apart from the yield, which was 90%, atom economy, waste, environmental factor, reaction mass efficiency and stoichiometric factor were calculated as 91.6%, 8.4%, 0, 8.1% and 1%, respectively. Interpretation of these metrics was given and highlighted the fact that the strategy used in the current study may be considered as an environmental-friendly and sustainable method that fits well in the green chemistry concepts.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Équipe(s) de recherche :
Therapeutic innovation targetting inflammation
Date de dépôt :
2019-10-22T08:16:41Z
2023-12-08T10:23:19Z
2023-12-08T10:23:19Z